Clinical trials: Prostaglandin E2
Vitreous Inflammation
NSAIDs and PGE2 Levels in Vitrectomy Patients
The purpose of this study is to assess vitreous concentrations of nonsteroidal antiinflammatory drugs (NSAIDs) and prostaglandin E2 in patients treated with NSAIDs before vitrectomy.
- Trial name
- NCT02361645
- Testing
- Ketorolac 0.5% eyedrops, Indomethacin 0.5% eyedrops, Bromfenac 0.09% eyedrops
- Volunteers
- 70 people
- Sponsor
- Università degli Studi di Brescia
Apical Periodontitis, Inflammatory Markers
The Efficacy of Two Different Irrigation Methods on PGE2, NO and IL-6 Levels
Today, debates about the effectiveness of Passive Ultrasonic Irrigation (PUI) and Sonically Activated Irrigation (SAI) techniques used to increase the success of endodontic treatment in chronic apical periodontitis (AP) are still…
- Trial name
- NCT06629545
- Testing
- irrigation activation with PUI, irrigation with sonic activation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Headache, Migraine
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model
The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.
- Trial name
- NCT00957983
- Testing
- BGC20-1531
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Labor Pain
Prostin and Propess in Induction of Labor
The purpose of the study was to compare the safety and efficacy of two agents used in induction of labor Propess (Controlled release dinoprostone, PGE2, pessary) and Prostin E2 (Dinoprostone vaginal Tablet).
- Trial name
- NCT01635439
- Testing
- Propess, Prostin E2
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Myomectomy
Preoperative Vaginal Dinoprostone Prior to Abdominal Myomectomy
The aim of the study is to compare the effectiveness of vaginal dinoprostone 3 mg versus placebo before myomectomy to decrease blood loss during and after the operation.
- Trial name
- NCT04080375
- Testing
- Dinoprostone 3 mg
- Volunteers
- 100 people
- Sponsor
- Cairo University
Induction of Labor Affected Fetus / Newborn, Prostaglandins Causing Adverse Effects in Therapeutic Use
Induction of Labor in Term Pregnancies With Unfavourable Cervix
This is a prospective randomized trial comparing two prostaglandin E2 (dinoprostone) agents used for labor induction in pregnant women with term pregnancies and unfavorable cervix.
- Trial name
- RAND (NCT04280874)
- Testing
- Dinoprostone 0.5 MG, Dinoprostone 2 MG/2.5 ML Vaginal Gel/Jelly
- Where
- Croatia
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Merkur
Laminectomy, Postperative Pain Management
Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy
Laminectomy is a routine procedure for patients with lumbar spinal stenosis, offering significant benefits such as reduced low back pain, alleviation of radiculopathy, and improved motor strength 1 23.
- Conditions
- Laminectomy, Postperative Pain Management, Prostaglandin E2, Lumbal Disc Herniation
- Trial name
- NCT07429708
- Testing
- Bilateral ESPB: Ropivacaine 0.375% + Dexamethasone 5mg, Bilateral ESPB: Ropivacaine 0.375%
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Udayana University
Delivery Uterine, Birth; Induced
Contribution of Ultrasonography in the Evaluation of Cervical Induction-delivery Time
Study of the contribution of ultrasound measurements of the uterine cervix related to the calculation of Bishop score. Evaluation of the period between cervical induction and delivery.
- Trial name
- ECOLDIA (NCT02570620)
- Testing
- Ultrasonography of the cervix
- Where
- 3 sites in France
- Volunteers
- 342 people
- Sponsor
- University Hospital, Tours
IUD Pain
Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women Delivered Only by Cesarean Delivery
To compare the effect of vaginal dinoprostone versus vaginal misoprostol administered before the copper intrauterine device(IUD) insertion in reducing IUD insertion pain and the difficulty in inserting the IUD in women delivered…
- Trial name
- NCT04080349
- Testing
- Dinoprostone 3 mg, Misoprostol 200Mcg Tab
- Volunteers
- 300 people
- Sponsor
- Cairo University
Induction of Labor
Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter
One of every four births in the Western world is induced, usually due to the risk of maternal and fetal morbidity. There are several methods of labor induction, pharmacological and mechanical.
- Trial name
- NCT06803992
- Testing
- Dinoprostone vaginal insert, Dinoprostone gel and Foley catheter balloon
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- HaEmek Medical Center, Israel
Cervical Ripening, Labor, Induced
Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor
The purpose of this study is to determine whether the misoprostol vaginal insert (50 mcg and 100 mcg) can safely and effectively speed time to vaginal delivery compared to Cervidil (R) in women who need to have cervical ripneing…
- Trial name
- NCT00308711
- Testing
- Misoprostol vaginal insert 100 mcg, Misoprostol vaginal insert 50 mcg, Dinoprostone vaginal insert (Cervidil)
- Where
- 52 sites in United States, Canada
- Volunteers
- 1,308 people
- Sponsor
- Ferring Pharmaceuticals
Pregnancy
Effects of Vaginal Lactoferrin Administration Prior to Genetic Amniocentesis on Inflammatory Mediators
The aim of the study is to evaluate the effect of vaginal lactoferrin administration on amniotic fluid PGE2 level and MMP-TIMP system in women undergoing genetic amniocentesis.
- Trial name
- NCT02695563
- Testing
- Lactoferrin
- Where
- Italy
- Volunteers
- 111 people
- Sponsor
- Università degli Studi di Ferrara
PROM (Premature Rupture Of Foetal Membrane)
Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes
The objective is to demonstrate the superiority of the strategy of labor induction by Cook® cervical ripening balloon between recommended strategy by dinoprostone (propess®) on the reduction of the time between cervical ripening…
- Trial name
- RUBAPRO (NCT03310333)
- Testing
- Propess® (dinoprostone), cook cervical pipening balloon
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cataract
Topical 0.1% Bromfenac Sodium and Prostaglandin E2 Inhibition in Cataract Surgery
Since a new generation of femtosecond lasers became available for cataract surgery in 2009, the use of this image-guided system has provided several benefits, including a reduction in phacoemulsification energy by…
- Trial name
- NCT02681679
- Testing
- 0.1% bromfenac ophthalmic solution, femtosecond laser cataract surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Intrauterine Device
Vaginal Dinoprostone Administration Prior to a T380A Intrauterine Device Insertion in Nulliparous Women.
To investigate whether vaginal dinoprostone administered before intrauterine device (IUD) insertion reduces failed insertions, insertion-related complications and pain in nulliparous women.
- Trial name
- NCT03686085
- Testing
- Dinoprostone 3 mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Failed Induction of Labor
Foley Catheter Versus Dinoprostone Vaginal Insert for Induction of Labor in Parous Women at Term: A Randomized Trial
The purpose of this study is to assess the effectiveness and safety of transcervical foley catheter as compared to dinoprostone vaginal insertion for preinduction cervical ripening and labor induction in term parous women with…
- Trial name
- NCT01596296
- Testing
- Transcervical foley catheter, Dinoprostone 10mg
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Menstrual Migraine
CGRP, Estrogen, Cortisol, VIP, α-Amylase, PGE2, PGI2 and ß-Endorphin Levels in Menstrual Migraine Before and After Treximet
The purpose of this study is to (1) evaluate pain-free efficacy of Treximet™ following treatment of menstrual migraine, (2) investigate levels of Calcitonin gene-related peptide (CGRP), estrogen, cortisol, vasoactive intestinal…
- Trial name
- NCT01329562
- Testing
- Treximet
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Cady, Roger, M.D.
Percutaneous Nephrolithotomy (PCNL), Postoperative Pain
The Effect of NSAID Steroid Therapy for PGE2 Level and Analgesia After Percutaneous Nephrolithotomy Surgery
The goal of this clinical trial is to learn if combination of NSAID-steroid can decrease the PGE2 level and postoperative pain after percutaneous nephrolithotomy surgery.
- Trial name
- BUPARDEX (NCT06604598)
- Testing
- IBU-PCT-DEX
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Jenderal Soedirman
Failed Labour
Comparison of Pre-Induction Cervical Ripening
This study is designed to assess the effectiveness of a combination method of induction of labor using a urinary balloon catheter and prostaglandin gel.
- Trial name
- NCT01390233
- Testing
- Prepidil Gel, Urinary Balloon Catheter, Combined Urinary Catheter & Prepidil Gel
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of South Carolina
Refractory Metastatic Colorectal Cancer, Solid Tumor
Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI Cancers
This Phase Ib/IIa study comprises a Main Study and a Study Extension. The Main Study has been designed according to a 3+3 Dose Escalation/dose Expansion design in refractory pMMR-MSS mCRC patients.
- Conditions
- Refractory Metastatic Colorectal Cancer, Solid Tumor, Metastatic Microsatellite-stable Colorectal Cancer, Mismatch Repair Protein Proficient
- Trial name
- NCT05205330
- Testing
- CR6086, AGEN2034
- Where
- 3 sites in Italy
- Volunteers
- 107 people
- Sponsor
- Rottapharm Biotech