Clinical trials: Prostaglandins
Premature Rupture of Fetal Membranes
Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop
The purpose of the study is to compare between oxytocin to prostaglandin (PGE2), regarding time from induction of labor (IOL) to delivery among primiparas at term with prelabor rupture of membrane (PROM) and an unfavorable cervix.
- Trial name
- NCT02801227
- Testing
- Oxytocin, Prostaglandin E2
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Healthy
To Evaluate Safety, Tolerability and Pharmacokinetics of GRC 27864 in Healthy Subjects and Elderly Healthy Subjects
This is a multiple Ascending dose (MAD) study with GRC 27864 in Healthy and Elderly Subjects.
- Trial name
- NCT02361034
- Testing
- GRC 27864
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Glenmark Pharmaceuticals S.A.
Induction of Labor
Stepwise Labor Induction Following Failure of Prostaglandin Vaginal Insert for Labor Induction
Induction of labor is one of the most common obstetrical medical procedures performed today. Iatrogenic stimulation of uterine contractions prior to the onset of spontaneous labor is undertaken for various maternal and fetal…
- Trial name
- NCT02684305
- Testing
- Administration of Propess, balloon, Intravenous oxytocin infusion
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Emphysema
Prostaglandin Inhibition for Emphysema
The Prostaglandin Inhibition for Emphysema (PIE) study will determine if a currently available therapy, ibuprofen 600 mg three times daily, can block PGE production in the lower respiratory tract and if this results in…
- Trial name
- PIE (NCT02006576)
- Testing
- 600 mg ibuprofen three times daily for 48 weeks
- Where
- 5 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Ischemic Reperfusion Injury
Ischemia Reperfusion: Prostaglandins and Antioxidants
The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury.
- Trial name
- NCT01666587
- Testing
- Antioxidant, Prostaglandin inhibitor (Ibuprophen)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Essex
Schizophrenia, Cannabis Abuse
Niacin Flushing as Marker of Cannabis Effects on Arachidonic Acid Pathways in Schizophrenia
Increasing evidence suggests modulating effects of cannabinoids on time of onset, severity, and outcome of schizophrenia. Efforts to discover the underlying pathomechanism have led to the assumption of gene x environment…
- Trial name
- NCT00376233
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Jena
Type 2 Diabetes Mellitus
A Study to Evaluate the Effects of ER Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites (0524A-079)(COMPLETED)
The purpose of this study is to evaluate the potential effects of ER niacin/laropiprant, ER niacin, laropiprant, and placebo over the course of seven days on urinary levels of a specific metabolite (which is a marker of in vivo…
- Trial name
- NCT00618995
- Testing
- Comparator: ER niacin (+) laropiprant, Comparator: ER niacin, Comparator: laropiprant
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Vitiligo
Prostaglandin F2-alpha (PGF2α) in Vitiligo
study the cutaneous expression of PGF2α in vitiligo patients and compare it with normal control subjects.
- Trial name
- NCT03755830
- Testing
- Skin biopsy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Open Angle Glaucoma
Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution
This is a double-masked, placebo-controlled study which will determine the action of NCX 470 ophthalmic solution, 0.1% on aqueous humor dynamic parameters in healthy volunteers or subjects with OHT.
- Trial name
- Whistler (NCT05938699)
- Testing
- NCX 470
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nicox Ophthalmics, Inc.
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Fetus or Newborn or Maternal; Effects of Induction of Labor
Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite Prostaglandin
Premature rupture of membranes (PROM) is a common occurrence that occurs in the incidence of 8-10% of births. Since the duration until delivery is important in avoiding the risk of complications, several studies have been…
- Trial name
- NCT02720978
- Testing
- Intravenous oxytocin, vaginal prostaglandin
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Myocardial Infarction, Arthritis
Mechanisms of Action of Acetaminophen
This research study investigates whether the ability of aspirin to reduce the risk of heart attacks may be diminished by the administration of acetaminophen.
- Trial name
- NCT00646906
- Testing
- Aspirin First, Aspirin Last, Acetaminophen 1000 mg/d
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hypertrichosis
Eyelash Growth From Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes
Objective: To determine if Lumigan (bimatoprost) causes increased lash length when used in gel suspension applied to the base of the eyelashes.
- Trial name
- NCT00773136
- Testing
- Bimatoprost Suspension
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Miami
Inflammatory Disorder of the Cardiovascular System
Polyphenols Supplementation on Prostaglandin E2 in Women - Randomized Clinical Trial
The aim of this study was to evaluate the effect of polyphenol supplementation on plasma levels of prostaglandin E2 in women during the reproductive period.
- Trial name
- NCT02567617
- Testing
- Polyphenols
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Healthy
GRC 27864 First in Man, Single Ascending Dose Study in Healthy Volunteers
A Single Dose Study of GRC 27864 in Healthy Volunteers.
- Trial name
- NCT02179645
- Testing
- GRC 27864, Celecoxib
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Periodontitis, Type 2 Diabetes
Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment
Diabetes and periodontal disease are the most common chronic multifactorial and inflammatory diseases in humans, and there is a bidirectional relationship between type 2 diabetes and periodontitis.
- Trial name
- NCT05454059
- Testing
- Non-surgical periodontal treatment, ELISA Test, Periodontal Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Early Amniotomy, Unfavorable Cervix
Early Amniotomy After Vaginal Prostaglandin E2 for Induction of Labor at Term: a Randomized Clinical Trial
This study evaluates the effectiveness and safety of early amniotomy after vaginal prostaglandin E2 for induction of labor at term.
- Trial name
- PGE2 (NCT02856724)
- Testing
- PGE2
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Missed Abortion, Periodontitis
Periodontal Pathogens and Inflammatory Biomarkers in Missed Abortion
This observational case-control study will investigate whether periodontal infection and inflammation are associated with missed abortion in pregnancies without detected major fetal chromosomal abnormalities.
- Trial name
- NCT07864220
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Metabolism of Prostaglandin D2
Pathways of Eicosanoid Metabolism
Prostaglandins are important signaling compounds formed from arachidonic acid. The enzymes that form prostaglandins, cyclooxygenase-1 and -2 are the targets of non-steroidal anti-inflammatory drugs (NSAIDs).
- Trial name
- NCT04464070
- Testing
- niacin, aspirin, PGD2
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Headache, Migraine
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model
The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.
- Trial name
- NCT00957983
- Testing
- BGC20-1531
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center