Clinical trials: Prostate Biopsy
Prostate Cancer
Ga-68 PSMA PET/CT vs mpMRI in Cognitive Prostate Biopsy
Prostate cancer is the most common malignancy among elderly men. With the routine use of prostate-specific antigen (PSA) testing since the 1980s, the incidence of prostate cancer has significantly increased.
- Trial name
- PSMA-MRI BX (NCT07533344)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Prostate Cancer, Prostate Adenocarcinoma
The Efficacy of Mapping for Cognitive Prostate Biopsy
Today, many centers still perform Magnetic Resonance Imaging (MRI) cognitive prostate biopsy. The efficacy of detecting clinically significant prostate cancer, which is thought to be due to the experience of the urologist who…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostatic Neoplasms, Prostate Disease
- Trial name
- MAPROSTATE (NCT05902637)
- Testing
- Performing cognitive prostate biopsy with a radiologist's guidance with map, Performing cognitive prostate biopsy without a radiologist's guidance with map
- Where
- Turkey (Türkiye)
- Volunteers
- 175 people
- Sponsor
- Marmara University
Complication
A Test of the Comparison Between Trans-rectal and Trans-perineal Biopsy of Prostate
The purpose of this randomized controlled trial (RCT) is to compare the two ways (tras-rectal and trans-perineal) to perform prostate biopsy from the rate of Positive detection, complications, pain level, operation time and costs…
- Trial name
- RCT (NCT01849835)
- Testing
- trans-rectal to perform the prostate biopsy, trans-perineal to perform the prostate biopsy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai 10th People's Hospital
Prostate Cancer
Infective Complications in TP Biopsy Without Antibiotic Prophylaxis
This study is a prospective cohort study to delineate the infective outcomes and incidence after transperineal prostate biopsy with no antibiotic prophylaxis, compared to the existing data on outcomes on patients receiving…
- Trial name
- NCT06359964
- Testing
- Transperineal Biopsy without antibiotics prophylaxis, Transperineal Biopsy with antibiotics prophylaxis
- Where
- Hong Kong
- Volunteers
- 1,753 people
- Sponsor
- Chinese University of Hong Kong
Conditions Influencing Health Status, Healthy
Comparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome
This randomized pilot phase I trial studies the best way, either expressed prostatic secretion (EPS) or post massage urine (PMU) biomarkers, of predicting biopsy results in patients undergoing prostate biopsy.
- Conditions
- Conditions Influencing Health Status, Healthy, Prostate Cancer
- Trial name
- NCT01441687
- Testing
- laboratory biomarker analysis, transrectal prostate biopsy
- Where
- 5 sites in United States
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Magnetic Resonance Imaging to Locate and Characterize Prostate Cancer
This study will examine the usefulness of an imaging procedure called dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for localizing and characterizing prostate cancer.
- Trial name
- NCT00082147
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer, Adenocarcinoma
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
To evaluate the role of biparametric MRI and image-fusion targeted biopsies for the detection of prostate cancer. To determine whether biparametric MRI (bpMRI) could be recommended as an alternative to multiparametric MRI (mpMRI)…
- Conditions
- Prostate Cancer, Adenocarcinoma, Prostatic Neoplasms, Prostatic Diseases
- Trial name
- IP7-PACIFIC (NCT05574647)
- Testing
- bpMRI, Image-Fusion targeted and systematic Biopsy
- Where
- 15 sites in United Kingdom
- Volunteers
- 3,600 people
- Sponsor
- Imperial College London
Prostate Cancer, Elevated PSA
A Prospective, Randomized Trial Comparing Office-based MR-guided Prostate Biopsy Approaches
This randomized trial will compare the safety and efficacy of TPM versus TRUS biopsies performed in the outpatient setting. Primary endpoints will be pain as well as detection of clinically significant disease (defined as Gleason…
- Trial name
- NCT03632655
- Testing
- prostate biopsy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Weill Medical College of Cornell University
Prostate Cancer, Magnetic Resonance Imaging
Detection of Clinically Significant Prostate Cancer Using Transperineal Targeted Biopsy Compared to Standard Transrectal Biopsy
Prostate biopsies are currently the gold standard for the diagnosis of prostate cancer. Many biopsies, however, are unnecessary or cannot detect significant prostate cancer (PCa).
- Conditions
- Prostate Cancer, Magnetic Resonance Imaging, Target Lesion, Fusion Biopsy
- Trial name
- NCT03044197
- Testing
- MRI/ultrasound transperineal prostate biopsy, transrectal ultrasound-guided prostate biopsy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Anesthesia
Mixture Nitrous Oxide - Oxygen 50-50% in Transrectal Prostate Biopsy Guided by Ultrasound
Introduction: Transrectal ultrasound-guided prostate biopsy (TUPB) is the gold standard diagnostic tool for prostate cancer and, though may be well tolerated for some patients, about 65 to 90% of then still complain of…
- Trial name
- NCT02899182
- Testing
- Nitrous Oxide NO, O2
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Suspicion of Prostate Cancer With a Positive Multiparametric Magnetic Resonance of the Prostate
Optimizing the Number of Systematic COres During a MRI Target Biopsy
This is a multicentre, paired-cohort, prospective, controlled study. The patient with a suspicion of PCa and a concomitant positive mpMRI (defined as presence of one lesion PI-RADS ≥ 3) will receive a MRI-TBx (4 target cores).
- Trial name
- NCT04183699
- Testing
- Prostate biopsy
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
A Study of Vismodegib in Men With Metastatic CRPC With Accessible Metastatic Lesions for Tumor Biopsy
This is a single-arm pharmacodynamic study with mandatory metastatic tumor biopsies in men with castration-resistant prostate cancer.
- Trial name
- NCT02115828
- Testing
- Vismodegib
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer, Clinically Significant Prostate Cancer
Transperineal Versus Transrectal Cognitive Fusion Prostate Biopsy
This prospective randomized controlled trial aims to compare transperineal and transrectal cognitive fusion prostate biopsy techniques in patients with suspicious prostate lesions detected by multiparametric magnetic resonance…
- Conditions
- Prostate Cancer, Clinically Significant Prostate Cancer, Cognitive Fusion
- Trial name
- PROCOG (NCT07710807)
- Testing
- Transrectal Cognitive Fusion Prostate Biopsy, Transperineal Cognitive Fusion Prostate Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ankara Etlik City Hospital
Prostate Disease
ConfirmMDx Assay in Multiparametric MRI (mpMRI) PIRADS Scored Lesions After a Negative MR/US Fusion Biopsy
The purpose of this study is to see if the ConfirmMDx assay is useful in finding prostate cancer in patients who are at increased risk for prostate cancer based on elevated PSA and prostate lesion identified on mpMRI.
- Trial name
- NCT03597386
- Where
- United States
- Sponsor
- University of Rochester
Bacterial Infection
Incidence of Antibiotic Resistant E.Coli in Patients Undergoing Repeat Prostate Biopsy
The purpose of this study is to discover how often certain bacteria are found in the rectum at the time of a prostate needle biopsy to diagnose prostate cancer.
- Trial name
- NCT00915213
- Where
- 3 sites in United States
- Volunteers
- 136 people
- Sponsor
- University of California, Irvine
Prostate Cancer
Neoadjuvant Chemohormonal Therapy Followed by Salvage Surgery for High Risk PSA
The aim of this study is to test whether adding chemotherapy/cabazitaxel and hormonal/androgen deprivation therapy before surgical removal of your prostate would improve the outcome of salvage surgery for locally recurrent…
- Trial name
- NCT01531205
- Testing
- Androgen Ablation, Cabazitaxel, Salvage Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Prostate Cancer
MRI-guided Bone Marrow Biopsies of Prostate Cancer Patients
The purpose of this study is to target lesions of the prostate in the bone and to biopsy these lesions using MRI to identify the areas.
- Trial name
- NCT00165386
- Testing
- Magnetic Resonance Imaging, Bone Marrow Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Prostatic Neoplasms
Analysis of Cell-free DNA (cfDNA) in Men With Elevated PSA Levels
This is a multi-centre prospective study in which blood samples will be taken from 1500 male patients aged between 21-80 scheduled for prostate biopsy.
- Trial name
- NCT02771769
- Testing
- blood draw
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chronix Biomedical Corporation
Prostate Cancer
Transperineal Versus Transrectal Prostate Biopsy
Background: Prostate biopsies are essential to diagnose prostate cancer (PCa). Transrectal prostate biopsies (TR-PB) are commonly performed, however disadvantages include the requirement of antibiotic prophylaxis (AP) and higher…
- Trial name
- NCT06027203
- Testing
- prostate biopsy
- Where
- Netherlands
- Volunteers
- 923 people
- Sponsor
- Maastricht University Medical Center
Prostate Cancer, Prostatic Neoplasms
Infectious Outcomes of Povidone-iodine Rectal Cleansing Plus Formalin Disinfection of Needle During Prostate Biopsy
The main purpose of this study is to compare the infectious outcomes of intrarectal povidone-iodine cleansing plus formalin disinfection of needle tip during transrectal ultrasound guided prostate biopsy.
- Conditions
- Prostate Cancer, Prostatic Neoplasms, Prostate Biopsy, Prostatitis
- Trial name
- NCT03879486
- Testing
- Intrarectal povidone-iodine cleansing plus formalin disinfection of needle tip during transrectal ultrasound guided prostate biopsy
- Where
- Brazil
- Volunteers
- 1,257 people
- Sponsor
- Hospital de Transplante Doutor Euryclides de Jesus Zerbini