Clinical trials: Prostate Cancer (Post Prostatectomy)
Prostate Cancer, Biochemical Relapse Fo Malignant Neoplasm of Prostate
PSMA Guided Approach for bIoCHEmical Relapse After Prostatectomy-PSICHE
This observational study was designed to evaluate progression free survival after PSMA-PET/CT based salvage approach for patients affected by biochemical relapse after radical prostatectomy.
- Conditions
- Prostate Cancer, Biochemical Relapse Fo Malignant Neoplasm of Prostate, Prostate Adenocarcinoma, Prostate Cancer Recurrent
- Trial name
- PSICHE (NCT05022914)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Androgen Axis Suppression, Prostatectomy
PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.
1. Personalize treatment for prostate cancer based on how aggressive the disease is and 2. Learn if apalutamide-based treatment can help to reduce fatigue and other side effects of treatment in participants who are being treated…
- Conditions
- Androgen Axis Suppression, Prostatectomy, Prostate Cancer
- Trial name
- NCT06274047
- Testing
- Apalutamide, Androgen Deprivation Therapy
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer (Adenocarcinoma), Prostate CA
FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer
The goal of this clinical trial is to learn if the vaccine FK-PC101 works to delay or prevent the return of prostate cancer in men who have had surgery to remove their prostate cancer.
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate CA, Prostate Cancers, Prostate Cancer (Post Prostatectomy)
- Trial name
- NCT06636682
- Testing
- FK-PC101, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Cellvax Therapeutics Inc
Prostate Cancer, Urinary Incontinence
Augmented BLAdder NecK rEconstruction Trial for Improved Urinary Function After Radical Prostatectomy
The investigators are conducting a prospective, randomized trial to investigate whether patients randomized to receive an augmented bladder neck reconstruction (aBNR) at the time of robotic-assisted laparoscopic prostatectomy…
- Conditions
- Prostate Cancer, Urinary Incontinence, Surgery
- Trial name
- BLANKET (NCT04305379)
- Testing
- Augmented Bladder Neck Reconstruction, Standard Bladder Neck Reconstruction
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Johns Hopkins University
Prostate Cancer
Pneumatic Compression and Post-induction Hypotension
The purpose of this study is to evaluate the effect of pneumatic compression on post-induction hypotension in elderly patients undergoing robot assisted laparoscopic prostatectomy.
- Trial name
- NCT05343689
- Testing
- Pneumatic compression
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Prostate Cancer
A Salvage Trial of AR Inhibition With ADT and Apalutamide With Radiation Therapy Followed by Docetaxel in Men With PSA Recurrent Prostate Cancer After Radical Prostatectomy (STARTAR)
The purpose of this study is to describe the rate of 3-year progression free survival in men with recurrent PSA-only disease after prostatectomy, who receive combined apalutamide (ARN-509) and standard ADT with salvage radiation…
- Trial name
- NCT03311555
- Testing
- Apalutamide, Androgen deprivation, Salvage radiation therapy
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Andrew J. Armstrong, MD
Prostate Cancer
Salvage Stereotactic Body Radiotherapy of the Prostate Bed for Biochemical Recurrence After Radical Prostatectomy.
This is a a randomized phase II/III trial comparing salvage SBRT with standard of care (SOC) regimens for patients with a persistent detectable PSA or biochemical progression during follow-up after radical prostatectomy.
- Trial name
- STEREOBED (NCT06523634)
- Testing
- Stereotactic body radiotherapy (SBRT), SOC RT
- Where
- 13 sites in Belgium
- Volunteers
- 284 people
- Sponsor
- Jules Bordet Institute
Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic
Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP
The postoperative incidence of catheter-related bladder discomfort (CRBD) ranges from 47% to 95%. It increases postoperative pain and agitation, thus requiring early intervention.
- Conditions
- Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic, Catheter-related Bladder Discomfort (CRBD)
- Trial name
- NCT07607990
- Testing
- Indomethacin suppository
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Prostate Cancer
Lidocaine Combined With Sufentanil for Preventing Catheter-related Bladder Discomfort
The goal of this clinical trial is to evaluate the incidence and severity of postoperative catheter-related bladder discomfort after robot-assisted radical prostatectomy.
- Trial name
- NCT05957653
- Testing
- lidocaine and sufentanil, Saline
- Volunteers
- 140 people
- Sponsor
- RenJi Hospital
Prostate Cancer (Post Prostatectomy), Urinary Continence
Analysis of Immediate Urinary Continence Predictors After RS-RARP
This study is a retrospective, single-center clinical trial. It aims to retrospectively analyze the immediate postoperative urinary continence recovery in prostate cancer patients who underwent Retzius-sparing robot-assisted…
- Conditions
- Prostate Cancer (Post Prostatectomy), Urinary Continence, Retzius-sparing Robot-assisted Radical Prostatectomy
- Trial name
- NCT06850116
- Testing
- Retzius-sparing robot-assisted radical prostatectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prostate Cancer
SAKK 08/15 - PROMET - Salvage Radiotherapy +/- Metformin for Patients With Prostate Cancer After Prostatectomy
The main objective of the trial is to explore the efficacy of salvage radiotherapy (SRT) plus metformin compared to SRT in the endpoint of time to progression after prostatectomy failure.
- Trial name
- NCT02945813
- Testing
- Metformin, Salvage Radiotherapy SRT
- Where
- 27 sites in France, Germany and 1 more
- Volunteers
- 112 people
- Sponsor
- Swiss Cancer Institute
Prostate Cancer
Study of Peri-Operative Docetaxel Plus Laparoscopic Radical Prostatectomy in Prostate Cancer Patients
This is a prospective phase II study of peri-operative docetaxel plus laparoscopic radical prostatectomy in patients with localized Gleason 7 pT2a-pT2b adenocarcinoma of the prostate and a risk of relapse after radical…
- Trial name
- NCT00127088
- Testing
- docetaxel, laparoscopic radical prostatectomy
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Prostate Cancer
A Study of Immediate 9 Months Adjuvant Hormone Therapy With Triptorelin 11.25 mg Versus Active Surveillance After Radical Prostatectomy in High Risk Prostate Cancer Patients.
The purpose of this study is to assess the benefit of immediate hormonal treatment after Radical Prostatectomy in Chinese and Russian patients with high risk prostate cancer.
- Trial name
- PRIORITI (NCT01753297)
- Testing
- Triptorelin 11.25 mg
- Where
- 18 sites in China, Russia
- Volunteers
- 226 people
- Sponsor
- Ipsen
Prostatic Neoplasms, Prostatectomy
Evaluating the Effect of the VCD on Erectile Function and Penile Length Post RRP
The purpose of this study is to perform a randomized prospective study to evaluate whether the vacuum erection device facilitates an earlier return of erectile function post radical prostatectomy.
- Trial name
- NCT00177125
- Testing
- ErectAid
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- University of Minnesota
Prostate Cancer, Robotic Prostatectomy
Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort
The indwelling urethral foley is a major source of discomfort following radical prostatectomy. Our hypothesis is that intra-operative dorsal penile nerve block with bupivacaine may decrease immediate post-operative foley…
- Conditions
- Prostate Cancer, Robotic Prostatectomy, Foley Catheter Discomfort
- Trial name
- NCT01565512
- Testing
- Bupivacaine, Saline
- Where
- United States
- Sponsor
- Columbia University
Cancer Of Prostate, Prostate Neoplasms
Highly Conformal, Hypofractionated, Focally Dose Escalated Post-Prostatectomy Radiotherapy
Background: Sometimes prostate cancer comes back after a person's prostate is removed. In this case, radiation is a common treatment. Radiation kills prostate cancer cells. It can be very effective.
- Conditions
- Cancer Of Prostate, Prostate Neoplasms, Prostate Cancer, Neoplasms of Prostate
- Trial name
- NCT03388619
- Testing
- Prostate bed with integrated boost, Prostate bed irradiation only, Whole Body Bone Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Prostatic Neoplasm
Early Salvage Stereotactic Radiotherapy for Biochemical Failure After RP
After radical prostatectomy, 30-60% of patients will develop recurrent disease. Salvage radiotherapy, usually at 2 Gy per fraction, is the main treatment option for these patients.
- Trial name
- esSBRT (NCT05667636)
- Testing
- salvage SBRT
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- Regina Elena Cancer Institute
Prostatectomy, Prostate Cancer
Physical Activity Intervention in African American Men After Radical Prostatectomy
The purpose of this pilot study is to evaluate the feasibility of recruiting African American prostate cancer survivors to a 12 week physical activity intervention study of three arms (aerobics, resistance training, and usual…
- Trial name
- NCT02621684
- Testing
- Community Health Activities Model Program for Seniors (CHAMPS), Lifetime Total Physical Activity Questionnaire, Expanded Prostate Cancer Index Composite (EPIC)
- Sponsor
- Washington University School of Medicine
Prostatic Neoplasms
Genomics and Efficacy of Post-prostatectomy Salvage Radiotherapy With 'Extreme' Hypofractionation
The study aims to validate the Decipher® genomic test, in which patients with biochemical recurrence after radical prostatectomy are treated with salvage radiotherapy with extreme hypofractionation (5+ Gy/fraction).
- Trial name
- NCT06894628
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- Regina Elena Cancer Institute
Prostate Cancer, Urinary Tract Infection
Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy
The aim of this study is to determine whether antibiotics prophylaxis at the time of urinary catheter removal decreases the number of symptomatic urinary tract infections in patients after radical prostatectomy.
- Conditions
- Prostate Cancer, Urinary Tract Infection, Clostridium Difficile
- Trial name
- Abx (NCT02247960)
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Rochester