Clinical trials: Prostatectomy
Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer
Multimodal Prehabilitation and Rehabilitation for Men Undergoing Robot-Assisted Radical Prostatectomy
Prostate cancer is the most common cancer in Australian men. Robot-assisted radical prostatectomy (RARP) - surgical removal of the prostate - is a standard treatment, but it frequently causes erectile dysfunction (ED) and urinary…
- Conditions
- Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer, Urinary Incontinence Following Surgical Procedure
- Trial name
- ROBOPREP (NCT07576335)
- Testing
- Tadalafil 5 mg, Pelvic Floor Muscle Training (PFMT), Aerobic Exercise Program
- Where
- 3 sites in Australia
- Volunteers
- 64 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Urinary Incontinence (UI), Prostatectomy
Transcutaneous Tibial Nerve Stimulation for Urinary Incontinence After Radical Prostatectomy
Urinary incontinence (UI) after radical prostatectomy (RP) is a common postoperative complication that significantly affects quality of life.
- Trial name
- NCT07742176
- Testing
- Active Transcutaneous Tibial Nerve Stimulation (TTNS), Pelvic Floor Muscle Training (PFMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Pamukkale University
Urinary Incontinence , Stress, Prostatectomy
Effect of High-Intensity Focused Electromagnetic (HIFEM) Technology in the Treatment of SUI in Chinese Men Undergone Robotic Radical Prostatectomy
This is a prospective, randomized trial to evaluate the efficacy and safety of High-Intensity Focused Electromagnetic (HIFEM) Technology in the treatment of stress urinary incontinence compared with standard of care in Chinese…
- Trial name
- NCT06589869
- Testing
- EM Chair, Standard of care
- Where
- Hong Kong
- Volunteers
- 184 people
- Sponsor
- Chinese University of Hong Kong
Overactive Bladder, Urinary Urgency Incontinence
Sacral Neuromodulation for Male Overactive Bladder (MOAB)
To assess the post-market clinical outcomes of the Axonics SNM System for treatment of overactive bladder in male patients.
- Conditions
- Overactive Bladder, Urinary Urgency Incontinence, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06511141
- Testing
- Axonics SNM System
- Where
- 23 sites in United States
- Volunteers
- 150 people
- Sponsor
- Axonics, Inc.
Perioperative Pain in Robotic Prostatectomy
Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy
Tramadol and magnesium have already been researched in recent decades for their different roles in pain control. This clinical study will compare and re-evaluate their effect on the duration and quality of analgesia provided by a…
- Trial name
- NCT07289321
- Testing
- Ultrasound - guided bilateral transversus abdominis plane block (TAP) in patients undergoing robotic-assisted radical prostatectomy.
- Where
- Greece
- Volunteers
- 105 people
- Sponsor
- Aretaieion University Hospital
Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction
Platelet-Rich Plasma for Erectile Dysfunction After Radical Prostatectomy: a Randomized Controlled Trial
This study will test whether injections of platelet-rich plasma (PRP) can improve erectile function in men with persistent erectile dysfunction (ED) at least 12 months after nerve-sparing radical prostatectomy for prostate…
- Trial name
- NCT07863388
- Testing
- Autologous Platelet Rich Plasma
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Herlev and Gentofte Hospital
Prostate Cancer (Post Prostatectomy), Urinary Incontinence
Effects of Hypopressive Exercises on Urinary Incontinence and Erectile Dysfunction After Radical Prostatectomy
This randomized controlled trial investigates the effects of hypopressive exercises on urinary incontinence and erectile dysfunction in men following radical prostatectomy.
- Conditions
- Prostate Cancer (Post Prostatectomy), Urinary Incontinence, Erectile Dysfunction Following Radical Prostatectomy, Pelvic Floor Muscle Training
- Trial name
- NCT07101731
- Testing
- Pelvic Floor Muscle Training (PFMT), Hypopressive Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bartın Unıversity
Urinary Incontinence, Prostatectomy
Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy
Urinary incontinence is a common complication following prostatectomy and affects a substantial proportion of patients. Despite advances in surgical technique, many patients experience persistent symptoms that negatively impact…
- Trial name
- NCT07534696
- Testing
- Non-invasive pelvic floor neuromuscular stimulation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, Los Angeles
Cerebral Hemodynamics, Mechanical Ventilation Strategies
Cerebral Hemodynamic Effects of Individualized PEEP During Robotic Prostatectomy
This randomized clinical trial will compare two approaches to setting positive end-expiratory pressure (PEEP) during robot-assisted radical prostatectomy performed in the Trendelenburg position.
- Conditions
- Cerebral Hemodynamics, Mechanical Ventilation Strategies, Robotic Prostatectomy
- Trial name
- NCT07784010
- Testing
- Individualized PEEP Titration, Standard PEEP Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Radical Prostatectomy, Stress Urinary Incontinence (SUI)
Pivotal Study of Voro Urologic Scaffold
The objective of this study is to compare safety and effectiveness of the Voro Urologic Scaffold in adult men undergoing robotic assisted radical prostatectomy as compared to control arm.
- Trial name
- ARID II (NCT06873581)
- Testing
- Voro Urologic Scaffold
- Where
- 19 sites in United States
- Volunteers
- 266 people
- Sponsor
- Levee Medical, Inc.
Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy
Tractography-Guided Nerve-Sparing in Prostate Cancer
Radical prostatectomy (RP) is an effective treatment leading to a high rate of oncological control. However, despite advances in robot-assisted RP, the genito-urinary function, especially erectile function and urinary continence…
- Conditions
- Prostate Cancer, Erectile Dysfunction Following Radical Prostatectomy, Urinary Incontinence Following Surgical Procedure
- Trial name
- PRO-TRACT (NCT07847385)
- Testing
- Prostate Tractography for Nerve-Sparing
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Massimo Valerio
Erectile Dysfunction Following Radical Prostatectomy
Safety and Tolerability of a Novel Implantable Device for the Treatment of Erectile Dysfunction
The goal of this clinical trial is to assess if a new device is safe to use as a potential treatment for erectile dysfunction following radical prostatectomy.
- Trial name
- NCT05650866
- Testing
- Activation of pro-erectile nerves within the pelvic plexus
- Where
- 4 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Comphya Australia
Post Prostatectomy Incontinence, Erectile Dysfunction Following Radical Prostatectomy
Pelvic Floor Muscle Training With Aerobic Exercise and Relaxation After Radical Prostatectomy
Post-prostatectomy urinary incontinence (PP-UI) and erectile dysfunction (ED) are common complications after radical prostatectomy, negatively affecting quality of life.
- Trial name
- PFMTinPPUI (NCT07172854)
- Testing
- Pelvic Floor Muscle Training, Aerobic Exercise, Relaxation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Hacettepe University
Prostate Cancer (Post Prostatectomy), Prostate Cancer
RIsk aDapted Stereotactic Radiotherapy vs. standarD of Care Radiotherapy in Patients With Prostate Cancer in the Adjuvant or saLvage sEtting With or Without Lymph Node Irradiation (RIDDLELN) - A Phase III Trial
The goal of this clinical trial is to determine whether stereotactic body radiotherapy (SBRT) delivered in five fractions is non-inferior to standard-of-care mildly hypofractionated radiotherapy in terms of patient-reported…
- Conditions
- Prostate Cancer (Post Prostatectomy), Prostate Cancer, SBRT
- Trial name
- RIDDLELN (NCT07830511)
- Testing
- Stereotactic body radiotherapy (SBRT) to the prostate bed, Standard-of-care radiotherapy (SOC) to the prostate bed
- Volunteers
- 206 people
- Sponsor
- Robert Förster
Postpartum Bladder Dysfunction, Post-prostatectomy Bladder Dysfunction
Exploring Clinical Utility of Wearables for the Bladder in Pelvic Health Physical Therapy Clinics
Pelvic health physical therapy (PHPT) is an evidence-based intervention for bladder dysfunction (BD) and pelvic floor disorders (PFD) in men postprostatectomy, and postpartum women.
- Conditions
- Postpartum Bladder Dysfunction, Post-prostatectomy Bladder Dysfunction, Bladder Dysfunction
- Trial name
- ClinicWeB (NCT07451106)
- Testing
- DFree Non-Invasive Bladder Ultrasound, Perifit Kegel Exerciser, Exit interview
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Robotic Radical Perineal Prostatectomy
Robotic Radical Perineal Prostatectomy Study
Radical perineal prostatectomy (RPP) was the first approach utilized for the removal of the entire prostate gland for prostate cancer.
- Trial name
- NCT04919057
- Testing
- GelPOINT®
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer, Optic Nerve Sheath Diameter
Effect Of Trendelenburg Position And Pneumoperitoneum On Optic Nerve Sheath Diameter In Robot-Assisted Prostatectomy
This prospective study aims to evaluate the effect of steep Trendelenburg position and pneumoperitoneum on optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic radical prostatectomy and open radical…
- Conditions
- Prostate Cancer, Optic Nerve Sheath Diameter, Robot-Assisted Radical Prostatectomy, Steep Trendelenburg Position With Penumoperitoneum in Robot Assisted Laparoscopic Prostatectomy
- Trial name
- ONSD-RALP (NCT07491198)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ege University
Prostate Cancer, Robotic Radical Prostatectomy
Hemodynamic Monitoring-Guided Goal-Directed Fluid Therapy in Robotic Radical Prostatectomy
This prospective observational cohort study evaluated goal-directed fluid therapy guided by minimally invasive hemodynamic monitoring in adult male patients undergoing elective robotic radical prostatectomy.
- Trial name
- NCT07806539
- Testing
- LiDCO-guided goal-directed fluid therapy, Conventional fluid therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Antalya Training and Research Hospital
Erectile Dysfunction Following Radical Prostatectomy
Efficacy of RestoreX Penile Traction Therapy In Preserving Erectile Function Post-Prostatectomy
Evaluate the efficacy of the RestoreX penile traction device in preserving erectile function in men undergoing robotic-assisted prostatectomy.
- Trial name
- NCT05244486
- Testing
- RestoreX 1-6 months (randomized phase), RestoreX 6-9 months (open label phase)
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Charitable Union for the Research and Education of Peyronie's Disease
Prostate Cancer, Radical Prostatectomy
A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy
To learn about the safety and effects of a drug called REGN5678 when it is given to patients with high-risk prostate cancer.
- Trial name
- NCT06085664
- Testing
- REGN5678, Piflufolastat F18
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- M.D. Anderson Cancer Center