Clinical trials: Prostatectomy
Erectile Dysfunction Due to General Medical Condition, Erectile Dysfunction Following Radical Prostatectomy
Platelet Rich Plasma (PRP) as Terapeutical Option in Erectil Disfunction (DE)
Patients are randomized into 2 groups (A and B), subsequently group A is subjected to a cycle of 6 weekly injections of 3 ml of autologous PRP while group B is subjected to 6 weekly injections of 1 ml of caverject (alprostadil)…
- Conditions
- Erectile Dysfunction Due to General Medical Condition, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Associated With Type 2 Diabetes Mellitus, Erectile Dysfunctions
- Trial name
- NCT06768177
- Testing
- PRP injection, Alprostadil 20 micrograms
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Prostate Cancer
68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks
Patients with primary prostate cancer (low, intermediate or high metastatic risk) for whom radical prostatectomy is indicated, will be invited to participate to the present study.
- Trial name
- UROPET (NCT03604757)
- Testing
- 68Ga-PSMA-617 PET/CT, 68Ga-RM2 PET/CT
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Prostate Cancer
CAPSAICIN Trial: Assessing Capsaicin as a Chemopreventive Agent for Prostate Cancer
The purpose of this study is to determine the chemopreventive properties of capsaicin, the active compound in chili peppers, in prostate cancer patients enrolled in the active surveillance program or patients scheduled to undergo…
- Trial name
- CAPSAICIN (NCT02037464)
- Testing
- Capsaicin Supplement (Cayenne by Nature's Way)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Erectile Dysfunction
Shockwave Therapy on Treating Erectile Dysfunction Following Nerve-sparing Radical Prostatectomy.
This study will investigate whether low-intensity extracorporeal shockwave therapy (LiESWT) can help men recover erectile function after nerve-sparing prostate cancer surgery.
- Trial name
- REVIVE (NCT07819084)
- Testing
- Low-Intensity Extracorporeal Shockwave Therapy, Standard of Care
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Prostate Cancer
Combination Chemotherapy Followed by Surgery in Treating Patients With Localized Prostate Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving chemotherapy before surgery may shrink the tumor so that it can be…
- Trial name
- NCT00017563
- Testing
- docetaxel, mitoxantrone hydrochloride, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- OHSU Knight Cancer Institute
Prostate Cancer
Degarelix Neo-Adjuvant Radical Prostatectomy Trial
To assess the effect of neo-adjuvant GnRH antagonist, degarelix, versus LHRH agonist on intratumoral levels of androgens.
- Trial name
- NCT01674270
- Testing
- Degarelix, Casodex, LHRH Agonist
- Where
- 2 sites in Canada
- Volunteers
- 35 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
11C Acetate Imaging Post Prostatectomy
This research is being conducted to test an imaging technique that may be able to detect small amounts of prostate cancer that can not be detected by standard imaging.
- Trial name
- NCT01602783
- Testing
- 11C Acetate Imaging
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer
Study to Allow for Second Treatment Cycle of DCVAC in Patients With Localized Prostate Cancer
The purpose of this study is to assess the safety of the second cycle of DCVAC/PCa in patients who completed the first cycle of DCVAC/PCa in the clinical trial SP003 without an objective progression of the disease.
- Trial name
- NCT02137746
- Testing
- Dendritic Cells DCVAC/PCa
- Where
- 7 sites in Czechia
- Volunteers
- 24 people
- Sponsor
- SOTIO a.s.
Prostate Neoplasm
MRI Targeted Focal Laser Thermal Therapy of Prostate Cancer Followed by Radical Prostatectomy
This is a clinical research study designed to measure the effectiveness of focal Interstitial Laser Thermal Therapy (ILTT) at killing prostate tumours.
- Trial name
- NCT00805883
- Testing
- Focal Phothtermal Ablation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Pain, Postoperative
Ultrasound Guided Pudendal Block in Transurethral Prostatectomies
The pudendal nerve conveys sensory, motor, sympathetic fibres to the perineum, bladder neck and proximal urethra. Pain management during transurethral procedures is a major concern.Patients who have been catheterized under…
- Trial name
- NCT01501279
- Testing
- Pudendal nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Diskapi Teaching and Research Hospital
Prostate Cancer
Study to Evaluate 99mTc-MIP-1404 SPECT/CT Imaging in Men With Biopsy Proven Low-Grade Prostate Cancer
99mTc-MIP-1404 is a radioactive diagnostic imaging agent indicated for imaging men with newly diagnosed prostate cancer whose biopsy indicates a histopathologic Gleason Score of ≤ 3+4 severity who are candidates for active…
- Trial name
- proSPECT-AS (NCT02615067)
- Testing
- 99mTc-MIP-1404 Injection, Whole-Body Planar and pelvic SPECT/CT scan
- Where
- 45 sites in United States, Canada
- Volunteers
- 531 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Prostate Cancer, PSMA PET/CT
Brief Title: INTROSPECT: Intraoperative PSMA PET/CT Imaging During Radical Prostatectomy
During prostate cancer surgery, the surgeon aims to remove the tumor completely while preserving the surrounding tissue responsible for urinary continence and sexual potency.
- Conditions
- Prostate Cancer, PSMA PET/CT, Margin Assessment
- Trial name
- INTROSPECT (NCT07829068)
- Testing
- study-specific administration of 68Ga-PSMA-11 followed by ex vivo PET/CT imaging of the prostatectomy specimen
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Cancer, Prostate Cancer
Statin Therapy Versus Placebo Prior to Prostatectomy
This is a randomized trial comparing the effect of oral simvastatin versus placebo on targets of the mevalonate pathway in men undergoing a prostatectomy as planned management for prostate cancer.
- Trial name
- NCT00572468
- Testing
- Simvastatin
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Prostatic Neoplasms, Prostatectomy
a Study of Combined mpMRI and PSMA PET/CT for Highly Suspicious Patients Performing Radical Prostatectomy Without Biopsy
This is an observational, open, single-arm, prospective, staged entry（based on Fleming's Group-Sequential Design） clinical study The Goal is to evaluate the feasibility and clinical value of direct robot assisted laparoscopic…
- Conditions
- Prostatic Neoplasms, Prostatectomy, Prostate Biopsy
- Trial name
- NCT05670691
- Volunteers
- 71 people
- Sponsor
- Fudan University
Prostate Cancer, Male Erectile Disorder
ED Recovery in Men Age </=65 Treated With Bilateral Nerve Sparing Robotic Assisted Prostatectomy for Prostate Cancer
RATIONALE: Sildenafil citrate and alprostadil may help patients who have undergone prostatectomy for prostate cancer to recover from erectile dysfunction.
- Conditions
- Prostate Cancer, Male Erectile Disorder, Stage I Prostate Cancer, Stage II Prostate Cancer
- Trial name
- NCT00544076
- Testing
- sildenafil citrate, alprostadil, robotic-assisted laparoscopic surgery
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer, Anesthesia, Local
Open Radical Prostatectomy and Erector Spinae Plane Block
In the proposed study, a bilateral erector spinae plane (ESP) block [10 ml 1%lidocaine + 10 ml 0.5 % bupivacaine vs normal saline (NS)] will be performed preoperatively to patients undergoing open radical prostatectomy.
- Conditions
- Prostate Cancer, Anesthesia, Local, Pain, Postoperative
- Trial name
- NCT04337060
- Testing
- Single-injection ultrasound-guided bilateral erector spinae plane block-Lidocaine/Bupivacaine, Pain follow-up and monitorization
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- BURHAN DOST
Adenocarcinoma of the Prostate
A Study of VEGF Tyrosine Kinase Inhibitor (Pazopanib) in Men With High-Risk Prostate Cancer Followed by Radical Prostatectomy and Pelvic Lymph Node Dissection
The area around a tumor ("pre-metastatic niche") may be an area to which cancer cells are attracted. The study doctor will take blood and tumor samples to look for certain features linked with response to treatment so that they…
- Trial name
- NCT01832259
- Testing
- Pazopanib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Prostate Cancer
R-Flurbiprofen in Treating Patients With Localized Prostate Cancer at Risk of Recurrence
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. R-flurbiprofen may be effective in delaying the recurrence of localized prostate cancer.
- Trial name
- NCT00045123
- Testing
- tarenflurbil, adjuvant therapy
- Where
- 58 sites in United States
- Sponsor
- Myrexis Inc.
Prostatic Cancer, Prostatic Neoplasm
Open Anterograde Radical Prostatectomy Compared to Open Retrograde Technique
Prospective randomized study performing open anterograde anatomical radical retropubic prostatectomy (RRP2A) using the same technique of minimally invasive surgery described by the Pasadena consensus for the procedure assisted by…
- Trial name
- RRP2A (NCT02687308)
- Testing
- 1 Retrograde radical prostatectomy RRP, 2 Anterograde radical prostatectomy RRP2A
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Rio de Janeiro State University
Kidney Cancer, Prostate Cancer
Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic Surgery
Controlling pain is fundamental during and after surgical procedures. This study examines pain associated with robotic assisted surgery on prostate cancer or a kidney mass.
- Trial name
- NCT03824808
- Testing
- Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution, 0.9% Sodium Chloride Injection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Missouri-Columbia