Clinical trials: Prostatectomy, open to volunteers
Prostate Cancer (Post Prostatectomy), Bladder Cancer
Adaptive Radiotherapy for Genitourinary Cancers
The goal of this clinical trial is to learn if adaptive radiation boost works to treat genitourinary cancers, esp. in the context of prostate cancer patients with post-prostatectomy local relapse and bladder cancer patients with…
- Trial name
- SMART-B01 (NCT07324798)
- Testing
- adaptive RT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Prostate Cancer
Bilateral Versus Unilateral Lymph Node Dissection in High-Risk Prostate Cancer (BALANCE)
BALANCE is a multicenter, prospective, randomized controlled trial enrolling men with unilateral high-risk localized prostate cancer identified by prostate biopsy, multiparametric MRI, and PSMA PET imaging.
- Trial name
- BALANCE (NCT07580196)
- Testing
- Unilateral Extended Pelvic Lymph Node Dissection, Bilateral Extended Pelvic Lymph Node Dissection
- Where
- 14 sites in Italy
- Volunteers
- 820 people
- Sponsor
- University of Turin, Italy
Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer
Multimodal Prehabilitation and Rehabilitation for Men Undergoing Robot-Assisted Radical Prostatectomy
Prostate cancer is the most common cancer in Australian men. Robot-assisted radical prostatectomy (RARP) - surgical removal of the prostate - is a standard treatment, but it frequently causes erectile dysfunction (ED) and urinary…
- Conditions
- Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer, Urinary Incontinence Following Surgical Procedure
- Trial name
- ROBOPREP (NCT07576335)
- Testing
- Tadalafil 5 mg, Pelvic Floor Muscle Training (PFMT), Aerobic Exercise Program
- Where
- 3 sites in Australia
- Volunteers
- 64 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Benign Prostatic Hyperplasia With Outflow Obstruction
Short Term Outcomes Of Bipolar Prostate Resection (BPR) Versus Diode Laser Ablation Versus Holmium Laser Enucleation Of Prostate Above 80 Grams With Minimum One Year Follow Up Duration.
Randomized Controlled Study Comparing Safety, Efficacy and Short Term Outcomes Of Bipolar Prostate Resection (BPR) Versus Diode Laser Ablation Versus Holmium Laser Enucleation Of Prostate Above 80 Grams With Minimum One Year…
- Trial name
- NCT07410390
- Testing
- bipolar resection of the prostate, holimum laser enucleation of the prostate, diode laser ablation of the prostate
- Volunteers
- 105 people
- Sponsor
- Ain Shams University
Men Who Have Undergone Prostatectomy
Postural Training for Standing and Sitting in Men Suffering From Post-prostatectomy Urinary Incontinence
Existing research highlights the difficulty of identifying an optimal rehabilitation technique for improving male urinary continence.
- Trial name
- EDULAPRO (NCT06842914)
- Testing
- postural training
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Rouen
Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic
Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP
The postoperative incidence of catheter-related bladder discomfort (CRBD) ranges from 47% to 95%. It increases postoperative pain and agitation, thus requiring early intervention.
- Conditions
- Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic, Catheter-related Bladder Discomfort (CRBD)
- Trial name
- NCT07607990
- Testing
- Indomethacin suppository
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Radical Prostatectomies, Rehabilitation Outcome
State of Play of Physiotherapy in the Postoperative Management of Prostate Cancer : Prospective, Monocentric, National Survey, Aiming to Explore the Technics of Physiotherapy (PREduKiné)
In France, a considerable number of radical prostactectomy for cancer is carried out every year.This number was estimated at 20.000 in 2016.This surgery may have negative impact on the continence's subjects and their quality of…
- Conditions
- Radical Prostatectomies, Rehabilitation Outcome, Prostate Cancer, Prostate Cancer Surgery
- Trial name
- PREduKiné (NCT06815055)
- Testing
- Quality of life questionnary
- Volunteers
- 510 people
- Sponsor
- Centre Hospitalier de Roubaix
Prostate Cancer
PSMA-PET to Guide Prostatectomy
In this study, 196 patients will be randomized 1:1 to either having only the standard of care MRI prior to surgery versus having the standard of care MRI and the PSMA PET scan.
- Trial name
- NCT05381103
- Testing
- PSMA-PET and SOC MRI, SOC MRI
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Five Eleven Pharma, Inc.
Prostate Cancer Patients Undergoing Radical Prostatectomy
Ejaculatory Behavior and Seminal Vesicle Size During Radical Prostatectomy
The goal of this clinical trial is to learn if recent ejaculation or abstinence before surgery affects seminal vesicle size and dissection-related surgical factors in adult men with prostate cancer undergoing radical…
- Trial name
- PreRP-EJAC (NCT07243795)
- Testing
- Recent Ejaculation, Preoperative Abstinence
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Prostate Cancer
Laparoscopic TAP Block During Robotic Assisted Laparoscopic Radical Prostatectomy for Improvement in Postoperative Pain
Determine the impact of a laparoscopic-guided transversus abdominis plane (TAP) block timing (at initiation or conclusion of procedure) on the postoperative pain experience in patients following robot assisted laparoscopic…
- Trial name
- TAPBlock (NCT05753046)
- Testing
- Early TAP Block, Late TAP Block
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Corewell Health East
Urinary Incontinence, Prostatectomy
Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy
Urinary incontinence is a common complication following prostatectomy and affects a substantial proportion of patients. Despite advances in surgical technique, many patients experience persistent symptoms that negatively impact…
- Trial name
- NCT07534696
- Testing
- Non-invasive pelvic floor neuromuscular stimulation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, Los Angeles
Bladder Cancer Requiring Cystectomy, Erectile Dysfunction Following Radical Prostatectomy
Pilot Study of a New Nerve Grafting Method During Bladder Cancer Surgery to Help Preserve Erections.
This pilot study will evaluate the safety and 1-year erectile function recovery in 10 patients undergoing a novel Nerve Restoring Radical Cystectomy (NR-RC), which includes a genitofemoral nerve graft.
- Trial name
- NR-RC (NCT07140588)
- Testing
- Patients undergoing radical cystectomy will receive a novel NR-RC procedure using a genitofemoral nerve graft to enhance erectile function recovery.
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Prostate Cancer (Adenocarcinoma), Renal Cancer
Comparison Between HUGO RAS Robotic Platform and Da Vinci Robotic Platform
The study is designed as a single-center, prospective, interventional, non-pharmacological, randomized, open-label, controlled trial with parallel groups.
- Trial name
- URO-ROBOT-2023 (NCT06844513)
- Testing
- Radical prostatectomy, Partial nephrectomy
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prostate Cancer
Safety and Efficacy of Two-step Radical Prostatectomy
The goal of this observational study is to learn about the safety and efficacy of two-step radical prostatectomy in the treatment of low- to intermediate-risk prostate cancer patient with enlarged prostate and severe benign…
- Trial name
- NCT05722392
- Testing
- Two-step Radical Prostatectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Prostate Cancer (Adenocarcinoma), Localized Prostate Cancer
68Ga-PSMA-11 PET/MRI for Selecting Men With Prostate Cancer for Focal Therapy
Focal therapy is a minimally invasive treatment option for some men with localized prostate cancer. Unlike surgery or radiation, focal therapy treats only the area of the prostate containing clinically significant cancer, with…
- Trial name
- PSMA-FT (NCT07747493)
- Testing
- Gallium Ga 68 Gozetotide (68Ga-PSMA-11), Intervention Description: Integrated positron emission tomography/magnetic resonance imaging (PET/MRI) combines molecular imaging with high-resolution anatomical MRI to evaluate intraprostatic lesions
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer Metastatic Disease
Radiotherapy or Surgery Combined With Intense Androgen Deprivation Therapy for mCRPC
This multi-center randomized controlled phase II trial was carried out in several hospitals in China to evaluate the efficacy and safety of radiotherapy or radical prostatectomy combined with intense androgen deprivation therapy…
- Trial name
- NCT06992232
- Testing
- Intense androgen deprivation therapy, Radiation Therapy, radical prostatectomy
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cerebral Perfusion Pressure, Trendelenburg
Evaluation of Cerebral Perfusion in Supine and Steep Trendelenburg Positions During Robotic Prostatectomy
Evaluation of Cerebral Perfusion in Supine and Steep Trendelenburg Positions During Robotic Prostatectomy Robotic endoscopic radical prostatectomy requires pneumoperitoneum and the steep Trendelenburg position to ensure optimal…
- Trial name
- NCT07317258
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hanife Kabukcu
Prostate Cancer Metastatic, Prostate Cancer
Dutch National Randomized Study: PSMA-PET/CT As a Triage Tool for Pelvic Lymph Node Dissection in Prostatectomy Patients
To determine if the use of Prostate-Specific Membrane Antigen Positron Emission Computer Tomography (PSMA PET/CT) as a selection tool for performing extended lymph node dissection (ePLND) for prostate cancer (PCa) in the primary…
- Conditions
- Prostate Cancer Metastatic, Prostate Cancer, Lymph Node Metastases
- Trial name
- PSMA-SELECT (NCT05000827)
- Testing
- PSMA-PET/CT, Nomogram
- Where
- Netherlands
- Volunteers
- 706 people
- Sponsor
- Canisius-Wilhelmina Hospital
Prostate Cancer
Outpatient Laparoscopic Radical Prostatectomy
The purpose of the study is to evaluate the incidence of surgery-related complications between Day 0 and Day 30.
- Trial name
- LORP (NCT05975775)
- Testing
- Laparoscopic radical prostatectomy
- Where
- France
- Volunteers
- 64 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Cerebral Hemodynamics, Mechanical Ventilation Strategies
Cerebral Hemodynamic Effects of Individualized PEEP During Robotic Prostatectomy
This randomized clinical trial will compare two approaches to setting positive end-expiratory pressure (PEEP) during robot-assisted radical prostatectomy performed in the Trendelenburg position.
- Conditions
- Cerebral Hemodynamics, Mechanical Ventilation Strategies, Robotic Prostatectomy
- Trial name
- NCT07784010
- Testing
- Individualized PEEP Titration, Standard PEEP Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University