Clinical trials: Prostatectomy
Prostate Cancer, Prostatectomy
Timing of Post-prostatectomy PSMA Imaging
The investigators will randomize patients presenting with early BCR with a negative baseline PSMA PET/CT, to upfront SRT or surveillance. Early BCR is defined as a PSA relapse of >0.1 to <0.3 ng/mL.
- Trial name
- TOPP (NCT05008900)
- Testing
- Salvage radiotherapy
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Prostatectomy
Magnesium Sulfate as an Adjunctive Analgesic in Prostate Surgery
The purpose of this clinical trial is to determine if receiving magnesium sulfate as an adjunctive analgesic for prostate surgery is effective in reducing pain.
- Trial name
- NCT06477133
- Testing
- Magnesium sulfate
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- NYU Langone Health
Prostate Cancer, Urinary Incontinence
Pre-Operative Nurse-Led Education With Direct Physiotherapy Referral to Reduce Post-Prostatectomy Incontinence
Urinary incontinence is a common complication following radical prostatectomy and can significantly impact quality of life. Pelvic floor physiotherapy is recommended to reduce post-operative incontinence; however, referral…
- Conditions
- Prostate Cancer, Urinary Incontinence, Postoperative Complications, Radical Prostatectomy
- Trial name
- PRO-ACT (NCT07426861)
- Testing
- Standard Pre-Operative Education and Physiotherapy Recommendation, Pre-Operative Nurse-Led Education with Direct Physiotherapy Referral
- Where
- Ireland
- Volunteers
- 80 people
- Sponsor
- Royal College of Surgeons, Ireland
Prostatectomy
Evaluating the Impact of Small Versus Large Urethral Stiches (or 'Bites') on Urinary Continence.
To evaluate the impact of sustainable functional urethral reconstruction (SFUR) on early recovery of urinary continence (UC) after robot-assisted radical prostatectomy.
- Trial name
- STITCH (NCT07226687)
- Testing
- Small Urethral Bite Technique, Large Urethral Bite Technique
- Where
- United States
- Sponsor
- University of Chicago
Prostate Cancer Patients Undergoing Radical Prostatectomy
PSMA-Targeted Intraoperative Fluorescent Imaging Agents (DGPR1008): Validation Across Different Time Windows
a Phase II, single-arm, open-label, multi-center study to evaluate safety, tolerability, pharmacokinetics, and the effectiveness of near-infrared fluorescence imaging during surgery.
- Trial name
- DGPR1008-04 (NCT07387510)
- Testing
- 12 h before RP, 24 h before RP, 36 h before RP
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Haitao Niu, MD
Prostate Cancer (Post Prostatectomy)
Salvage Ultrahypofractionated Postoperative External Radiotherapy For Biochemical Recurrence
Recently, the Radiation Oncology Department at Fondazione IRCCS San Gerardo dei Tintori has been renovated and has been equipped with cutting edge technologies to treat prostate cancer.
- Trial name
- SUPERB (NCT06941363)
- Testing
- SDRT
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milano Bicocca
Prostatectomy
A Comparison of Radical Prostatectomy and Precision Prostatectomy in Low- and Intermediate-risk Prostate Cancers.
Prostate cancer (PCa) management for low- and intermediate-risk patients often involves radical prostatectomy (RP), which achieves oncologic control but is associated with significant functional impairments, such as erectile…
- Trial name
- NCT07348367
- Testing
- Radical Prostatectomy, Precision Prostatectomy
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Henry Ford Health System
Transcutaneous Electrical Nerve Stimulation, Pudendal Neuralgia
Different Transcutaneous Electrical Nerve Stimulation Modes in Pudendal Neuralgia Post-prostatectomy
The purpose of this study was to evaluate the therapeutic efficacy of two different Transcutaneous Electrical Nerve Stimulation modes in improving the pudendal neuralgia and its intractable perineal pain.
- Conditions
- Transcutaneous Electrical Nerve Stimulation, Pudendal Neuralgia, Post Prostatectomy
- Trial name
- NCT07348952
- Testing
- conventional Transcutaneous Electrical Nerve Stimulation, Acupuncture-like) transcutaneous Electrical Nerve Stimulation, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Prostate Cancer, Radical Prostatectomy
Efficacy of the Pelvic Clock® Device for Functional Recovery After Robotic-Assisted Radical Prostatectomy
This randomized controlled trial evaluates the efficacy of the Pelvic Clock® device, a proprioceptive neuromuscular facilitation tool, in accelerating functional recovery following Robotic-Assisted Radical Prostatectomy (RARP).
- Trial name
- NCT07333807
- Testing
- Pelvic Clock®, Standard Pelvic Floor Muscle Training (PFMT)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Prostate Cancer (Post Prostatectomy), Bladder Cancer
Adaptive Radiotherapy for Genitourinary Cancers
The goal of this clinical trial is to learn if adaptive radiation boost works to treat genitourinary cancers, esp. in the context of prostate cancer patients with post-prostatectomy local relapse and bladder cancer patients with…
- Trial name
- SMART-B01 (NCT07324798)
- Testing
- adaptive RT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Prostate Cancer Patients Undergoing Radical Prostatectomy
Limited Versus Extended Lymph Node Dissection During Radical Prostatectomy in Patients With Localized or Locally Advanced Prostate Cancer
This is a randomized controlled study assessing outcome of low (no or limited) versus high (limited or extended) extent of lymph node dissection in addition to radical prostatectomy in patients with operable localized or locally…
- Trial name
- NCT07308990
- Testing
- Radical prostatectomy with extended / limited lymph node dissection, Radical prostatectomy with limited / no lymph node dissection
- Where
- Belarus
- Volunteers
- 800 people
- Sponsor
- N.N. Alexandrov National Cancer Centre
Urologic Cancer, Prostate
Comparison of the Integrated Posterior-Anterior-Lateral Approach and the Posterior Approach in Robotic Radical Prostatectomy
This study aims to compare perioperative, pathological, and early functional outcomes of PAL （Posterior, Anterior and Lateral）combined approach RARP and posterior approach (with Retzius space preserved) RARP in the treatment of…
- Conditions
- Urologic Cancer, Prostate, Robot Assisted Laparoscopic Radical Prostatectomy
- Trial name
- NCT07305142
- Testing
- PAL combined approach group, posterior approach group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Holmium Laser Prostate Surgery, Radical Prostatectomy
HIFEM Technology for Post-Radical Prostatectomy and Post-Holmium Laser Prostate Surgery
The purpose of this study is to evaluate the efficacy of High-Intensity Focused Electromagnetic (HIFEM) technology in improving the recovery time of urinary control and quality of life for male patients after radical…
- Trial name
- NCT06803602
- Testing
- EMSELLA®
- Where
- United States
- Volunteers
- 2,100 people
- Sponsor
- Mayo Clinic
Prostate Cancer Patients Undergoing Radical Prostatectomy
Ejaculatory Behavior and Seminal Vesicle Size During Radical Prostatectomy
The goal of this clinical trial is to learn if recent ejaculation or abstinence before surgery affects seminal vesicle size and dissection-related surgical factors in adult men with prostate cancer undergoing radical…
- Trial name
- PreRP-EJAC (NCT07243795)
- Testing
- Recent Ejaculation, Preoperative Abstinence
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Robot-Assisted Radical Prostatectomy, Prostatic Neoplasms
Effect of Changes in Endotracheal Tube Cuff Pressure on Postoperative Pharyngolaryngeal Complications in Robotic Surgery
The goal of this observational study is to evaluate how changes in endotracheal tube (ETT) cuff pressure during robot-assisted radical prostatectomy (RARP) affect postoperative throat-related symptoms.
- Trial name
- NCT07242144
- Testing
- Continuous Monitoring of Endotracheal Tube Cuff Pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ege University
Erectile Dysfunction Following Radical Prostatectomy
Safety and Tolerability of a Novel Implantable Device for the Treatment of Erectile Dysfunction
The goal of this clinical trial is to assess if a new device is safe to use as a potential treatment for erectile dysfunction following radical prostatectomy.
- Trial name
- NCT06968494
- Testing
- Activation of pro-erectile nerves within the pelvic plexus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Comphya Inc.
Erectile Dysfunction Due to General Medical Condition, Erectile Dysfunction Following Radical Prostatectomy
Platelet Rich Plasma (PRP) as Terapeutical Option in Erectil Disfunction (DE)
Patients are randomized into 2 groups (A and B), subsequently group A is subjected to a cycle of 6 weekly injections of 3 ml of autologous PRP while group B is subjected to 6 weekly injections of 1 ml of caverject (alprostadil)…
- Conditions
- Erectile Dysfunction Due to General Medical Condition, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Associated With Type 2 Diabetes Mellitus, Erectile Dysfunctions
- Trial name
- NCT06768177
- Testing
- PRP injection, Alprostadil 20 micrograms
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Stress Urinary Incontinence, Radical Prostatectomy
Data Collection Post Radical Prostatectomy
The study is designed to collect information on patients undergoing radical prostatectomy (RP), with a primary focus on the occurrence, duration, and severity of post-prostatectomy incontinence.
- Conditions
- Stress Urinary Incontinence, Radical Prostatectomy, BPH
- Trial name
- ALTO (NCT06351579)
- Testing
- Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Levee Medical, Inc.
Erectile Dysfunction, Erectile Dysfunction Associated With Type 2 Diabetes Mellitus
Regenerative Injection of Stem Cells or Stem Cell-derived Exosomes for Erectile Dysfunction (RISE)
The goal of this prospective observational study is to evaluate whether injections of stem cells derived from the patient's own fat tissue (adipose tissue) can improve erectile function in men aged 30 to 75 who have erectile…
- Conditions
- Erectile Dysfunction, Erectile Dysfunction Associated With Type 2 Diabetes Mellitus, Erectile Dysfunction Following Radical Prostatectomy
- Trial name
- RISE (NCT06605508)
- Testing
- Autologous Adipose Tissue-Derived Stem Cell Injection for Erectile Dysfunction, Stem cell-derived Exosomes Injection for Erectile Dysfunction
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Jumeirah American Clinic
Bladder Cancer Requiring Cystectomy, Erectile Dysfunction Following Radical Prostatectomy
Pilot Study of a New Nerve Grafting Method During Bladder Cancer Surgery to Help Preserve Erections.
This pilot study will evaluate the safety and 1-year erectile function recovery in 10 patients undergoing a novel Nerve Restoring Radical Cystectomy (NR-RC), which includes a genitofemoral nerve graft.
- Trial name
- NR-RC (NCT07140588)
- Testing
- Patients undergoing radical cystectomy will receive a novel NR-RC procedure using a genitofemoral nerve graft to enhance erectile function recovery.
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital