Clinical trials: Prostatic Biopsy
Clinically Significant Prostate Cancer
Plasma exoRNA-Based Liquid Biopsy to Diagnose Clinically Significant Prostate Cancer
The aim of the present study is to investigate a plasma exosome RNA signature to diagnose clinically significant prostate cancer.
- Trial name
- NCT07492927
- Where
- 10 sites in United States, China
- Volunteers
- 1,700 people
- Sponsor
- Xijing Hospital
Prostate Cancer
Comparative Analysis of Transperineal Versus Transrectal Approaches for MRI-Targeted Biopsy of the Prostate for the Detection and Characterization of Prostate Cancer
The purpose of this study is to investigate a transperineal biopsy approach (outside of the rectum) using MRI targeting to facilitate better access to the whole prostate gland and provide limited risk of infectious complications…
- Trial name
- NCT03366792
- Testing
- Artemis™ software system
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Prostate Cancer
European Multicenter Validation of PCaVision: A Head-to-Head Diagnostic Accuracy Study Comparing Multiparametric Transrectal Ultrasound to MRI for Clinically Significant Prostate Cancer Detection
The goal of this clinical trial is to learn if a new ultrasound-based imaging method (PCaVision) can accurately detect clinically significant prostate cancer in adult men (18 years and older) who are either undergoing initial…
- Trial name
- PCaVISTA (NCT06935487)
- Testing
- transrectal ultrasound of prostate (TRUS) with AI software algorithm, MRI prostate
- Where
- 10 sites in France, Germany and 4 more
- Volunteers
- 806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Prostate Cancer
The Accuracy of Modified TTMB in the Spatial Distribution of Prostate Cancer
Investigators plan to use modified TTMB technology to puncture prostate of participants suspected prostate cancer, especially those with the first negative biopsy , but having a rising PSA.Then, Investigators will simulate the…
- Trial name
- NCT03418207
- Testing
- trans-perineal template-guided mapping biopsy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Prostatic Neoplasms, Prostate Cancer
Multi-Center Trial of High-resolution Transrectal Ultrasound Versus Standard Low-resolution Transrectal Ultrasound for the Identification of Clinically Significant Prostate Cancer
This trial uses a ultra high-resolution ultrasound system and specialized transducer, intended for use in prostate imaging. The system's image resolution is significantly better than the standard of care, due to its higher…
- Conditions
- Prostatic Neoplasms, Prostate Cancer, Cancer of the Prostate
- Trial name
- NCT02079025
- Testing
- High-resolution ultrasound guided prostate biopsy, Standard ultrasound guided prostate biopsy
- Where
- 5 sites in United States, Canada
- Volunteers
- 1,676 people
- Sponsor
- Exact Imaging
Patients With Suspected Prostate Cancer
Multicentric Comparative Prospective Study of the Benefits and Risks of Biopsy Prostate Using Transrectal or Transperineal Procedure for the Prostate Cancer Diagnostic
The performance of prostatic biopsies is an essential element to confirm the diagnosis of prostate cancer and to specify the characteristics of the tumor in terms of stage and grade.
- Trial name
- BIOPROSTABORD (NCT05763355)
- Testing
- Biopsy
- Where
- 2 sites in France
- Volunteers
- 101 people
- Sponsor
- Elsan
Prostate Cancer
Performance of Prostate MRI and Following Biopsy to Detect Prostate Cancer Recurrence After Focal Therapy
The management of localized prostate cancer remains controversial because of a risk of over diagnosis and over treatment. Focal therapy represents an approach to improve the therapeutic ratio of prostate cancer treatments.
- Trial name
- IRMProft (NCT04773821)
- Testing
- Targeted biopsies
- Where
- 11 sites in France
- Volunteers
- 260 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Suspected Prostate Cancer
MRI Guided Prostate Biopsy
This study aims to assess the feasibility of magnetic resonance (MR) guided prostate biopsy using a needle holder frame. This frame is used to help position the needle used for the biopsy.
- Trial name
- NCT06302595
- Testing
- MRI-guided prostate biopsy using the needle holder frame.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Infectious Complications Following Prostate Biopsy, Prostate Cancer
A Study Comparing Infectious Complications After Transperineal Prostate Biopsy With or Without Antibiotic Prophylaxis
Prostate biopsy performed through the perineal skin (the area between the testicles and the anus), known as a transperineal biopsy, is currently considered the standard procedure for diagnosing prostate tumors, having replaced…
- Trial name
- NCT07557901
- Testing
- No antibiotic prophylaxis for prostate biopsy, Antibiotic prophylaxis (fosfomycin-trometamol) for prostate biopsy.
- Where
- Slovakia
- Volunteers
- 300 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Prostatic Neoplasm
Comparison of Multi-parametric and Bi-parametric Magnetic Resonance Imaging in Men With Suspicion of Prostate Cancer
To compare the detection rate of biparametric (bp) magnetic resonance imaging (MRI) for clinically significant prostate cancer (PCa) with that of multiparametric (mp)-MRI, in biopsy-naïve patients.
- Trial name
- NCT03693703
- Testing
- bi-parametric MRI, multi-parametric MRI
- Where
- Italy
- Volunteers
- 391 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Prostate Cancer
Prostate Cancer Detection Rates of Standard Transrectal Prostate Biopsy and MR-guided Fusion Transrectal Prostate Biopsy
Prostate cancer is the most frequent cancer in men. Today serum prostate specific antigen (PSA) level and digital rectal examination (DRE) are routinely used for screening of prostate cancer.
- Trial name
- NCT03936296
- Testing
- mpMR guided MR-US fusion transrectal prostate biopsy, 12 core standard transrectal prostate biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- TC Erciyes University
Prostate Cancer, Prostate Biopsy
TENS for Pain Relief During Fusion-Guided Prostate Biopsy
The goal of this clinical trial is to learn whether transcutaneous electrical nerve stimulation (TENS) can reduce pain during transperineal prostate biopsy in adult male patients.
- Conditions
- Prostate Cancer, Prostate Biopsy, Fusion Biopsy, Pain Management
- Trial name
- NCT07331246
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Local Anesthesia
- Where
- Poland
- Volunteers
- 84 people
- Sponsor
- Medical University of Gdansk
Prostate Cancer (Diagnosis), Prostate Cancer
INSIGHT-PCa: MRI- and PHI-Guided Risk-Adapted Strategy for Prostate Cancer Diagnosis
Prostate cancer diagnosis based on systematic or MRI-targeted biopsy is associated with substantial overdiagnosis and unnecessary invasive procedures.
- Trial name
- INSIGHT-PCa (NCT07398690)
- Testing
- Diagnostic Procedure
- Where
- South Korea
- Volunteers
- 1,432 people
- Sponsor
- In Gab Jeong, MD
Infection
PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy
Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora.
- Trial name
- PREVENT (NCT04843566)
- Testing
- Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis)
- Where
- 10 sites in United States
- Volunteers
- 687 people
- Sponsor
- Weill Medical College of Cornell University
Prostate Cancer
Carbon-11 Labeled Sarcosine in Prostate Cancer
Men with and without prostate cancer will have a PET/CT scan that measures the level of the amino acid sarcosine. PET is a scanning method that uses short lived radioactivity.
- Trial name
- NCT02462447
- Testing
- 11C-sarcosine, 11C-choline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Prostate Cancer
Prostate Cancer Detection Using the Stockholm3 Test and MR/Fusion Biopsies
The STHLM3-MRI trial is a study comparing traditional prostate cancer detection using PSA and systematic biopsies with the improved pipeline for prostate cancer detection using the STHLM3 test and targeted biopsies in a screening…
- Trial name
- STHLM3MR-2 (NCT03377881)
- Testing
- MRI/Fusion biopsies, Systematic biopsies
- Where
- 3 sites in Sweden
- Volunteers
- 12,750 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Prostate Cancer
PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures
The aim of this study is to assess the efficacy of MRI-targeted biopsy compared to standard of care systematic TRUS guided biopsy in the detection of clinically significant and clinically insignificant prostate cancer in men…
- Trial name
- PRECISE (NCT02936258)
- Testing
- Standard of Care, MRI, MRI Targeted Biopsy
- Where
- 5 sites in Canada
- Volunteers
- 450 people
- Sponsor
- Canadian Urology Research Consortium
Prostate Cancer Detection, Fusion Prostate Biopsy
Comparison of Prostate Fusion Biopsies With Software and Cognitive
This study evaluates the efficacy to diagnose significant prostate cancer in patients with suspicious lesions in mpMRI (multiparametric magnetic resonance imaging) by comparing prostate biopsies performed by cognitive fusion with…
- Trial name
- NCT04291742
- Testing
- cognitive vs software
- Where
- Spain
- Volunteers
- 804 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Prostatic Neoplasms
Evaluation of Diagnostic Value of 3-T Magnetic Resonance Imaging (MRI) in Suspected Prostate Cancer
The purpose of the study is to evaluate the usefulness of 3-T magnetic resonance imaging (MRI) in the evaluation of suspected prostate cancer.
- Trial name
- NCT01357512
- Testing
- magnetic resonance imaging, Siemens
- Where
- Finland
- Volunteers
- 130 people
- Sponsor
- University of Oulu
Prostate Cancer
Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial
This phase I/II trial examines if buffered lidocaine reduces the pain that patients may experience during prostate biopsy. Prostate biopsies are typically performed awake, in the office, with only local anesthetic.
- Trial name
- BURN (NCT06661902)
- Testing
- Buffered Lidocaine (1% Lidocaine + 8.4% Sodium Bicarbonate, in a 3:1 ratio), Lidocaine, Biopsy of Prostate
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Washington