Clinical trials: Prostatic Cancer
Prostate Cancer, Prostate Neoplasm
Robotic-arm Assisted 68 Ga PSMA PET/CT Guided Prostate Biopsy Versus MR Directed Cognitive Fusion TRUS Guided Prostate Biopsy (PROBIOP)
The present study aimed to compare the diagnostic accuracy, radiation exposure, complication rates between 68Ga-PSMA PET/CT guided robotic arm assisted prostate biopsy and MRI directed TRUS guided prostate biopsy in PIRADS 4/5…
- Trial name
- PROBIOP (NCT05137561)
- Testing
- PSMA PET guided prostate biopsy, MRI directed TRUS guided prostate biopsy
- Where
- India
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Thoracic Cancer, Ovarian Cancer
Project CADENCE (CAncer Detected Early caN be CurEd)
With existing evidence showing the difference in miRNA expression levels between non-cancer and cancer groups, the investigators assume that levels of DNA methylation, RNA expression as well as protein concentration will also be…
- Conditions
- Thoracic Cancer, Ovarian Cancer, Liver Cancer, Prostate Cancer
- Trial name
- CADENCE (NCT05633342)
- Where
- Singapore
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- MiRXES Pte Ltd
Prostate Cancer
Combined Prostate-specific Antigen, Multi-parametric MRI and Targeted Prostate Biopsy for Prostate Cancer Screening
The study aims to investigate the incidence of prostate cancer among males in Nanjing and whether a combination of PSA, multi-parametric MRI and targeted biopsy is a feasible approach for screening prostate cancer in China.
- Trial name
- NCT04322045
- Testing
- multi-parametric MRI
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Prostate Cancer, Healthy Donors
Comparative Study of Diagnostic and Prognosis Biomarkers of Prostate Cancer in Liquid Biopsy (HOPE)
Constitution of a biological collection within the framework of the establishment of a diagnostic, prognostic and active surveillance test for prostate cancer from long non-coding RNA biomarkers, in 3 cohorts of patients, with…
- Trial name
- HOPE (NCT05141383)
- Testing
- Urine sampling
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Institut Curie
Prostate Cancer
Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer
The aim of this project is to determine whether androgen deprivation therapy (ADT) decreases left ventricular function in prostate cancer patients.
- Trial name
- NCT03275181
- Testing
- Transthoracic Echocardiography, Arterial blood pressure, Submaximal Exercise
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Prostatic Neoplasms
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
Background: Insomnia is associated with difficulty sleeping. The drug zolpidem is widely prescribed for insomnia. Women have reported worse effects from the drug than men.
- Trial name
- NCT03436745
- Testing
- Zolpidem, ECG
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
PCMRI - an MRI/TRUS System for the Evaluation of the Prostate
The aim of the clinical study is to evaluate the convenience and efficacy of the PCMRI in the assessment of the prostate in humans.
- Trial name
- PCMRI (NCT00542100)
- Testing
- PCMRI
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TopSpin Medical
Prostate Cancer, Prostate Neoplasm
Early and Accurate Detection of Prostate Cancer in General Practice
Prostate cancer (PC) is the most common malignancy (4500 new cases/year) and the second leading cause of cancer-associated mortality (1200 deaths/year) among men in Denmark.
- Conditions
- Prostate Cancer, Prostate Neoplasm, Prostate Adenocarcinoma
- Trial name
- NCT03431753
- Testing
- PSA, STHLM3 and mpMRI for PC detection
- Where
- Denmark
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Prostatic Neoplasm of Uncertain Behavior
Combining High-frequency Micro-ultrasound and Multiparametric MRI Target Biopsy for Detecting Prostate Cancer
Study Goal: The purpose of this clinical trial is to determine if combining high-frequency micro-ultrasound with multiparametric MRI biopsy and a systematic biopsy can better detect clinically significant prostate cancer compared…
- Trial name
- Biopsy29 (NCT06579911)
- Testing
- High-frequency micro-ultrasound target biopsy, conventional Multiparametric MRT target biopsy
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Healthy Volunteers
Comparison of Explicit, Implicit and no Values Clarification Decision Aids for Men Considering Prostate Cancer Screening
The investigators aim at comparing the perceived clarity of personal values in men considering PSA screening using decision aids with no VCM versus an implicit VCM versus an explicit VCM.
- Trial name
- NCT03988673
- Testing
- Decision aid with implicit values clarification method (booklet or website), Decision aid with explicit values clarification method (booklet or website)
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Benign Prostatic Hyperplasia
Urolift Pre-SBRT for Reduced Urinary Toxicity in Patients With BPH and Prostate Cancer.
Many patients may face long-term urinary side effects following stereotactic body radiation therapy (SBRT), including increased urinary frequency, dysuria, and nocturia.
- Trial name
- NCT05148156
- Testing
- Urolift
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Prostate Cancer
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
Prostate cancer is the most common non-skin cancer among Veterans and the second leading cause of male cancer death. Current methods of screening men for prostate cancer are inaccurate and cannot identify which men do not have…
- Trial name
- ProGRESS (NCT05926102)
- Testing
- Precision screening intervention, Usual care
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cancer Survivor, Partner
Lifestyle Behavior Influences Among African American Patients With Stage 0-III Prostate Cancer Survivors and Their Partners
This trial studies the day-to-day stress, social support, and health lifestyle behaviors (such as physical activity and nutrition) in African American patients with stage 0-III prostate cancer survivors and their partners.
- Conditions
- Cancer Survivor, Partner, Spouse, Stage I Prostate Cancer AJCC v8
- Trial name
- NCT04189770
- Testing
- Accelerometer, Ecological Momentary Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Urinary Incontinence, Prostate Cancer
Perioperative Post-Prostatectomy Incontinence Home Telehealth Program
Many men develop urine leakage after prostate cancer surgery. Usually it is temporary, but pelvic floor muscle training and exercise (including urine control strategies) have been shown to reduce the time to regaining urine…
- Trial name
- ProsTel (NCT01960998)
- Testing
- Pelvic Floor Muscle Training, Perioperative Care and Wetness Management
- Where
- 3 sites in United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Prostate Cancer
Evaluation of a MRI-based Prostate Cancer Screening Program
The purpose of this study is to evaluate the effort and resources (incl. costs) required to detect 20 clinically relevant prostate cancer (PCA) in a screening program based on bpMRI of the prostate.
- Trial name
- VISIONING (NCT03749993)
- Testing
- Screening
- Where
- Switzerland
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Prostate Cancer
PSA TOOL for Prostate Cancer Screening Discussions
The study team created a tool to help identify patients who may benefit from shared decision making in the primary care setting. This tool is a guide to aid in decision making for prostate cancer screening.
- Trial name
- NCT03135444
- Testing
- PSA TOOL, Revised PSA TOOL, Informal Interview
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Role of Caregiver in the Clinical Pathway of Patients With Breast and Prostate Cancer
The following randomized longitudinal study will evaluate the long term impact of caregivers' involvement in cancer care pathway, including a psychological support intervention on the dyads to be delivered after the detection of…
- Trial name
- NCT06468293
- Testing
- Psychological support
- Where
- Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Prostate Cancer
Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer
The objective of this study is to determine if systemically infused allogeneic bone marrow derived mesenchymal stem cells (MSC) home to sites of prostate cancer in men with localized adenocarcinoma of the prostate that are…
- Trial name
- MSC (NCT01983709)
- Testing
- Allogeneic Human Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
Randomized Study Comparing MR-guided in Bore Versus MRI/US Fusion-guided Prostate Biopsy
The hypothesis of the study is that targeted MRI/US fusion-guided prostate biopsy with additional systematic transrectal ultrasound (TRUS)-guided biopsy significantly detects more prostate cancers than targeted MR-guided in-bore…
- Trial name
- NCT02220517
- Testing
- MR-guided in-bore prostate biopsy, MRI/US fusion-guided prostate biopsy
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Prostate Cancer, Genetic Predisposition to Disease
Prophylactic Prostatectomy for Prostate Cancer (PPPC)
Prostate cancer affects 1-in-8 people assigned male at birth in the UK and kills almost 12,000 annually. Half the cases occur due to genetic factors.
- Conditions
- Prostate Cancer, Genetic Predisposition to Disease, BRCA Mutation
- Trial name
- PPPC (NCT06470685)
- Testing
- Qualitative Research Interviews
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust