Clinical trials: Prostatic Disease
Prostate Cancer
Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)
Multiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decrease the rate of unnecessary…
- Trial name
- NCT05043012
- Testing
- flexible AIR coil, endorectal coi
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- M.D. Anderson Cancer Center
Adenocarcinoma of the Prostate, Stage IIA Prostate Cancer
Diffusion-Weighted MRI in Staging Patients With Localized Prostate Cancer
This pilot clinical trial studies how well diffusion-weighted magnetic resonance imaging (MRI) works in staging patients with prostate cancer that has not spread to nearby lymph nodes or other parts of the body.
- Conditions
- Adenocarcinoma of the Prostate, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- NCT02237612
- Testing
- diffusion-weighted magnetic resonance imaging, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Southern California
Accupuncture, Prostate Cancer
Comparing Acupuncture vs. Sham Acupuncture for the Management of Hot Flashes in Prostate Cancer Patients Receiving Hormone Therapy
This study is evaluating whether acupuncture may help reduce hot flashes in men receiving hormone therapy for prostate cancer. Hot flashes are a common side effect of androgen deprivation therapy (ADT) and may negatively affect…
- Conditions
- Accupuncture, Prostate Cancer, Hormone Therapy, Hot Flashes
- Trial name
- NCT07594002
- Testing
- Real Acupuncture
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kentucky
Prostatic Neoplasms
Surgery Versus Radiotherapy for Locally Advanced Prostate Cancer
This prospective, open randomized phase III surgical trial seeks to study whether radical prostatectomy (with or without the combination of external radiation) improves prostate-cancer specific survival in comparison with primary…
- Trial name
- SPCG-15 (NCT02102477)
- Testing
- Prostatectomy/Surgery, Radiotherapy with adjuvant androgen deprivation therapy
- Where
- 30 sites in Denmark, Finland and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Olof Akre
Prostate Cancers, Breast Cancer
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This registry study aims to evaluate the effectiveness and clinical impact of specimen PET-CT imaging by analyzing the correlation between specimen PET-CT images, intraoperative interpretations, and histopathological findings.
- Conditions
- Prostate Cancers, Breast Cancer, Head and Neck Cancer, Cancer
- Trial name
- PETRiS (NCT06970275)
- Where
- 5 sites in Belgium, Germany and 2 more
- Volunteers
- 850 people
- Sponsor
- XEOS Medical
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Urinary CTGF in Benign Prostatic Obstruction
Benign prostatic obstruction (BPO) is one of the most common causes of bladder outlet obstruction (BOO) and may lead to progressive structural and functional alterations in the bladder over time.
- Conditions
- Benign Prostatic Hyperplasia, Bladder Outlet Obstruction, Lower Urinary Tract Symptom
- Trial name
- NCT07416981
- Volunteers
- 50 people
- Sponsor
- Tarik Emre Sener
Prostate Cancer
High-intensity Focused Ultrasound Study
Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, including the risks of urinary…
- Trial name
- NCT03927924
- Testing
- High-intensity focused ultrasound
- Where
- Hong Kong
- Volunteers
- 5 people
- Sponsor
- Chinese University of Hong Kong
Oligometastatic Disease, Prostate Cancer
Percutaneous High-dose Radiotherapy in Patients With Oligometastases of Prostate Carcinoma
The purpose of this study is to evaluate the outcomes of patients treated with an high dose radiation regimen using either stereotactic hypofractionated or normofractionated radiotherapy for oligometastatic prostate cancer and to…
- Trial name
- Oli-P (NCT02264379)
- Testing
- normal fractionated irradiation, hypo fractionated irradiation
- Where
- 2 sites in Germany
- Volunteers
- 73 people
- Sponsor
- Technische Universität Dresden
Prostate Cancer
Radioactive Counts From PSMA PET/CT-Targeted Biopsy Specimens for Real-time Diagnosis of Prostate Cancer: A Prospective Study
This study aims to establish the diagnostic threshold and efficacy of radioactive counts (CPM) from biopsy specimens in distinguishing cancer-containing from non-cancer-containing cores, using prostate biopsy pathology as the…
- Trial name
- NCT07709403
- Testing
- No intervention (observational study)
- Volunteers
- 20 people
- Sponsor
- Peking University First Hospital
Prostate Cancer
Aberrant Gene Expression Prostate Carcinoma
The goal of the study is to gain a better understanding of the molecular changes responsible for causing prostate cancer and that examination of tissue and blood samples will help in the development of improved screening and…
- Trial name
- NCT00868803
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Lahey Clinic
Prostate Cancer
3T Perfluorocarbon-Filled Endorectal Magnetic Resonance Spectroscopic Imaging of Prostate
Objectives: The objectives of this study are to: 1) evaluate the feasibility of 3T MRSI of prostate in improving the spectral resolution, using a PFC-filled endorectal coil, 2) develop a systematic metabolic grading system for…
- Trial name
- NCT00464724
- Testing
- 3T Magnetic Resonance Spectroscopic Imaging
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Exercise, Prostate Cancer
A Comparison of Aerobic and Resistance Exercise to Counteract Treatment Side Effects in Men With Prostate Cancer
Prostate cancer is the second most common cancer in men. Those in the intermediate/high-risk categories typically receive androgen deprivation therapy (ADT) and radiotherapy.
- Trial name
- NCT05156424
- Testing
- Exercise
- Where
- Ireland
- Volunteers
- 24 people
- Sponsor
- Kira Murphy
Prostatic Hyperplasia
ALF-STONE: Alfuzosin in Uretheric Stones
The aim of the study is to assess the effect of Alfuzosin compared with placebo, for 7 days, on the outcome of patients with uretheric stones submitted to Extracorporeal Shock Wave Lithotripsy (ESWL), namely in the percentage of…
- Trial name
- NCT00454402
- Testing
- Alfuzosin
- Where
- Portugal
- Volunteers
- 220 people
- Sponsor
- Sanofi
Prostate Cancer
Unilateral Nerve-Sparing Cryoablation for Low-Risk, Clinically Localized, Unilateral Prostate Cancer
Men with low-risk, clinically localized, unilateral prostate cancer will be treated with unilateral nerve-sparing cryoablation and evaluated for the rate of potency, cancer control and health related quality of life outcomes…
- Trial name
- POTENT-C (NCT02459912)
- Testing
- Unilateral Nerve-Sparing Cryoablation of the Prostate, Precise Cryoablation System with IceRod Needles
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- NYU Langone Health
Prostate Cancer
Phase II, Dose Finding Study of GTx-758
The purpose of this study is to determine the appropriate loading and maintenance dose of GTx-758 to reach and maintain castration for the duration of the study.
- Trial name
- NCT01393119
- Testing
- GTx-758
- Where
- 21 sites in United States
- Volunteers
- 77 people
- Sponsor
- GTx
Prostate Cancer
Radical Radiotherapy by External Beam Radiation Versus Radical Radiotherapy With Temporary Iridium Implant Plus External Beam Radiation in Carcinoma of the Prostate
The specific objective of this study is to compare the relative efficacy of the combination of a temporary iridium implant plus external beam irradiation versus standard external beam irradiation alone in patients with Stage B2…
- Trial name
- NCT00548600
- Testing
- Iridium Implant, Standard external beam irradiation
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Prostate Cancer
An Epidemiological Study of Genetic Risk Factors for Prostate Cancer in African-American and Caucasian Males
This study will examine the association of genetic variants and gene expression patterns with the risk of prostate cancer. There will be (It will include?) genotype analysis of blood DNA from 600 patients with the disease and…
- Trial name
- NCT00342771
- Where
- 2 sites in United States
- Volunteers
- 2,033 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer (Post Prostatectomy)
The Application of Somatosensory Interactive Pelvic Floor Muscle Training for Stress Urinary Incontinence in Men Underwent Radical Prostatectomy
The study aims to compare the efficacy of different pelvic floor muscle training (PFMT) modes on improving urinary incontinence (UI) recovery in prostate cancer (PCa) patients after radical prostatectomy (RP).
- Trial name
- NCT06740071
- Testing
- somatosensory interactive pelvic floor muscle training, pelvic floor magnetic stimulation therapy, standard pelvic floor muscle training
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Metastatic Castration Resistant Prostate Cancer
Study of TAS3681 in Metastatic Castration Resistant Prostate Cancer
The purpose of this trial is to investigate the safety and tolerability of TAS3681, to find the maximum tolerated dose (MTD)/recommended dose of TAS3681 (Escalation Phase) and to further evaluate safety and preliminary efficacy…
- Trial name
- NCT02566772
- Testing
- TAS3681
- Where
- 33 sites in United States, France and 2 more
- Volunteers
- 130 people
- Sponsor
- Taiho Oncology, Inc.
Breast Neoplasms, Ovarian Neoplasms
Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer
The primary purpose of this study is to evaluate the safety, side effects, and dosage for Motexafin Gadolinium given with the chemotherapy drug docetaxel to patients with advanced cancers.
- Conditions
- Breast Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Lung Neoplasms
- Trial name
- NCT00120939
- Testing
- Motexafin Gadolinium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Pharmacyclics LLC.
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