Clinical trials: Prostatic Disease
Prostate Cancer
Immediate Versus Deferred Androgen Deprivation Therapy,Goserelin for Recurrent Prostate Cancer After Radical Radiotherapy
This is a prospective, multicentre, open-labelled, randomized controlled trial comparing the efficacy of immediate versus deferred androgen deprivation therapy (ADT) using goserelin (Zoladex®) in men with recurrent prostate…
- Trial name
- ELAAT (NCT00439751)
- Testing
- Goserelin Acetate
- Where
- 11 sites in Canada
- Volunteers
- 79 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Prostate Cancer, Prostatic Neoplasms
MR Image Guided Therapy in Prostate Cancer
Background: One way to treat prostate cancer is to use a laser to direct extreme heat to a small area of the prostate. The heat destroys tumor cells but does not affect healthy tissue.
- Trial name
- NCT01377753
- Testing
- Visualase Thermal Therapy System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Castration Resistant Prostate Cancer
A Phase 1 Study of Autologous Dendritic Cell Immunotherapy in Patients With mCRPC
The goal of this clinical trial was to evaluate the safety of Cellgram-DC-PC, an autologous dendritic cell-based cancer immunotherapy, in patients with metastatic castration-resistant prostate cancer (mCRPC).
- Trial name
- NCT04615845
- Testing
- Cellgram-DC-PC
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Pharmicell Co., Ltd.
Lower Urinary Tract Symptoms
The Efficacy of Nano-water in Combination With Tamsulosin- Dutasteride for Lower Urinary Tract Symptoms
The goal of this clinical trial is to learn if nano-water combined with tamsulosin and dutasteride can relieve the symptoms of lower urinary tract symptoms in adults with benign prostatic hyperplasia .
- Trial name
- NCT06677177
- Testing
- Nano-water, Tamsulosin Dutasteride, Regular water, tamsulosin, Dutasteride
- Where
- Iraq
- Volunteers
- 210 people
- Sponsor
- ALI KAMAL M. SAMI
Prostate Cancer
Improving Patient Understanding of Their Prostate Cancer Diagnosis Using AI
The purpose of this study is to determine if ChatGPT (an artificial intelligence driven chatbot) can help patients better understand their own pathology results and prostate cancer diagnosis.
- Trial name
- NCT07040501
- Testing
- Chat GPT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Rituximab Neoadjuvant Therapy in Patients With Prostate Cancer Scheduled to Undergo Radical Prostatectomy
There is now substantial evidence that B cells are recruited into prostate cancers by CXCL13 released by the tumor cells. B cells release lymphotoxin which drives malignant cell proliferation through the NFkB pathway.
- Trial name
- NCT01804712
- Testing
- rituximab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Christopher Kane
Prostate Cancer, Urinary Incontinence
An RCT to Compare Early Continence Recovery After RARP With or Without Sustainable Functional Urethral Reconstruction
The study is a prospective randomized controlled trail to compare early urinary continence recovery after robotic-assisted radical prostatectomy with or without sustainable functional urethral reconstruction (SFUR).
- Trial name
- NCT04037800
- Testing
- SFUR-RARP, Standard RARP
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Changhai Hospital
Hormone Refractory Prostate Cancer
A Study of Picoplatin and Docetaxel in Subjects With Prostate Cancer
This study will review the safety of picoplatin, a new type of platinum drug, with docetaxel, a drug commonly used in the treatment of prostate cancer.
- Trial name
- NCT00448734
- Testing
- Picoplatin, docetaxel
- Where
- 11 sites in Russia
- Volunteers
- 95 people
- Sponsor
- Poniard Pharmaceuticals
Prostate Cancer
Validation Study on the Impact of Decipher® Testing - VANDAAM Study
The primary purpose of this study is to determine whether a tumor test recently developed by GenomeDx Biosciences known as Decipher® can predict aggressive prostate cancer with the same accuracy in African-American men (AAM) as…
- Trial name
- VANDAAM (NCT02723734)
- Testing
- Decipher® Testing
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Overactive Bladder Syndrome, Bladder Outlet Obstruction
Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity
Urodynamic examination evaluates storage and empting phases of the urinary bladder. It enables the clinician to correlate physiologic findings to patients' complains.
- Conditions
- Overactive Bladder Syndrome, Bladder Outlet Obstruction, Benign Prostate Enlargement, Stress Incontinence (Female) (Male)
- Trial name
- NCT03486639
- Testing
- IPSS questionnaire
- Where
- Israel
- Volunteers
- 330 people
- Sponsor
- Assaf-Harofeh Medical Center
Benign Prostatic Hyperplasia
The Edison System for Treatment of Benign Prostatic Hyperplasia (BPH) Using Histotripsy
The purpose of this trial is to evaluate the safety of histotripsy using the HistoSonics Edison System for treatment of BPH.
- Trial name
- WOLVERINE (NCT07214675)
- Testing
- HistoSonics Edison System
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- HistoSonics, Inc.
Prostate Cancer
Single-center Trial for the Validation of High-resolution Transrectal Ultrasound (Exact Imaging Scanner ExactVu) for the Detection of Prostate Cancer
The primary objective of this study is to evaluate the performance of HR-TRUS in detection of prostate cancer lesions relative to whole mount section after radical prostatectomy as the reference.
- Trial name
- EXACTVU (NCT03679819)
- Testing
- HR-TRUS
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Institut Paoli-Calmettes
Prostate Cancer
Combination Immunotherapy in Biochemically Recurrent Prostate Cancer
Background: Some people with prostate cancer have a rise in prostate-specific antigen (PSA). This can happen even after treatments like radiation and surgery.
- Trial name
- NCT03315871
- Testing
- Antigen direct immunotherapy: PROSTVAC-V, Antigen direct immunotherapy: PROSTVAC-F, MSB0011359C (M7824)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
PSA Vaccine Therapy in Treating Patients With Advanced Prostate Cancer
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of different regimens of PSA vaccines in treating patients who have advanced…
- Trial name
- NCT00003871
- Testing
- fowlpox virus vaccine vector, recombinant vaccinia prostate-specific antigen vaccine
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Eastern Cooperative Oncology Group
Prostate Cancer
Intermittent Treatment With Degarelix of Patients Suffering From Prostate Cancer
The purpose of this uncontrolled, multi-center, open-label trial was to investigate the feasibility of using degarelix as intermittent androgen deprivation (IAD) therapy in the treatment of prostate cancer.
- Trial name
- NCT00801242
- Testing
- Degarelix 240 mg / 80 mg
- Where
- 52 sites in Belgium, France and 4 more
- Volunteers
- 220 people
- Sponsor
- Ferring Pharmaceuticals
Metastatic Cancer, Pain
Single-Dose Local Radiation Therapy Compared With Ibandronate in Treating Patients With Localized Metastatic Bone Pain
RATIONALE: Ibandronate may be effective in reducing bone pain caused by metastatic cancer. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Metastatic Cancer, Pain, Prostate Cancer
- Trial name
- NCT00082927
- Testing
- ibandronate sodium
- Where
- 52 sites in United Kingdom
- Volunteers
- 580 people
- Sponsor
- Cancer Research UK
Prostate Cancer
Image-guided, Tumor-focused Radiotherapy Treatment in Intermediate and High-risk Prostate Cancer
This is a phase II non-blinded randomized controlled trial of image-guided, tumor-focused radiotherapy in patients with intermediate- or high-risk prostate cancer planning to undergo definitive radiotherapy with or without…
- Trial name
- RadTARGET (NCT06990542)
- Testing
- Image-guided tumor-focused radiation therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Diego
Prostate Cancer
Immune Monitoring on Sipuleucel-T
The purpose of this protocol is perform comprehensive immune monitoring studies in patients with castration-resistant prostate cancer receiving Sipuleucel-T in an effort to better understand the mechanism of action of this…
- Trial name
- PROVENGE (NCT02237170)
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prostate Cancer
Soccer Intervention in Prostate Cancer Survivors
This study seeks to directly test the implementation feasibility of a soccer-based and lifestyle education intervention to determine the effects on bone health, body composition, mental health, functional and cardiometabolic…
- Trial name
- NCT04144127
- Testing
- Soccer
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Prostate Carcinoma, Prostate Small Cell Neuroendocrine Carcinoma
Autologous T Cells Lentivirally Transduced to Express L1CAM-Specific Chimeric Antigen Receptors in Treating Patients With Locally Advanced and Unresectable or Metastatic Small Cell Neuroendocrine Prostate Cancer
This phase I trial studies the side effects and best dose of autologous CD8+ and CD4+ lentivirally transduced to express L1CAM-specific chimeric antigen receptor (CAR) and EGFRt mutation specific T cells and to see how well they…
- Conditions
- Prostate Carcinoma, Prostate Small Cell Neuroendocrine Carcinoma, Stage III Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT06094842
- Testing
- Bendamustine, Biopsy, Biospecimen Collection
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.