Clinical trials: Prosthetic, open to volunteers
Reconstruction of Massive Bone Loss (Oncologic and Non-oncologic)
Prospective Evaluation of Adler Laboratory's Massive Prosthetic Implants in Oncological and Non-oncological Situations
Massive prostheses are the standard treatment for extensive bone loss, whether caused by cancer or other factors (complex fractures, multiple revisions, infections).
- Trial name
- IMPULSION (NCT07369778)
- Where
- France
- Volunteers
- 375 people
- Sponsor
- Nantes University Hospital
Para-prosthetic Heart
Para-Prosthetic Valve Leak Closure Observatory - PVLC2
Para-prosthetic heart valve leakage is an evolving complication after surgical or percutaneous heart valve replacement. These leaks can lead to heart failure and/or life-threatening hemolysis.
- Trial name
- FFPP2 (NCT07049991)
- Testing
- surgical or percutaneous heart valve replacement.
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis
Safety and Performance Assessment of the SYMBOL Range of Medical Devices in Patients Underlying Total Hip Arthroplasty
The purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the SYMBOL range of medical devices.
- Conditions
- Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis, Hip Arthritis, Femoral Neck Fractures
- Trial name
- NCT05227924
- Testing
- Total hip arthroplasty (primary or revision)
- Where
- 9 sites in France
- Volunteers
- 747 people
- Sponsor
- Dedienne Sante S.A.S.
Joint Arthroplasty, Shoulder
Reduction of Bacterial Seeding in Total Shoulder Arthroplasty
The purpose of this study is to compare the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus Prontosan wound gel applied to the skin…
- Conditions
- Joint Arthroplasty, Shoulder, Cutibacterium Acnes, Prosthetic Joint Infection
- Trial name
- NCT07406893
- Testing
- Prontosan Wound Gel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Amputation
Pro APP Prosthetic Outcome Registry
A national, multi-center registry of patients using lower-limb prosthesis, their profiles and devices, and their long-term follow-up and clinical outcomes.
- Trial name
- NCT06210620
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Össur Iceland ehf
Heart Valve Diseases
The Study of Biological Prosthetic Heart Valves With the "Easy Change" System
The study of new biological heart valves with the "easy change" system, including an assessment of the basic hemodynamic characteristics of the prosthesis, complications associated with valve implantation, and general mortality
- Trial name
- NCT04442100
- Testing
- valve prosthetics
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Depression - Major Depressive Disorder
The Effect of PROSE or Scleral Lenses on Mental Health
The goal of this prospective clinical trial is to evaluate the effect that prosthetic replacement of the ocular surface ecosystem (PROSE, BostonSight, Needham MA) treatment may have on mental health, particularly affective mood…
- Trial name
- NCT07195721
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Sight
Prosthetic Joint Infection, Debridement With Prosthesis Retention
Antibiotic-coated Braided Suture Study
The purpose of this study is to evaluate whether the use of antibiotic-coated (triclosan) braided sutures is non-inferior or potentially superior to standard monofilament sutures in patients with prosthetic joint infections…
- Conditions
- Prosthetic Joint Infection, Debridement With Prosthesis Retention, Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
- Trial name
- NCT07322289
- Testing
- VICRYL™ Plus (Coated VICRYL™ Plus Antibacterial), Polydioxanone (PDS™ II ) Sterile Synthetic Absorbable Surgical Suture-Monofilament
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Miami
Infections Joint Prosthetic, Overweight or Obesity
Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk…
- Conditions
- Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA
- Trial name
- NCT04297592
- Testing
- Cephalexin, Doxycycline, Cefadroxil
- Where
- 2 sites in United States
- Volunteers
- 4,618 people
- Sponsor
- Mayo Clinic
Prosthesis User, Prosthesis
Optimize Pattern Recognition Control of Powered Upper Limb Prosthesis
This study is focused on optimizing methods for controlling upper-limb myoelectric prosthetic arms. If you are enrolled in this study you would be expected to visit one of the research sites for approximately 5 in-lab visits…
- Conditions
- Prosthesis User, Prosthesis, Prosthetic, Upper Limb Amputation
- Trial name
- NCT07850544
- Testing
- Condition A: Electrode Configuration, Condition B: Electrode Configuration, Condition C: Electrode Configuration
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Liberating Technologies, Inc.
Bone Loss
Prosthetic Modality and MBL
The present study will test the effect of different prosthetic modalities on conical and internal hex connection implants, assessing the radiographic MBL changes after one year.
- Trial name
- NCT07156110
- Testing
- Traditional prosthetic procedure, one abutment-one time
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo
Prosthetic Joint Infection
Study of the Lived Experience of Patients With Prosthetic Joint Infection, Their Families, and Healthcare Professionals. Development of a Therapeutic Education Program for Patient Care (TEP).
The PROTHEE-QUALI study (Qualitative study of the lived experience of patients with prosthetic joint infection, their accompanying persons and health professionals and construction of a therapeutic education program for…
- Trial name
- PROTHEE-QUALI (NCT07409402)
- Testing
- Exploration of the lived experience of patients with prosthetic joint infection (PJI), their families, and healthcare professionals
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transtibial Amputation
Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1
The goal of this clinical trial is to 1) demonstrate the feasibility of monitoring pressure, temperature, and lactic acid density of sweat inside the prosthetic socket, and 2) verify the relationship between mechanical pressure…
- Trial name
- NCT07216183
- Testing
- Walk, Yuga post, E-SWEAT Sensor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- North Carolina State University
Partial Edentulism, Dental Implant
Immediate vs Conventional Loading With Different Crown Materials on Immediately Placed Single Implants
This randomized controlled trial compares immediate and conventional loading of single implants placed immediately into fresh extraction sockets in the upper front and premolar region.
- Conditions
- Partial Edentulism, Dental Implant, Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement
- Trial name
- NCT07882095
- Testing
- Conventional loading, Monolithic zirconia crown, Permanent 3D-printed PMMA crown
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Bone Tumor
Evaluation of Tumor Resection and Reconstruction With Prosthetic Implants
Bone can be the site of primary malignant tumors or, more commonly, secondary lesions. The most frequent primary tumors are osteosarcoma, chondrosarcoma, and Ewing sarcoma, whereas the malignancies that most commonly metastasize…
- Trial name
- RERIO (NCT07337018)
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infections Joint Prosthetic
Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections
Cutibacterium acnes is involved in nearly 40% of shoulder prosthetic joint infections (PJI). After shoulder prothesis, C. acnes mainly affects hip prosthesis.
- Trial name
- RIFACute (NCT05902221)
- Testing
- amoxicillin or moxifloxacin, amoxicillin or moxifloxacin + rifampicin
- Where
- 13 sites in France
- Volunteers
- 235 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aortic Infections and Inflammations, Mycotic Aneurysm
Study of the Aortic and Large Arterial Vessel Infections
Aortic or large arterial vessel infections are rare but serious infections. Their management is based on French and American expert opinions.
- Conditions
- Aortic Infections and Inflammations, Mycotic Aneurysm, Arterial Infections and Inflammations, Prosthetic Infection
- Trial name
- Repia (NCT05660733)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Central Hospital, Nancy, France
Prosthetic-joint Infection
SHort Interval Full Two-stage Implant Exchange
This study is a prospective bicentric feasibility study, which aims to evaluate the feasibility of a two-stage full implant exchange with early prosthesis reimplantation between 16 and 30 days after implants removal for hip or…
- Trial name
- SHIFT (NCT05642013)
- Testing
- Early prosthesis reimplantation, Retrospective analysis of medical records
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Prosthetic-joint Infection, Infection Hip
Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection
In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin…
- Conditions
- Prosthetic-joint Infection, Infection Hip, Infection; Knee, Joint
- Trial name
- RiCOTTA (NCT06172010)
- Testing
- Clindamycin, Rifampicin and levofloxacin
- Where
- 13 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- Leiden University Medical Center
Complete Edentulism
Prosthetic Complications in Full-arch Screw-retained Implant Restorations Using Monolithic Zirconia Versus Titanium Frameworks: A Randomized Clinical Trial
The goal of this clinical trial is to to compare the prosthetic complication rate and Oral Health-Related Quality of Life (OHRQoL) between screw-retained monolithic zirconia frameworks and CNC-milled titanium frameworks with…
- Trial name
- NCT07657364
- Testing
- Monolithic Zirconia Prosthesis, CNC-milled titanium framework and zirconia superstructure
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University