Clinical trials: Prosthetic-joint Infection
Periprosthetic Joint Infection (PJI)
Preop Biomarkers as Outcome Predictors in 2 Stage Revision Surgery for PJI
With the progressive ageing of the population, a significant increase in the incidence of skeletal fractures-particularly of the proximal femur-as well as degenerative conditions such as osteoarthritis has been observed, for…
- Trial name
- ARKO-PJI (NCT07358455)
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prosthetic Joint Infection, Prosthetic Infection
Calprotectin in Chronic Prosthetic Joint Infection
A bacterial infection of an artificial joint is a serious complication that often requires additional surgery to exchange the arthroplasty.
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Arthroplasty Complications
- Trial name
- NCT05060952
- Testing
- Calprotectin Lateral Flow Test
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Hip Prosthetic Joint Infection, Knee Prosthetic Joint Infection
Short Interval in Treatment of PJI
Patients with hip, knee and shoulder PJI, will be treated with a two-stage exchange Revision. Patients will be randomized into 2 groups: the experimental Group will get a reimplantation after a short interval (2-3 weeks) while…
- Conditions
- Hip Prosthetic Joint Infection, Knee Prosthetic Joint Infection, Shoulder Prosthetic Joint Infection
- Trial name
- Fast-track (NCT02372435)
- Testing
- Shortening of the interval of two-stage prosthesis exchange
- Volunteers
- 418 people
- Sponsor
- Charite University, Berlin, Germany
Prosthetic Joint Infection
Alpha Defensin and 16S rRNA Gene in Diagnosis of PJI
Total joint replacement is considered one of the most successful surgical procedures in the field of orthopedics. Despite this achievement, prosthetic joint infections is still considered a severe complication often leading to…
- Trial name
- NCT03714165
- Testing
- Alpha defensin and 16SrRNA gene
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Prosthetic Joint Infection, Unicompartmental Knee Arthroplasty
Metal Artifact Reduction Sequence MRI for Surgical Decision-Making in Infected Unicompartmental Knee Arthroplasty
A single-center retrospective cohort study was conducted in the Department of Orthopedics of Fujian Medical University Affiliated First Hospital.
- Trial name
- NCT07208968
- Where
- China
- Volunteers
- 28 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prosthetic Joint Infection
New Molecular Approaches for Diagnosis of Prosthetic Joint Infection
The goals of this observational study are: 1. to evaluate the concordance between traditional method (culture) and genomic method in diagnosing prosthetic joint infections; 2.
- Trial name
- NCT06670885
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Joint Arthroplasty, Shoulder
Reduction of Bacterial Seeding in Total Shoulder Arthroplasty
The purpose of this study is to compare the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus Prontosan wound gel applied to the skin…
- Conditions
- Joint Arthroplasty, Shoulder, Cutibacterium Acnes, Prosthetic Joint Infection
- Trial name
- NCT07406893
- Testing
- Prontosan Wound Gel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Bone Tumours, Bone Infection
Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection
Translational research aimed at improving diagnostic accuracy of musculoskeletal infection and musculoskeletal tumours using machine learning applied to clinical data, histopathological sections and genomic sequencing.
- Conditions
- Bone Tumours, Bone Infection, Prosthetic Joint Infection, Prosthetic Infection
- Trial name
- AIortho (NCT04746001)
- Testing
- Genomic sequencing, Histological examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Prosthetic Joint Infection
NGS vs Culture Outcomes for Treatment of PJI
This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.
- Trial name
- NCT05247281
- Testing
- Culture-based treatment, Next Generation Sequencing (NGS) with Culture
- Where
- 9 sites in United States
- Volunteers
- 250 people
- Sponsor
- Center for Innovation and Research Organization
Prosthetic Joint Infection
Cohort of Prosthetic Joint Infections
Management of prosthetic joint infections (PJI) is a challenging task. These infections include different clinical and microbiological settings calling upon various treatment strategies according to infection type (acute or…
- Trial name
- COPINS (NCT02801253)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Total Knee Arthroplasty, Prosthetic-joint Infection
Methylene Blue in Total Knee Arthroplasty (TKA)
The purpose of this pilot study is to determine the volume of irrigation required to achieve macroscopic clearance of contaminants during a debridement, antibiotics, and implant retention (DAIR) procedure for periprosthetic joint…
- Conditions
- Total Knee Arthroplasty, Prosthetic-joint Infection, Irrigation
- Trial name
- NCT07324954
- Testing
- Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Osteoarticular Infections, Intensive Care Patients
Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.
This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated…
- Conditions
- Osteoarticular Infections, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS² (NCT07107685)
- Testing
- Global cohort
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prosthetic-joint Infection
Surgiphor vs Saline Joints
This study will be an open-label superiority, multicenter, single-blind, controlled randomized clinical trial investing the role of a PVP-I irrigation solution (Surgiphor) in reducing the risk of acute PJI in the 90 days…
- Trial name
- NCT05434260
- Testing
- Surgiphor Irrigation Solution, Sterile saline
- Where
- 4 sites in United States
- Volunteers
- 868 people
- Sponsor
- Center for Innovation and Research Organization
Prosthetic Joint Infection
Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection
The PROOF Study is an open prospective interventional non-randomized study which aim is to determine the outcome / effect and safety of fosfomycin in patients with hip, knee or shoulder PJI.
- Trial name
- PROOF (NCT03260010)
- Testing
- Fosfomycin
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Pro-Implant Foundation
Prosthetic Joint Infection of Knee
Sola2 AMF Knee System Added to Surgery and Antibiotics in Adults With Knee Implant Infection
The goal of this clinical trial is to learn whether the Sola2 AMF Knee System, when added to surgery and antibiotic treatment, can safely improve outcomes, knee function, and quality of life in adults with knee implant infection.
- Trial name
- AMPLIFY (NCT07700927)
- Testing
- Intervention 1: Alternating Magnetic Field Treatment, Debridement, Antibiotics, Implant Retention
- Volunteers
- 165 people
- Sponsor
- Solenic Medical, Inc.
Corynebacterium Infections
Corynebacterium Spp Bone and Joint Infection: Retrospective Study of Microbiological, Diagnostic and Therapeutic Features
Corynebacterium spp have been considered as innocuous commensals of human skin, but are now accepted as important opportunistic pathogens responsible for various nosocomial infections, especially implicating foreign materials.
- Trial name
- NCT03081273
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Hospices Civils de Lyon
Infections Joint Prosthetic
Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections
Cutibacterium acnes is involved in nearly 40% of shoulder prosthetic joint infections (PJI). After shoulder prothesis, C. acnes mainly affects hip prosthesis.
- Trial name
- RIFACute (NCT05902221)
- Testing
- amoxicillin or moxifloxacin, amoxicillin or moxifloxacin + rifampicin
- Where
- 13 sites in France
- Volunteers
- 235 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
ROADMAP Clinical Trial
Artificial joint infections are treated with different types of antibiotics and surgery. The ROADMAP study aims to find out which treatments currently used work best in regards to surgery, antibiotic choice as well as the time…
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Large Joint Prosthetic Joint Infections
- Trial name
- ROADMAP (NCT06771050)
- Testing
- Debridement and Implant Retention (DAIR), Antibiotic Choice, Antibiotic duration Part A - Single stage revision
- Where
- 43 sites in Australia, New Zealand
- Volunteers
- 2,500 people
- Sponsor
- University of Newcastle, Australia
Prosthetic Joint Infection, Staphylococcus
Clindamycin in Prosthetic Joint Infections Caused by Staphylococcus (CISTA)
The alternatives to the combination of Fluoroquinolone and Rifampicin in prosthetic joint infections (PJI) caused by staphylococcus are currently unclear.
- Trial name
- CISTA (NCT04946500)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Periprosthetic Fracture Around Prosthetic Joint Implant
Investigating Periprosthetic Fracture Cultures in Arthroplasty
This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment…
- Trial name
- NCT06952738
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago