Clinical trials: Protein Digestion
Protein Metabolism, Colorectal Neoplasms
Whey Protein-based Enteral Nutrition Support to Improve Protein Economy in Surgical Patients
A prospective, randomized and controlled study is proposed to establish whether an enteral nutrition support regimen based on pressurized whey protein and glucose improves the postoperative utilization of amino acid substrates…
- Trial name
- NCT01276795
- Testing
- Oral Nutrition Support
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Crohn's Disease
Immune Response Regulation and Nutritional Status of the Crohn's Disease Patients.
The objective of this study was to evaluate the effect of Whey Protein (WP) and Soy Protein (SP) nutritional supplements on nutritional status and disease activity in Crohn's disease patients.
- Trial name
- NCT01957423
- Testing
- Whey protein, Soy protein
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Campinas, Brazil
Liver Transplantation, Hepatocellular Carcinoma
Assessment of AFP and PIVKA-II as Prognostic Indicators in Liver Transplantation for Hepatocellular Carcinoma
As key biomarkers in HCC, AFP and PIVKA-II reflects biological features of tumor and has been widely applied for clinical diagnosis.
- Conditions
- Liver Transplantation, Hepatocellular Carcinoma, Alpha-Fetoprotein, Protein Induced by Vitamin K Absence or Antagonist-II
- Trial name
- NCT06331260
- Volunteers
- 600 people
- Sponsor
- Zhejiang University
Neoplasm Metastasis
Study of PF-07265807 in Participants With Metastatic Solid Tumors.
A First-in-Human Pharmacokinetic, Safety, and Tolerability Study of PF-07265807 as Monotherapy and in Combination in Participants with Advanced or Metastatic Solid Tumors
- Trial name
- NCT04458259
- Testing
- PF-07265807, Sasanlimab, Axitinib
- Where
- 33 sites in United States, Canada and 3 more
- Volunteers
- 88 people
- Sponsor
- Pfizer
Advanced Solid Tumor, Metastatic Cancer
Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers
The purpose of the Phase 1/2a study is to evaluate the safety and tolerability of SNK01 in combination with trastuzumab or cetuximab in order to determine the maximum tolerated dose (MTD)/recommended Phase 2 dose (RP2D), and the…
- Conditions
- Advanced Solid Tumor, Metastatic Cancer, HER2-positive Breast Cancer, HER2-positive Gastric Cancer
- Trial name
- NCT04464967
- Testing
- SNK01, Trastuzumab, Cetuximab
- Sponsor
- NKGen Biotech, Inc.
Individual Difference, Food Sensitivity
Investigation of the Perception of Protein Fortified Foods and Beverages
This study aims to investigate whether protein fortification of foods and beverages causes mouthdrying and mucoadhesion and whether this is influenced by age and saliva flow.
- Conditions
- Individual Difference, Food Sensitivity, Food Preferences
- Trial name
- NCT03798730
- Testing
- Solid Model, Liquid Model
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Reading
Liver Cirrhosis
Safety and Tolerability Study of OP-724 in Liver Cirrhosis Patients by HIV/HCV with Hemophilia.
To evaluate the safety and tolerability of OP-724 in liver cirrhosis patients caused by HIV/HCV co-infection with hemophilia.
- Trial name
- NCT04688034
- Testing
- OP-724
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Kiminori Kimura, MD
Celiac Disease
Effects of Gluten Digestion With ALV003
This is a Phase 0, Double-blind study that will assess the effect of in vitro treatment of gluten with ALV003 or with placebo when ingested by CD Subjects.
- Trial name
- 0801 (NCT00859391)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Alvine Pharmaceuticals Inc.
Aging, Appetite Loss
Effect of a Novel Protein Ingredient Combined With Oral Nutritional Supplement on Appetite in Older Adults
Reduced appetite can occur with ageing and is linked to a higher risk of undernutrition, poorer physical function and becoming frail. Strategies to increase appetite are needed to improve healthy ageing.
- Conditions
- Aging, Appetite Loss, Undernutrition
- Trial name
- NCT06478147
- Testing
- Oral Nutritional Supplement, Oral Nutritional Supplement + Whey Protein Hydrolysate, Whey Protein Hydrolysate + still water
- Where
- Ireland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Protein Digestion & Absorption
The Impact of Milk Protein Glycation on Protein Digestion and Absorption
Rationale: Protein intake is an essential stimulus for muscle protein anabolism. The muscle protein synthetic response to protein ingestion is mainly determined by the post-prandial plasma amino acid response.
- Trial name
- VerLys (NCT05479916)
- Testing
- Low glycated milk protein, High glycated milk protein
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pancreatic Cancer
Vaccine Therapy in Treating Patients With Stage I or Stage II Pancreatic Cancer
RATIONALE: Vaccines made from a person's cancer cells may make the body build an immune response to and kill tumor cells. Combining vaccine therapy with surgery may be an effective treatment for pancreatic cancer.
- Trial name
- NCT00003025
- Testing
- vitespen
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Post-infectious Irritable Bowel Syndrome, Irritable Bowel Syndrome
Characterizing Protein Biomarkers of Post-infection Irritable Bowel Syndrome
The investigators will characterize and compare protein signatures between groups with and without post-infection irritable bowel syndrome (PI-IBS).
- Trial name
- NCT06032117
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Probiotics
Use of a Selected Mixture of Probiotic Strains for Degrading Gluten During Digestion
Gluten intake spreads worldwide, being the major food protein consumed in the Western diets (up to 20 g gluten/d). But gluten has unique and unusual features.
- Trial name
- NCT05798689
- Testing
- Probiotic administration and gluten
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Free University of Bozen-Bolzano
Carcinoma, Hepatocellular
90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia
This clinical trial will compare 1-year outcomes in patients with hypoalbuminemia and a new diagnosis of small, early-stage hepatocellular carcinoma (HCC) who are candidates for both 90-Yittrium Therasphere transarterial…
- Trial name
- REALM (NCT05953961)
- Testing
- Therasphere 90Y, Microwave Ablation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ochsner Health System
Cholangiocarcinoma, Colorectal Cancer
Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid
The overall goal of the randomized control trial (RCT) will be to evaluate the efficacy of modifications to a web-based tool for patient decision-making regarding return of genomic results that will more closely focus on rare…
- Conditions
- Cholangiocarcinoma, Colorectal Cancer, Multiple Myeloma
- Trial name
- NCT06910670
- Testing
- Standard developed materials, Genetics Advisor Decision Aid
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Washington University School of Medicine
Intestinal Obstruction, Colorectal Cancer
Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction
Despite modern approaches to the diagnosis and treatment of acute bowel obstruction (ABO), postoperative mortality ranges from 5 to 32%, and complications occur up 23% of cases.
- Conditions
- Intestinal Obstruction, Colorectal Cancer, Post-Op Complication, Systemic Inflammatory Response Syndrome
- Trial name
- NCT05229822
- Testing
- LBP, sCD14-ST, 16s rRNA
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- Karaganda Medical University
Pancreatic Cancer
SBRT and Anti-programmed Cell Death Protein 1(Anti-PD-1) in Late Stage or Recurrent Pancreatic Cancer Patients
When gemcitabine based chemo and fluorouracil based chemo regimes are failed in late-stage or recurrent pancreatic cancer patients, there is no alternative options. Anti-PD-1 antibody has became a promising anti-cancer drug.
- Trial name
- CISPD-2 (NCT03716596)
- Testing
- SBRT, anti-PD-1 antibody
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Ipilimumab and Local Radiation for Selected Solid Tumors
This pilot phase 1-2 trial studies the side effects and best of dose ipilimumab when given together with local radiation therapy and to see how well it works in treating patients with recurrent melanoma, non-Hodgkin lymphoma…
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma
- Trial name
- NCT01769222
- Testing
- Ipilimumab, Radiation therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Hepatocyte Receptor, Hepatocellular Carcinoma
Analysis of the Role of Hepatocyte SLAMF3 Receptor and Drug Resistance Proteins (MDR) in Resistance to Treatment With Sorafenib in CHC Patients
Primary liver cancer or hepatocellular carcinoma (HCC) is the 7th most common cancer in humans; 9th in women (figures from the Association for Research against Cancer ARC).
- Trial name
- SLAMF3 (NCT03113604)
- Testing
- Study on samples of tumor and peri-tumor tissues from patients with hepatocellular carcinoma
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hepatitis C, Hemophilia
Pegasys® Plus Ribavirin in Hemophilic Patients With Hepatitis C Virus Infection
Hemophilic patients are a known high risk groups for acquiring the hepatitis C. The surveillance data from Ministry Of Health in IR.Iran had shown that 60% of them are infected with HCV infection.
- Trial name
- NCT00707772
- Testing
- PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
- Where
- Iran
- Volunteers
- 400 people
- Sponsor
- Baqiyatallah Medical Sciences University