Clinical trials: Protein Digestion
Stomach Neoplasms
Density of Neurons in the Stomach and Prognosis of Gastric Adenocarcinoma
Preclinical studies at our institution, based on a genetic mouse model of stomach cancer, strongly suggest that innervation of the stomach wall is deeply involved in tumorigenesis of stomach cancer.
- Trial name
- NCT01821196
- Testing
- biopsy
- Sponsor
- St. Olavs Hospital
Aging, Appetite Loss
Effect of a Novel Protein Supplement on Appetite in Older Adults
An acute randomized crossover trial comparing the effects of the whey hydrolysate, whey protein concentrate and placebo (still flavored water) on appetite and energy intake in older adults.
- Trial name
- NCT05871060
- Testing
- Whey Protein Concentrate, Whey hydrolysate
- Where
- Ireland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Advanced Cancer, Ovarian Cancer
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced…
- Conditions
- Advanced Cancer, Ovarian Cancer, Lung Cancer, Colon Cancer
- Trial name
- NCT04354246
- Testing
- Dose escalation: COM902 monotherapy., Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE), Cohort expansion: COM902 (RDFE) monotherapy.
- Where
- 9 sites in United States
- Volunteers
- 94 people
- Sponsor
- Compugen Ltd
Breast Cancer, Multiple Myeloma
Standard Care Alone or With Acupuncture for CIPN in Breast Cancer and Multiple Myeloma
The purpose of this study is to determine whether the addition of acupuncture to standard treatment reduces the level of chemotherapy induced peripheral neuropathy experienced by patients with breast cancer, multiple myeloma…
- Conditions
- Breast Cancer, Multiple Myeloma, Gastrointestinal Cancer, Gynaecological Cancer
- Trial name
- ACUFOCIN (NCT02275403)
- Testing
- Acupuncture, Medication taken to manage the symptom burden of CIPN
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- The Christie NHS Foundation Trust
Gut Epithelial Permeability, Gut Microbiota Composition and Diversity
Impact of Dairy Integration Into Canadian Food Guide on Gut Health
The primary objective is to investigate the impact of milk, fermented milk, and soy beverages, incorporated in a diet reflecting adherence to Canadian food guide recommendations on food choices on gut microbiota in middle-aged…
- Conditions
- Gut Epithelial Permeability, Gut Microbiota Composition and Diversity, Gut and Circulating Inflammatory Markers, Milk and Digestion
- Trial name
- GutMilk (NCT07257913)
- Testing
- Milk, Fermented milk, Soy beverage
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Hepatitis C, Chronic
Phase I-II Vaccination of Autologous Dendritic Cells Transduced With Adenoviral Vector Encoding NS3 in Hepatitis C Encoding NS3 in Hepatitis C
Dendritic cells (DC) play a central role in the activation of T-cell responses and have shown to be very immunogenic in preclinical in vivo and in vitro assays.
- Trial name
- NCT02309086
- Testing
- Autologous dendritic cells transduced with Ad encoding NS3
- Volunteers
- 5 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Hepatitis C, Chronic
A Study of Albuferon and Ribavirin in Interferon Naive Subjects With Chronic Hepatitis C Genotype 1
The purpose of the study is to evaluate the efficacy and safety of Albuferon in combination with ribavirin in interferon (IFN) alfa treatment-naïve subjects with chronic hepatitis C genotype 1.
- Trial name
- NCT00115908
- Testing
- Albuferon, Ribavirin, PEG-IFNalfa2a
- Where
- 87 sites in Australia, Canada and 6 more
- Volunteers
- 458 people
- Sponsor
- Human Genome Sciences Inc.
Gastric Carcinoma
Immunotherapy of Gastric Cancer With Autologous Tumor Derived Heat Shock Protein gp96
The purpose of this study is to evaluate the safety and effectiveness of autologous gp96 treatment of gastric cancer.
- Trial name
- NCT02317471
- Testing
- autologous gp96 vaccination, Oxaliplatin+S-1
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Chinese PLA General Hospital
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Liver Cirrhosis
Safety and Tolerability Study of OP-724 in Liver Cirrhosis Patients by HIV/HCV with Hemophilia.
To evaluate the safety and tolerability of OP-724 in liver cirrhosis patients caused by HIV/HCV co-infection with hemophilia.
- Trial name
- NCT04688034
- Testing
- OP-724
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Kiminori Kimura, MD
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Advanced Cancer, Metastatic Cancer
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
This clinical trial is evaluating a drug called ART0380 in participants with advanced or metastatic solid tumors. The main goals of this study are to: Find the recommended dose of ART0380 that can be given safely to participants…
- Conditions
- Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer
- Trial name
- NCT04657068
- Testing
- ART0380, Gemcitabine, Irinotecan
- Where
- 88 sites in United States, France and 2 more
- Volunteers
- 542 people
- Sponsor
- Artios Pharma Ltd
Obesity and Other Hyperalimentation
Digestion of Foods Consumed in Africa
As populations become urbanized in Africa, the change to a more Westernized diet has been associated with rise in obesity and related metabolic syndrome diseases.
- Trial name
- NCT03007368
- Testing
- Rice, Potato, Pasta
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Crohn's Disease
Study to Evaluate the Safety and Efficacy of Adalimumab in Chinese Subjects With Moderate to Severe Crohn's Disease
This study will evaluate the efficacy and safety of adalimumab induction and maintenance treatment in subjects with moderately to severely active Crohn's disease in China.
- Trial name
- NCT02499783
- Testing
- adalimumab
- Volunteers
- 205 people
- Sponsor
- AbbVie
Lung Cancer (Locally Advanced or Metastatic), Pancreas Cancer, Metastatic
Molecular Imaging of Fibroblast Activation Protein Expression Using Labeled Technetium-99m HYNIC-FAPI
The study should evaluate the biological distribution of 99mTc-HYNIC-FAPI in metastatic cancer patients.
- Conditions
- Lung Cancer (Locally Advanced or Metastatic), Pancreas Cancer, Metastatic, Breast Cancer (Locally Advanced or Metastatic), Colorectal Cancer (Locally Advanced or Metastatic)
- Trial name
- NCT07457541
- Testing
- [99mTc]Tc-HYNIC-FAPI
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Knee Osteoarthritis, Chondropathy
Adipose-derived MSCs After Enzymatic Digestion vs. Mechanically Fragmented Fat Transfer in Knee Osteoarthritis Treatment
The aim of the study is to compare the clinical effects of treatment of knee osteoarthritis using adipose tissue mesenchymal stromal cells obtained by an enzymatic method with the outcomes of the therapy with the mechanically…
- Trial name
- NCT04675359
- Testing
- Autologous adipose derived Mesenchymal Stromal Cells (MSC) injection into the knee joint
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Gynecologic Surgical Procedures, Postoperative Nausea and Vomiting (PONV)
Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery
The aim of this clinical trial is to evaluate the impact of the analgesic Oliceridine on postoperative nausea and vomiting (PONV) following gynecological laparoscopic surgery.
- Conditions
- Gynecologic Surgical Procedures, Postoperative Nausea and Vomiting (PONV), Laparoscopy
- Trial name
- NCT07026162
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 96 people
- Sponsor
- YanYing Xiao
Main Focus: Gluten and Starch Digestibility
Digestion of Gluten in the Presence of Enzymes
This study evaluates the impact of two dietary supplements (Elevase® and DE111®) and of oatmeal properties on the digestion of gluten and starch and on the glycemic response.
- Trial name
- GlutDigest (NCT04489810)
- Testing
- Elevase®, DE111®, Meal A
- Where
- Ireland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Inflammatory Bowel Disease, Crohn's Disease
Low-dose CT Using Iterative Reconstruction in Patients With Inflammatory Bowel Disease
The purpose of this study is to validate the use of a low-dose computed tomography (CT) protocol and facilitate reduced radiation doses in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01244386
- Where
- Ireland
- Volunteers
- 250 people
- Sponsor
- University College Cork
Digestive Health, Indigestion
Efficacy of a Digestive Enzyme Blend
The purpose of this study is to investigate the effect of a digestive enzyme supplement (three times per day for 30 days) on gastrointestinal distress (GID) and body composition (body mass and body fat percentage) in healthy men…
- Conditions
- Digestive Health, Indigestion, Protein Digestion, Carbohydrate Digestion
- Trial name
- MULO (NCT04917913)
- Testing
- Digestive enzyme blend
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes