Clinical trials: Protein Digestion
Extrahepatic Bile Duct Cancer, Pancreatic Cancer
Blood Proteins in Finding Pancreatic Cancer and Extrahepatic Biliary Tract Cancer
RATIONALE: Studying samples of blood in the laboratory from patients with cancer and from healthy participants may help doctors identify and learn more about proteins related to cancer.
- Trial name
- NCT00559598
- Testing
- proteomic profiling, medical chart review
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Energy Intake, Activities of Daily Living
Impact on Energy Intake by Implementing Recommended Food Texture Through Dietary Guidance
An intervention study on the effect of dietary guidance with focus on implementing recommended food texture, at the department of Eating and Swallowing difficulties, Region Midtjylland, Denmark.
- Conditions
- Energy Intake, Activities of Daily Living, Quality of Life, Protein Intake
- Trial name
- NCT04655547
- Testing
- Dietary guidance
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Pancreatic Cancer
Identification of Biomarkers for Early Detection of Pancreatic Cancer
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897494
- Testing
- protein expression analysis, laboratory biomarker analysis, mass spectrometry
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Crohn's Disease
To Evaluate SBI in the Dietary Management of Mild to Moderate Crohn's Disease
The objective of this study is to evaluate the nutritional therapy with SBI (a medical food) as compared to placebo in the clinical dietary management of mild to moderate Crohn's disease.
- Trial name
- NCT02649075
- Testing
- Serum-derived Bovine Immunoglobulin / Protein Isolate
- Where
- 7 sites in United States
- Volunteers
- 7 people
- Sponsor
- Entera Health, Inc
Cancer
OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer
RATIONALE: Studying protein expression in sentinel lymph node tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00900302
- Testing
- protein expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- OHSU Knight Cancer Institute
Gastric Carcinoma
Immunotherapy of Gastric Cancer With Autologous Tumor Derived Heat Shock Protein gp96
The purpose of this study is to evaluate the safety and effectiveness of autologous gp96 treatment of gastric cancer.
- Trial name
- NCT02317471
- Testing
- autologous gp96 vaccination, Oxaliplatin+S-1
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Chinese PLA General Hospital
Obesity
Starches Digestion After Obesity Surgery.
Despite an impressive capacity to induce diabetes remissions, the gastric bypass surgery has been associated with the onset of hyperglycemic peaks, which are very intensive and transient, in formally non diabetic patients.
- Trial name
- GLUBYPASS (NCT02789553)
- Testing
- First starch meal then meal with glucose syrup, First meal with glucose syrup then starch meal
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Prostate Cancer, Breast Cancer
An Open Label Phase I Study to Eval the Safety and Tolerability of a Vaccine (GI-6207) Consisting of Whole, Heat-killed Recombinant Saccharomyces Cerevisiae (Yeast) Genetically Modified to Express CEA Protein in Adults With Metastatic CEA-expressing ...
Objectives: To find out the maximum tolerated dose of the GI-6207 vaccine (the highest dose that does not cause unacceptable side effects), and to evaluate any side effects. To see if GI-6207 has any effect on patients tumors.
- Conditions
- Prostate Cancer, Breast Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- NCT00924092
- Testing
- GI-6207 [Recombinant Saccharomyces Cerevisia, (Yeast CEA Vaccine)(GI-6207[Recombinant Sarrcharomyces Cerevusua-CEA (610D)])
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Irritable Bowel Syndrome, Fructose Intolerance
Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance?
In this study we will investigate the expression of the fructose transport protein GLUT5 in the small intestine in patients with functional GI disoders and fructose intolerance compared to matched healthy controls.
- Trial name
- NCT01705171
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brain-Gut Research Group
Cancers With HER2 Expression
A First in Human Study of BAY2701439 to Look at Safety, How the Body Absorbs, Distributes and Excretes the Drug, and How Well the Drug Works in Participants With Advanced Cancer Expressing the HER2 Protein
In this study, researchers want to learn about the safety of drug BAY2701439 and how well the drug works in patients with advanced cancer that has the protein HER2 (Human Epidermal growth factor Receptor 2) and cannot be cured by…
- Trial name
- NCT04147819
- Testing
- BAY2701439
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Bayer
Gut Epithelial Permeability, Gut Microbiota Composition and Diversity
Impact of Dairy Integration Into Canadian Food Guide on Gut Health
The primary objective is to investigate the impact of milk, fermented milk, and soy beverages, incorporated in a diet reflecting adherence to Canadian food guide recommendations on food choices on gut microbiota in middle-aged…
- Conditions
- Gut Epithelial Permeability, Gut Microbiota Composition and Diversity, Gut and Circulating Inflammatory Markers, Milk and Digestion
- Trial name
- GutMilk (NCT07257913)
- Testing
- Milk, Fermented milk, Soy beverage
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Hepatic Cirrhosis
Evaluation of the PK of NRL972 Following Pre- and co-Administration of Ursodeoxycholic Acid and Cloxacillin
A study in healthy volunteers to determine whether different drugs metabolised by the liver have any effects on how NRL972 is processed within the body.
- Trial name
- NCT00857480
- Testing
- NRL972
- Where
- Bulgaria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norgine
Head and Neck Squamous Cell Carcinoma, Metastatic Pancreatic Adenocarcinoma
Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors
This pilot phase Ib trial studies the side effects and best dose of recombinant EphB4-HSA fusion protein when given together with standard chemotherapy regimens in treating patients with solid tumors that have spread to other…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Metastatic Pancreatic Adenocarcinoma, Non-Resectable Cholangiocarcinoma, Pancreatic Adenocarcinoma
- Trial name
- NCT02495896
- Testing
- Cisplatin, Docetaxel, Gemcitabine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Southern California
Crohn's Disease, IBD
Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)
Crohn's disease and ulcerative colitis affect about 1.6 to 3 million people in the United States with many of those being young children and adolescents.
- Trial name
- ENvISION (NCT04131504)
- Testing
- Infliximab, Adalimumab
- Where
- 4 sites in United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neoplasms, Cancer
Cancer Experience Registry (CER) for Cancer Patients and Caregivers
The Cancer Experience Registry®: An Online Survey Research Study to Understand the Experiences of Those Impacted By a Cancer Diagnosis. The Registry is a web-based platform to distribute cross-sectional and longitudinal surveys.
- Conditions
- Neoplasms, Cancer, Caregiver
- Trial name
- CER (NCT02333604)
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Cancer Support Community, Research and Training Institute, Philadelphia
Obesity, Gut Microbiota Modulation
ESAN III - Energy Sensing in Depression
The purpose of this study is to assess the effects of carotenoids from natural carrot juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Obesity, Gut Microbiota Modulation, Immunomodulation
- Trial name
- NCT06985381
- Testing
- Carotenoid-rich juice, Control
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Main Focus: Gluten and Starch Digestibility
GlutDigest - Pilot Study
This is a pilot, feasibility study to evaluate, test and optimize sample analysis procedures and protocols before the full-scale, crossover study is conducted.
- Trial name
- GlutDigestP (NCT04489836)
- Testing
- Glutalytic®, DE111®, Meal A
- Where
- Ireland
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Parkinsons Disease (PD), Constipation - Functional
Nutritional Intervention for Constipation Symptoms in Patients With Parkinson's Disease
The goal of this clinical trial is to evaluate whether a dietitian-guided nutritional intervention can improve constipation symptoms in people with Parkinson's disease (PD).
- Trial name
- NUTRI-GUT-PD (NCT07213856)
- Testing
- Dietitian-Guided Nutritional Intervention
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Multiple Myeloma, Myelodysplastic Syndromes
A Study of Special Use Results Surveillance of Revlimid 5mg Capsules
To understand the safety and efficacy of Revlimid® 5 mg Capsules (hereinafter referred to as Revlimid) in all patients who are treated with it under the actual condition of use pursuant to the conditions of approval. 1.
- Trial name
- NCT02921802
- Where
- Japan
- Volunteers
- 4,626 people
- Sponsor
- Celgene
Diet Habit, Gall Stone
Are There Dietary Factors Affecting the Development of Pancreatitis in Patients With Gallstones?
The most common cause of acute pancreatitis is gallstones. It is known that diet and obesity play a role in the formation of gallstones.
- Conditions
- Diet Habit, Gall Stone, Pancreatitis
- Trial name
- NCT05142657
- Testing
- diet survey
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Training and Research Hospital