Clinical trials: Protein Digestion
Liver Cancer, Pancreatic Adenocarcinoma
Immunotherapy of Tumor With Autologous Tumor Derived Heat Shock Protein gp96
To evaluate the safety and effectiveness of autologous gp96 treatment of liver cancer and Pancreatic Adenocarcinoma
- Trial name
- NCT02133079
- Testing
- autologous gp96 vaccination
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Cure&Sure Biotech Co., LTD
Milk Intolerance
Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyzed A1 Milk
The aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from…
- Trial name
- NCT05305391
- Testing
- Dietary intervention
- Where
- Finland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Turku
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly
Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity
- Trial name
- CARTIER (NCT03711110)
- Testing
- Intensive cardiovascular monitoring, No intervention
- Where
- 14 sites in Spain
- Volunteers
- 514 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Cancer, Cancer Metastatic
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors
The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors.
- Conditions
- Cancer, Cancer Metastatic, Neoplasms, Breast Cancer
- Trial name
- NCT05131815
- Testing
- Virtual group based physical activity (BurnAlong) and Social Media Discussion Board
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Chronic Hepatitis C Infection
Open-Labeled Study of PSI-7977 and RBV With and Without PEG-IFN in Treatment-Naïve Patients With HCV GT2 or GT3
This study is to assess the safety and tolerability of sofosbuvir (SOF) 400 mg with and without ribavirin (RBV) and/or with and without pegylated interferon alfa-2a (PEG) in subjects with genotype 1, 2 or 3 hepatitis C (HCV)…
- Trial name
- NCT01260350
- Testing
- SOF, RBV, PEG
- Where
- 2 sites in New Zealand
- Volunteers
- 292 people
- Sponsor
- Gilead Sciences
Hepatocellular Carcinoma
Toripalimab Plus Sorafenib in Patients With Advanced-Stage Hepatocellular Carcinoma
Toripalimab is a programmed cell death protein 1 antibody.This is an open-label, single arm, multi-center exploratory study.The objective of this study is to evaluate the efficacy and safety of therapy with toripalimab and…
- Trial name
- Toripalimab (NCT04926532)
- Testing
- Toripalimab, Sorafenib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Intestinal Barrier Function, Protein Digestion Kinetics
Health Effects of Sustainable Future Proteins
In the current study the investigators aim to assess the nutritional quality and bio-functional activity of two alternative protein sources bovine plasma and corn and from the benchmark protein whey.
- Trial name
- Su-Pro (NCT03744221)
- Testing
- Corn protein powder, Bovine plasma protein powder, Whey protein powder
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Cell-free fetal DNA (cffDNA) is present in the maternal blood from the early first trimester of gestation and makes up 5%-20% of the total circulating cell-free DNA (cfDNA) in maternal plasma.
- Conditions
- Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease, Cystic Fibrosis, Fragile X Syndrome
- Trial name
- DANNIgene (NCT06147414)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease
The purpose of this trial is to evaluate natalizumab in individuals with moderately to severely active Crohn's Disease.
- Trial name
- NCT00078611
- Testing
- natalizumab
- Where
- 75 sites in United States, Canada
- Volunteers
- 462 people
- Sponsor
- Biogen
The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake
Effects of Gum Chewing on Appetite and Digestion
One obvious property difference between energy-yielding beverages and solid foods is the oral mechanical processing required to prepare the two food forms for swallowing.
- Conditions
- The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake, It is Hypothesized That the Effects of Mastication Will be Less Evident in Obese Compared to Lean Individuals
- Trial name
- NCT01070212
- Testing
- soft gum, firm gum, no gum
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Purdue University
HER-2 Gene Amplification, HER2-positive Gastric Cancer
Safety and Activity Study of HER2-Targeted Dual Switch CAR-T Cells (BPX-603) in Subjects With HER2-Positive Solid Tumors
This is a Phase 1/2, open-label, multicenter, non-randomized study to investigate the safety, tolerability, and clinical activity of HER2-specific dual-switch CAR-T cells, BPX-603, administered with rimiducid to subjects with…
- Conditions
- HER-2 Gene Amplification, HER2-positive Gastric Cancer, HER2-positive Breast Cancer, HER-2 Protein Overexpression
- Trial name
- NCT04650451
- Testing
- chimeric antigen receptor (CAR) T cell therapy
- Where
- 7 sites in United States
- Volunteers
- 220 people
- Sponsor
- Bellicum Pharmaceuticals
Abdominal Pain, GI Disorders
Radicle GI Health 24: A Study of Health and Wellness Products on GI Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on GI health and related health outcomes
- Conditions
- Abdominal Pain, GI Disorders, Digestion
- Trial name
- NCT06376695
- Testing
- Radicle GI Health Active Study Product 1.1 Usage, Radicle GI Health Active Study Product 2.1 Usage
- Where
- United States
- Volunteers
- 4,607 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Pancreas Cancer
Evaluation of CEMIP in Pancreatic Cancer
Pancreatic cancer (PC) is one of the most lethal diseases among all cancer types. The diagnosis of PC is usually based on radiology or invasive endoscopic techniques. Various types of tumor markers are used for diagnosing PC.
- Trial name
- NCT03679910
- Testing
- CEMIP , CA19-9 ,CEA, A) CBC . B) RBG. C)KFT. D) LFT.
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gastrointestinal Stromal Tumor (GIST)
Five Year Adjuvant Imatinib Mesylate (Gleevec®) in Gastrointestinal Stromal Tumor (GIST)
This is a Phase II, non-randomized, open-label, multi-center study conducted in the USA. The purpose of this trial is to evaluate the use of long term adjuvant imatinib mesylate in patients at significant risk for recurrence…
- Trial name
- NCT00867113
- Testing
- imatinib mesylate
- Where
- 21 sites in United States
- Volunteers
- 91 people
- Sponsor
- Novartis Pharmaceuticals
Nutritional Deficiency, Ileostomy; Functional Disturbance
Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy
Clinical trial, active comparator, cross over, randomised. In total, 12 adults with an ileostomy will be randomised to a sequential 4 weeks intervention with different qualities and sources of protein wish 2-week washout periods.
- Conditions
- Nutritional Deficiency, Ileostomy; Functional Disturbance, Short Bowel Syndrome, Absorption; Disorder, Protein
- Trial name
- ABSOLYT (NCT04141826)
- Testing
- Hydrolysed whey, Intact whey, Caseinate
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Hvas
Clostridium Difficile
To Evaluate the Impact of SBI on C. Difficile in Hospitalized UC Patients
The effects of serum-derived bovine immunoglobulin/protein isolate (SBI) will be evaluated and compared to matching placebo in two distinct patient populations: I.
- Trial name
- NCT02730325
- Testing
- Serum-derived bovine immunoglobulin/protein isolate (SBI)
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Peritonitis, Sepsis
The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients
The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with…
- Conditions
- Peritonitis, Sepsis, Multiple Organ Failure, Death
- Trial name
- NCT01465711
- Testing
- All abdominal surgical procedures, Intubation, Imaging
- Where
- Germany
- Volunteers
- 137 people
- Sponsor
- University of Magdeburg
Anorexia, Cancer Cachexia
Open Label Study With OHR/AVR118 in Advanced Cancer Patients With Anorexia-Cachexia
The purpose of this study is to determine whether patients with advanced cancers who receive OHR/AVR118 solution for injection into the skin can achieve improvement in quality of life.
- Trial name
- NCT01206335
- Testing
- OHR/AVR118
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ohr Pharmaceutical Inc.
Protein Malabsorption
The Incorporation of Dietary Protein-Derived Amino Acids in Duodenal Epithelium
Rationale: Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion.This anabolic resistance may be related to decreased postprandial amino acid release in the circulation, due to greater amino…
- Trial name
- GutFeeding (NCT06091852)
- Testing
- Intrinsically labelled milk protein
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center