Clinical trials: Protein Metabolism
Diabetes Mellitus, Cardiovascular Diseases
Singapore Healthy Alternative Protein Evaluation Study
The overall aim of this randomized controlled trial is to investigate the effects of consuming a Plant-Based Meat alternative Diet (PBMD) compared to an Animal-Based Meat Diet (ABMD) on cardiometabolic health and protein…
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Protein Metabolism Disorder
- Trial name
- SHAPES (NCT05446753)
- Testing
- Animal-based meats, Plant-based meat alternatives
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Protein Metabolism
"Ounce-equivalents" in the Protein Foods Group: Benefits of Quality
The investigators will examine the effects of a given amount of a protein food source such as pork, mixed nuts, and tofu on anabolic response at the whole body and muscle levels in young, healthy adults.
- Trial name
- NCT03179462
- Testing
- Pork intake, Mixed nuts intake, Tofu intake
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Metabolism, Protein
(KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit
The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion from the beef in the elderly, leading to an…
- Trial name
- NCT04356573
- Testing
- Green Hayward Kiwifruit first, then Gold Kiwifruit, Gold Kiwifruit First, then Green Hayward Kiwifruit
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Protein Metabolism
Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides
Skeletal muscle quality is an important determinant of exercise performance and overall health. It is vital for not just movement, but also metabolizing nutrients.
- Trial name
- NCT03952884
- Testing
- Resistance Exercise, No Resistance Exercise, Leucine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Muscle Loss, Disuse Atrophy
Preventing Bed-rest Induced Muscle Loss in the Elderly
Episodes of inactivity due to hospitalisation, as short as 5 days, are associated with rapid muscle and strength loss in the elderly.
- Conditions
- Muscle Loss, Disuse Atrophy, Protein Metabolism, Prehabilitation
- Trial name
- NCT04422665
- Testing
- Resistance exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Glucose Homeostasis, Protein Metabolism
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Background: Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress.
- Conditions
- Glucose Homeostasis, Protein Metabolism, Lipid Metabolism, Respiratory Function
- Trial name
- NCT01143493
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Metabolism, Inborn Errors, Lipid Metabolism, Inborn Errors
Fat and Sugar Metabolism During Exercise in Patients With Metabolic Myopathy
This study aims to characterize the pathophysiological mechanisms of 21 different metabolic myopathies. The study will focus on exercise capacity and the metabolic derangement during exercise.
- Conditions
- Metabolism, Inborn Errors, Lipid Metabolism, Inborn Errors, Carbohydrate Metabolism, Inborn Errors, Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency
- Trial name
- NCT02635269
- Testing
- Sugar
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Muscle Protein Synthesis, Protein Metabolism
Time Course of Postprandial Protein Metabolism
The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults.
- Trial name
- NCT04121689
- Testing
- Milk Protein Concentrate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Protein Metabolism
Optimal Protein Dose Per Meal During Weight Loss in Perspective to Maintaining Muscle Mass
The primary aim of the trial is to determine the optimal dose of protein per meal in relation to enhancing muscle protein synthesis and thereby in perspective counteract muscle loss during weight loss.
- Trial name
- NCT03326284
- Testing
- 15 g protein hypocaloric, 35 g protein hypocaloric, 60 g protein hypocaloric
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Muscle Protein Synthesis, Endotoxemia
Whey vs Casein to Combat Post-inflammatory Protein and Muscle Waste in Acute Disease
This study compares three different protein supplements (casein, whey and leucine-enriched whey) and their effect on post-inflammatory muscle waste in a model of acute disease.
- Conditions
- Muscle Protein Synthesis, Endotoxemia, Nutrition, Milk Protein
- Trial name
- NCT03319550
- Testing
- Casein, Whey, Leucine-enriched whey
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Protein/Amino Acid Metabolism, Indicator Amino Acid Oxidation Method
Influence of Habitual Protein Intake on AA Tracer Oxidation
Protein is an essential nutrient that one's diet to maintain important bodily functions and to recover from exercise. Currently, the Indicator Amino Acid Oxidation method (IAAO) has been used to determine protein requirements in…
- Trial name
- HPI (NCT03845569)
- Testing
- Dietary protein intake reduction, Three day Controlled Diet
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dietary Fats, Carbohydrates
Macronutrients and Postprandial Vascular Function
Vascular function decreases following the intake of a mixed meal in some, but not all studies. Differences in the relative amounts of dietary fat, carbohydrates and protein present in the mixed-meal challenges may have…
- Conditions
- Dietary Fats, Carbohydrates, Proteins, Macronutrients
- Trial name
- NCT03139890
- Testing
- High-fat (HF-LC-LP) milkshake, High-carbohydrate (LF-HC-LP) milkshake, High-protein (LF-LC-HP) milkshake
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Protein Metabolism
Protein Ingestion Before Training Low
A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks.
- Trial name
- NCT03147001
- Testing
- Protein ingestion
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sarcopenic Obesity, Muscle Weakness
Mechanisms of Age-Related Muscle Loss
Two independent, but interrelated conditions that have a growing impact on healthy life expectancy and health care costs in developed nations are the age related loss of muscle mass (sarcopenia) and obesity.
- Conditions
- Sarcopenic Obesity, Muscle Weakness, Protein Metabolism Disorder, Physical Activity
- Trial name
- NCT03113279
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Crohn's Disease, Protein Metabolism
Protein and Energy Metabolism in Pediatric Crohn's Disease
The metabolic response to Crohn's disease, including increased proteolysis and lipolysis and changes in energy expenditure, plays a significant role in the resulting malnutrition from which these patients suffer.
- Conditions
- Crohn's Disease, Protein Metabolism, Energy Metabolism
- Trial name
- NCT00583232
- Testing
- Stable isotope infusions
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Bone Diseases, Metabolic, Acid-Base Imbalance
The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation
Mainly due to the absence of gravitational forces in weightlessness, astronauts suffer from an increased bone loss- negatively affecting health and vitality during a mission.
- Conditions
- Bone Diseases, Metabolic, Acid-Base Imbalance, Muscular Atrophy, Sprains and Strains
- Trial name
- NUC (NCT01509456)
- Testing
- Potassium Bicarbonate
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Crohn's Disease, Ulcerative Colitis
Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease, which includes both Crohn's disease and ulcerative colitis, is a disease of the gastrointestinal tract leading to symptoms of abdominal pain, diarrhea, and growth disturbance.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Protein Metabolism
- Trial name
- NCT00586352
- Testing
- stable isotope infusions
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Indiana University
Critical Illness, Protein Metabolism
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Introduction: Protein loss during critical illness is an important problem and is shown to predict overall survival. In animal studies, infusion of leucine is shown to increase the synthesis of muscle protein by 30-40% and…
- Conditions
- Critical Illness, Protein Metabolism, Pharmaconutrients
- Trial name
- NCT01461603
- Testing
- Vamin (Fresenius Kabi), 3hydroxybutyrate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Metabolism, Elderly
Citrulline and Protein Metabolism in the Malnourished Elderly People
The aim of this study is to evaluate the effects of a supplementation of citrulline for three weeks in elderly malnourished and hospitalised subjects on muscle protein synthesis.
- Trial name
- CIPROAGE (NCT00714675)
- Testing
- Citrulline, Amino acids
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Diseases, Metabolic, Acid-Base Imbalance
Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation
Randomized cross-over design with 10 male subjects and 3 campaigns to test whether the negative effects of bed rest (6º head-down tilt) on the various systems of the body and the consequences to health of simulated weightlessness…
- Conditions
- Bone Diseases, Metabolic, Acid-Base Imbalance, Muscular Atrophy, Sprains and Strains
- Trial name
- SAG (NCT01820702)
- Testing
- Defined Training Programme
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center