Clinical trials: Protein Metabolism Disorder
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Smoking, Overweight
The Effect of a High Protein Diet Versus a Low Fat Diet on Body Weight After Smoking Cessation
The purpose of this study is to determine whether subjects following a high protein diet will gain less in weight after smoking cessation compared to subjects following a low fat diet due to the effects of protein on metabolic…
- Conditions
- Smoking, Overweight, Obesity
- Trial name
- NCT01069458
- Testing
- The high protein diet group and the low fat diet group
- Where
- Norway
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Lack of Satiety, Dietary Modification
Breakfast Consumption in Preschoolers: Satiety, Diet Quality and Memory
One important factor determining school performance is the consumption of breakfast. While research has shown that older children perform better in school after consuming breakfast, there are little data for preschool-age…
- Conditions
- Lack of Satiety, Dietary Modification, Memory Deficits, Obesity
- Trial name
- NCT02122224
- Testing
- High fiber breakfast, High Protein Breakfast, High Protein/High Fiber Breakfast
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Purdue University
Protein Malabsorption, Nutritional Deficiency
Bioavailability of Proteins From Plant Based Diets
Proteins play an important role as structural and functional components for the human body and prevent stunting. Protein quality has a great importance in meeting the nutritional needs of populations across the world throughout…
- Conditions
- Protein Malabsorption, Nutritional Deficiency, Nutritional Stunting
- Trial name
- NCT04866927
- Testing
- Use of stable isotopic dilution to assess protein digestibility from Faba bean and to evaluate amino acid bioavailability
- Where
- Morocco
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- International Atomic Energy Agency
Metabolic Diseases
The Metabolic Effects of Consuming Carbohydrate With Different Protein Types
This study aims to find out how consuming different proteins with rice affect metabolism. Most meals the investigators eat predominantly consist of a carbohydrate and protein (i.e. rice, noodles, bread etc with meats or seafood).
- Trial name
- NCT02380846
- Testing
- White rice, Rice with chicken breast, Rice with fish
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Mevalonate Kinase Deficiency
Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency
Mevalonate kinase deficiency (HyperIgD syndrome, HIDS) is an inborn error of immunity caused by a block in the mevalonate pathway.
- Trial name
- NCT06497829
- Testing
- geranylgeraniol
- Where
- Czechia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Motol
Type 2 Diabetes
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.
The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.
- Trial name
- NCT01043445
- Testing
- GPR 119 agonist, 2-oleyl glycerol, Oleic acid, Vehicle
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Sarcopenia
Effect of an EAA/Whey Composition on Protein Metabolism
Sarcopenia, a progressive loss of muscle mass, strength and function, is an inevitable natural process of aging. While it may be impossible to completely reverse the progress of sarcopenia, it is well established that intake of…
- Trial name
- NCT03502941
- Testing
- 6.3 g of EAAs mixture and whey protein isolate, 12.6 g of EAAs mixture and whey protein isolate, 12.6 g of whey protein isolate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Liver Disease, Hyponatremia
Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Liver Function
A study to compare a 48-hour continuous infusion of conivaptan in subjects with mild and moderate liver impairment versus subjects with normal liver function
- Trial name
- NCT00851227
- Testing
- conivaptan hydrochloride
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cumberland Pharmaceuticals
Alzheimer's Disease (AD), Neurodegenerative Disease
A Biomarker-chip Assay in Preserved Red Blood Cells for the Diagnosis of Alzheimer's Disease
The ADCHIP study (ST0067) is a non-interventional, monocentric, prospective study conducted by Amoneta Diagnostics and the Leenaards Memory Center (Lausanne, Switzerland).
- Conditions
- Alzheimer's Disease (AD), Neurodegenerative Disease, Dementia, Frontotemporal Dementia (FTD)
- Trial name
- ADCHIP (NCT07307872)
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Muscle Wasting, Protein Intake
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat…
- Conditions
- Muscle Wasting, Protein Intake, Ketosis, Caloric Restriction
- Trial name
- NCT04744142
- Testing
- Ketone supplementation, Increased protein intake
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Sarcopenic Obesity, Frailty
Multicomponent Analysis of phYsical Frailty BiomarkErs: Focus on Mitochondrial Health - MAYBE
The study will be conducted in a group of obese sarcopenic patients (Sarco-Ob) aged > 60 years on moderately hypocaloric diet therapy aimed at comparing the effect of a strength exercise protocol, combined or not with dietary…
- Conditions
- Sarcopenic Obesity, Frailty, Malnutrition; Protein
- Trial name
- MAYBE (NCT05938205)
- Testing
- AA-1, AA-2, Exe-H
- Where
- Italy
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Phenylketonurias
Amino Acid Kinetics of GMP-AA in Healthy Human Volunteers
Children with phenylketonuria (PKU) are treated with a special diet supplemented with a synthetic protein based on amino acids. These have a poor taste and are inefficiently used by the body.
- Trial name
- NCT05971563
- Testing
- Casein, L-amino acids, CGMP-AA
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Marasmus, Kwashiorkor
Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers
PRIMARY OBJECTIVE : To determine whether mothers, given minimal group training, are capable of using a MUAC (mid-upper arm circumference) bracelet to screen their children for malnutrition and categorise them into one of three…
- Conditions
- Marasmus, Kwashiorkor, Malnutrition; Degree, Moderate, Malnutrition
- Trial name
- MUAC (NCT01790815)
- Where
- Niger
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Overweight, Obesity
Role of Dietary Protein on Satiety, Food Intake and Thermic Effect of Food
Objectives: To determine the effect of protein content of familiar breakfast meals on subjective appetite, food intake (FI), glycemic response and Thermic Effect of Food (TEF) in normal weight (NW) and overweight (OW)/obese (OB)…
- Trial name
- NCT02200796
- Testing
- Control Meal, Low Protein Meal, Moderate Protein Meal
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Vitamin D Deficiency
Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children
The purpose of this study is to determine if the vitamin D binding protein genotype influences circulating vitamin D levels and if it may have functional consequences on vitamin D activity.
- Trial name
- VitaD (NCT01050387)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Yale University
Sarcopenia, Skeletal Muscle Atrophy
Plant Protein Blend and Milk Protein Supplements in Older Individuals
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Protein Malnutrition
- Trial name
- Blend-D2O (NCT06403137)
- Testing
- Resistance exercise, Standardized diet, Plant protein supplement
- Where
- Netherlands
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight, Obesity
Effects of WB-EMS and Protein Supplementation on LBM Maintenance During Intended Weight Loss
The present study aimed to determine the effect of different interventions on lean body mass maintenance under weight loss conditions in overweight and obese premenopausal women.
- Conditions
- Overweight, Obesity, Abdominal Obesity
- Trial name
- NCT03746977
- Testing
- Protein, Walking, WB-EMS application
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Sarcopenia
Study of Inactivity on Metabolism of Elderly Muscles
Skeletal muscle mass declines with inactivity (casting is a good example) and increases with activity (such as weightlifting). Whether muscle mass increases or decreases, is determined by whether more new proteins within muscle…
- Trial name
- NCT01818609
- Testing
- Step reduction
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes, Appetite Regulation
GLycaemic Outcomes With Whey Protein in ageING
The goal of this placebo-controlled, partial crossover design study is to identify the impact of consuming whey protein before meals on free-living glucose control in older adults living with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Appetite Regulation, Whey Protein, Ageing and Geriatric Health
- Trial name
- GLOWING (NCT07285811)
- Testing
- Glycaemic control with whey protein, Glycaemic control with different doses of whey protein
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Birmingham