Clinical trials: Protein Metabolism Disorder
Malnutrition
Translating Adoption of Improved Varieties Into Nutritional Impact
The purposes of this study are (1) to determine whether child nutrition-focused adoption encouragement messages focused on Quality Protein Maize (QPM) and the availability of small quantities of QPM seed can be effective at…
- Trial name
- QPM (NCT02710760)
- Testing
- Adoption Encouragement Treatment, Consumption Encouragement Treatment
- Volunteers
- 978 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Type 2 Diabetes
"Effect of High Fat and High Glycemic Diets
The investigators will determine whether people with high muscle mitochondrial capacity produce higher amount of reactive oxygen species (ROS) on consuming high fat /high glycemic diet and thus exhibit elevated cellular oxidative…
- Trial name
- NCT01494935
- Testing
- High Glycemic Diet, Control diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight, Obesity
Effects of WB-EMS and Protein Supplementation on LBM Maintenance During Intended Weight Loss
The present study aimed to determine the effect of different interventions on lean body mass maintenance under weight loss conditions in overweight and obese premenopausal women.
- Conditions
- Overweight, Obesity, Abdominal Obesity
- Trial name
- NCT03746977
- Testing
- Protein, Walking, WB-EMS application
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
PreDiabetes
Black Bean (Phaseolus Vulgaris L.) Protein Hydrolysates Reduce Acute Postprandial Glucose Levels
This work aimed to evaluate the acute effect of a black bean protein hydrolysate (BPH) on glucose levels in adults with normal glucose tolerance (NGT) and prediabetes.
- Trial name
- NCT05869344
- Testing
- Black bean protein hydrolysates (BPH), Commercial non-caloric beverage
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Claudia Luévano-Contreras
Metabolic Syndrome, Obesity
Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
Phase 1 of this study involves determining how consumption of dairy fat fractions rich in milk fat globule membrane influences postprandial inflammation in participants with metabolic syndrome or obesity during a high dietary fat…
- Trial name
- NCT01811329
- Testing
- Dairy fat, Dairy fat + MFGM, Palm fat
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Sleep, Body Composition
Nutrition, Body Composition, and Sleep
The purpose of the research is to determine if protein and omega-3 fatty acid supplementation improve sleep, improve body composition, and improve markers of metabolic health in postmenopausal women.
- Conditions
- Sleep, Body Composition, Strength, Insulin Sensitivity
- Trial name
- SHAPE (NCT03603041)
- Testing
- Whey protein, Omega-3 fatty acids
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Obesity
Effect of a Drinkable Yogurt Enriched in Proteins and Fibers on Satiety
Worldwide, obesity rate has increased so much in the latest years, that we call it obesity epidemic. Overweight could result of an unbalanced energetic balance for years.
- Trial name
- JIVAGO (NCT01304004)
- Testing
- Satiety
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
Osteoporosis, Sarcopenia
Does Potassium Bicarbonate Improve the Effect of Dietary Protein on Bone and Muscle?
The purpose of this study is to examine whether adding the basic salt potassium bicarbonate to the diet will have a positive effect on how dietary protein affects your bone and muscle.
- Trial name
- NCT00730184
- Testing
- potassium bicarbonate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Tufts University
Environmental Enteric Dysfunction (EED), Malnutrition
The Maternal EED Study
Undernutrition among women of reproductive age is more common in South Asia than in any other region. In South Asia, the prevalence of maternal undernutrition varies between 10 and 40%.
- Conditions
- Environmental Enteric Dysfunction (EED), Malnutrition, Women of Reproductive Age, Gut Microbiota
- Trial name
- NCT05862363
- Testing
- Microbiota-directed balanced energy protein (MD-BEP), Ready-to-use supplementary food-balanced energy protein (RUSF-BEP), Esophagogastroduodenoscopy (EGD)
- Where
- Bangladesh
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Obesity, Overweight
Energy Expenditure, Sleep and Macronutrients
The purpose of this study is to determine energy expenditure and sleep in response to protein/carbohydrate and fat ratio of the diet over a short-term and long-term period of time.
- Conditions
- Obesity, Overweight, Overnutrition, Nutrition Disorders
- Trial name
- NCT01551238
- Testing
- Differences in protein content of meals
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS)
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
Neurodegenerative disorders (NDDs), such as Parkinson¿s disease (PD), Alzheimer¿s disease (AD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are characterized by aggregation and intracellular accumulation…
- Conditions
- Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Alzheimer's Disease (AD)
- Trial name
- NCT06803784
- Testing
- Genetic: whole genome sequencing, whole exome sequencing
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Malnutrition; Diabetes, Malnutrition; Protein
Impact of Pea, Lentil and Oat Flour Particle Size on Glycemic Response in Healthy Adults
The study looks at the comparative effects of food products made with pea, lentil, and oat flour of various particle sizes on postprandial glycemic response, appetite and food intake, and amino acid release in healthy adults.
- Conditions
- Malnutrition; Diabetes, Malnutrition; Protein, Obesity
- Trial name
- PLO (NCT05291351)
- Testing
- Crackers made with whole, coarse, or fine pea and/or wheat flour, Crackers made with whole, coarse, or fine lentil and/or wheat flour, Porridge made with oat flour
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Gestational Diabetes
Soy Supplementation and Gestational Diabetes
The purpose of this study is to assess the feasibility of randomizing pregnant women at high risk for gestational diabetes to a 24-week period of soy food consumption.
- Trial name
- NCT02806739
- Testing
- Soy Group (Soy Protein + Isoflavones), Control Group (Minimize Soy Intake)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Orthopedic, Osteo Arthritis Knee
Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes
The proposed project is novel in its goal to establish a foundation for evidence-based rehabilitative nutrition guidelines to enhance perioperative patient care and improve post-operative rehabilitative outcomes specific to…
- Conditions
- Orthopedic, Osteo Arthritis Knee, Hip Osteoarthritis, Protein-Energy Malnutrition
- Trial name
- ESPI-PRO (NCT06734845)
- Testing
- Total Knee Arthroplasty, Total Joint Arthroplasty
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Polycystic Ovarian Syndrome (PCOS), Insulin Resistance
Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation
A goal of this study is to use a novel methodology to determine whether insulin resistance in women with polycystic ovary syndrome (PCOS) is related to the accumulation of proteins with modifications.
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Insulin Resistance, Overweight, Obese
- Trial name
- NCT02105428
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anemia, Vitamin D Deficiency
Evaluate the Change in Iron, Vitamin D, and C-Reactive Protein Level (CRP) in a 12 to 24 Week Period
The purpose of this study is to observe changes in iron status and vitamin D status during a 12-24 week supervised training program, specifically males and females between the ages of 30 and 50 years old.
- Trial name
- NCT01328704
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Avera McKennan Hospital & University Health Center
Obesity
High Quality Protein for Assisting With Weight Loss
The purpose of this study is to determine if, in presence of a reduced calorie diet, a breakfast containing high quality protein source (eggs) would be more effective in reducing hunger and increasing feeling of fullness compared…
- Trial name
- Egg_breakfast (NCT03085511)
- Testing
- Egg breakfast (EB), Weight Loss Counseling, Weight Loss Diet
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Glucose Homeostasis, Protein Metabolism
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Background: Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress.
- Conditions
- Glucose Homeostasis, Protein Metabolism, Lipid Metabolism, Respiratory Function
- Trial name
- NCT01143493
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Body Composition, Beneficial, Paresis
Meal Patterning on Weight Loss With Changes to Body Comp, Muscle and Metabolic Health
About two-thirds of adults in the United States are overweight or obese with likely adverse health consequences. A Moderate weight loss by dieting and exercise is recommended to improve health.
- Conditions
- Body Composition, Beneficial, Paresis, Impaired Glucose Tolerance
- Trial name
- S38 (NCT02066948)
- Testing
- wt loss, Meal Pattern, even
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Purdue University
Type 2 Diabetes
Expression of G-protein Coupled Receptor 120 Receptor in Adipose Tissue of German Diabetes Center Cohort Subjects
G-protein coupled receptor 120 (GPR120) is a G-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids.
- Trial name
- GPR120 (NCT03285750)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center