Clinical trials: Protein Restriction
Anorexia Nervosa, Anorexia Nervosa Restricting Type
Novel Targetable BIOmarkers in ANorexia NervosA
The overall aim of this present study is to evaluate Growth Differentiation Factor-15 (GDF-15) and inflammatory cytokines as a possible novel and readily treatable target for the successful therapy of Anorexia Nervosa (AN).
- Trial name
- BIOANNA (NCT05885724)
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Disease
Observational Study on CKD Treatment With a Ketosteril Supplemented Protein-restricted Diet (Keto-024-CNI)
The purpose of this study is to characterize the patient and disease profile under the influence of a protein-restricted diet supplemented with keto acids/amino acids (KA/AA), focusing on the progression of chronic renal…
- Trial name
- NCT02756520
- Testing
- Observational study: Supplemented protein-restricted diet
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Fresenius Kabi
Muscle Wasting, Protein Intake
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat…
- Conditions
- Muscle Wasting, Protein Intake, Ketosis, Caloric Restriction
- Trial name
- NCT04744142
- Testing
- Ketone supplementation, Increased protein intake
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cow's Milk Protein Allergy
Dietary Restriction Efficiency Assessment in CMPA
This clinical trial aims to evaluate and compare the efficacy of amino acid formula (AAF) and extensively hydrolyzed formula (eHF) in relieving symptoms in infants suspected of cow's milk protein allergy (CMPA) during the…
- Trial name
- NCT07199023
- Testing
- Amino Acid Formula (AAF), Extensively Hydrolyzed Formula (eHF)
- Volunteers
- 360 people
- Sponsor
- Ruijin Hospital
Overweight, Obesity
Effects of WB-EMS and Protein Supplementation on LBM Maintenance During Intended Weight Loss
The present study aimed to determine the effect of different interventions on lean body mass maintenance under weight loss conditions in overweight and obese premenopausal women.
- Conditions
- Overweight, Obesity, Abdominal Obesity
- Trial name
- NCT03746977
- Testing
- Protein, Walking, WB-EMS application
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Renal Insufficiency, Chronic
Effects of Low Protein Diet in Preventing the Progression of Chronic Kidney Disease(CKD)---a Prospective Study
The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 2 to 5).
- Trial name
- NCT02886975
- Testing
- low protein diet plus α-keto acid
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Renal Function Disorder
Renal Protective Effects of Restricted Protein Dietary With α-keto Acid in CAPD Patients
The prospective, double blind randomized, parallel control, and multi-center clinical trial will evaluate the safety and efficacy of α-keto acid with restricted protein diet on protecting residual renal function in continuous…
- Trial name
- NCT01255020
- Testing
- α-Keto Acid with restricted protein diet
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-sen University
Psychological Characteristics Involved in Dietary Compliance
Psychological Aspects and Patients Compliance to Restricted-protein Regimens in Chronic Kidney Disease
Dietary management of CKD patients proved important to postpone dialysis. Long-term compliance to protein-restricted diets was discussed. Psychological aspects involved in certain dietary behaviour have never been studied.
- Trial name
- KetoPsy (NCT02345759)
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Anemia Working Group Romania
Hemophilia
Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia
In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles.
- Trial name
- NCT07259356
- Testing
- Control, BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bonn
Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in…
- Conditions
- Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3, CKD Stage 4, CKD Stage 5
- Trial name
- PLAFOND (NCT05514184)
- Testing
- PLAFOND diet
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Frailty, Sarcopenia
Resistance-Based Multicomponent Training Plus Nutrition Supplementation for Intrinsic Capacity and Disability Risk in Chinese Rural Older Adults
This study is a five-arm, parallel-group, assessor-blinded randomized controlled trial designed to evaluate the effects of resistance-dominant multicomponent training combined with nutritional supplementation on intrinsic…
- Conditions
- Frailty, Sarcopenia, Mobility Limitation, Nutritional Risk
- Trial name
- NCT07660653
- Testing
- Routine Health Education, Leucine-Enriched Whey Protein and Vitamin D Supplementation, Progressive Resistance Training
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Capital University of Physical Education and Sports, China
Obesity
Study to Assess the Effects of High Protein Diet in Obesity, the LOWER Study
This program is carried out in a dedicated outpatient-clinic in the city of Hengelo for the evaluation and treatment of subjects with obesity.
- Trial name
- LOWER (NCT00862953)
- Testing
- Normal protein energy-restricted, High protein energy-restricted
- Where
- Netherlands
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Osteoarthritis
The Impact of Dietary Restriction of Animal Protein and Fat on Osteoarthritis
Patients will be randomized into the control or intervention group. Based on patient preference, the intervention group will be trained for one hour in either individual or group format on vegan diet.
- Trial name
- NCT01939262
- Testing
- Limitation of Animal Fat and Protein in the Diet, Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essentia Health
Pregnancy Related
Effects of Snakehead Fish on IUGR and LBW Among Second and Third Trimester Women
This study uses a Randomized Controlled Trial (RCT) design, conducted on pregnant women in Yogyakarta Province, Indonesia. This study aims to observe the effects of snakehead fish prepared-meal intervention on fetal growth…
- Trial name
- NCT07005609
- Testing
- Snakehead fish meal
- Where
- Indonesia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Cardiotoxicity, Breast Cancer
Dietary Restriction to Prevent Cardiotoxicity in Breast Cancer Patients
The goal of this clinical trial is to compare a dietary intervention with a regular diet in patients with early breast cancer undergoing anthracycline based chemotherapy.
- Trial name
- PROTECT-COR (NCT06622954)
- Testing
- Protein- and Calorie restriction
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Erasmus Medical Center
Stage 4 Chronic Kidney Disease
Supplemented Low Protein Diet and Progression of CKD
Investigators intend to analyze diets restricted in protein and supplemented with ketoanalogues of essential amino acids, to slow the progress of renal damage and improve nutritional status in diabetic patients over 60 years with…
- Trial name
- NCT03818568
- Testing
- ketoanalogues of essential amino acids
- Where
- 2 sites in Mexico
- Volunteers
- 149 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Obesity
Effects of Short-term Energy Deficit on Muscle Protein Turnover
Weight loss through energy restriction results in the loss of both fat and muscle mass. Muscle mass is important for mobility, strength, glucose control and energy expenditure, and therefore the retention of muscle mass during…
- Trial name
- NCT02406040
- Testing
- Energy Restriction
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
HIV-1
Inhibiting the Anti-apoptotic Factor, BCL-2, at the Time of ART Initiation to Promote Apoptosis of HIV-infected Cells and Restrict the Seeding of the HIV Reservoir (The INITIATE Study)
Combination therapy with antiretroviral medication (ART) has proven effective in keeping HIV suppressed and restoring the immune system, but it cannot cure the infection. Therefore, lifelong treatment is necessary.
- Trial name
- INITIATE (NCT07481175)
- Testing
- Venetoclax
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 38 people
- Sponsor
- Thomas Aagaard Rasmussen
Mobility Limitation
Effect of Whey Protein Supplementation and Resistance Exercise on Muscle Parameters in Older Adults
This research study is looking at the effects of a whey protein nutritional supplement on changes in muscle mass, strength and physical function in response to a 6 month program of strength training exercise.
- Trial name
- NCT00635739
- Testing
- Whey protein
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tufts University
Relapsed/Refractory Multiple Myeloma
Autologous Chimeric Antigen Receptor (CAR) T-cells Targeting the Kappa Myeloma Antigen (KMA) in Kappa Restricted Multiple Myeloma Patients With Relapsed/Refractory Disease
The study proposed here intends to evaluate the safety and efficacy of escalating doses of autologous PMCC-COE-KMA CAR T-cells administered to patients with relapsed/refractory multiple myeloma that expresses the KMA.
- Trial name
- KOALA (NCT07541391)
- Testing
- PMCC-COE-KMA
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia