Clinical trials: Proton Pump Inhibitor
Proton Pump Inhibitors, Gastroesophageal Reflux Disease
Should I Continue Taking My Acid Reflux Medication? Development and Pilot Testing of a Patient Decision Aid
BACKGROUND: Proton pump inhibitors (PPIs) treat problems such as gastroesophageal reflux disease (GERD). In many patients with mild or moderate GERD, PPIs should be used for 1-2 months but are often continued longer…
- Trial name
- NCT02558049
- Testing
- Decision aid
- Where
- 3 sites in Canada
- Volunteers
- 12 people
- Sponsor
- University of Ottawa
Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR)
Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) Patients
In this research study the investigators want to learn more about the effectiveness of an endoscopic procedure (an endoscope is a lighted tube that is placed down the participants esophagus, through the participants mouth) which…
- Conditions
- Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR), Reflux Disease, Gastro-Esophageal, Motility Disorder
- Trial name
- TIF-LPR (NCT05579587)
- Testing
- Transoral Incisionless Fundoplication
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Gastroesophageal Reflux Disease (GERD), Neurology
Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease
According to the statistics of the National Health Insurance Administration Ministry of Health and Welfare, the number of patients about gastroesophageal reflux disease (GERD) has increased from 610,000 to over 760,000 in the…
- Trial name
- NCT04660019
- Testing
- Scalp and auricular acupuncture, Seed acupressure
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Taipei Medical University WanFang Hospital
Liver Cirrhosis
Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial
Proton-pump inhibitors (PPI) are commonly prescribed in an uncritical manner to patients with liver cirrhosis without a clear evidence-based indication.
- Trial name
- STOPPIT (NCT04448028)
- Testing
- Esomeprazole 20mg
- Where
- Germany
- Volunteers
- 476 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
GERD
CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing
Background/Aim: To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P (CYP) 2C19 polymorphism in a population…
- Trial name
- NCT00354757
- Testing
- rabeprazole
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Esophageal Variceal Rebleeding
Prevention of Esophageal Variceal Rebleeding
BACKGROUND: Previous studies showed that the combination of endoscopic therapy with vasoconstrictor is better than either vasoconstrictor or endoscopic therapy alone in achieving the successful hemostatsis of acute variceal…
- Trial name
- NCT00863837
- Testing
- terlipressin (vasoconstrictor), pantoloc (proton pump inhibitor)
- Volunteers
- 120 people
- Sponsor
- National Science and Technology Council, Taiwan
Gastroesophageal Reflux, Heartburn
A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD)
The purpose of this study is to assess the efficacy and safety of long-term, "on-demand" maintenance therapy with rabeprazole in patients with non-erosive reflux disease (NERD).
- Trial name
- NCT00236392
- Testing
- rabeprazole
- Volunteers
- 422 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Gastroesophageal Reflux Disease (GERD)
Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
The objective of this study is to evaluate the safety and efficacy of IW-3718 administered to patients with GERD who continue to have persistent symptoms, such as heartburn and regurgitation, while receiving once-daily (QD)…
- Trial name
- NCT03561883
- Testing
- IW-3718, Standard-dose PPIs QD
- Where
- 101 sites in United States, Canada
- Volunteers
- 609 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Functional Dyspepsia, Epigastric Pain Syndrome
Lansoprazole Versus Mosapride for Functional Dyspepsia
Functional dyspepsia is a common symptom complex with significant impact on quality of life. There is no standard treatment for functional dyspepsia but therapeutic efficacy of proton pump inhibitor (PPI) and prokinetic agent…
- Conditions
- Functional Dyspepsia, Epigastric Pain Syndrome, Post Prandial Distress Syndrome
- Trial name
- NCT00663897
- Testing
- lansoprazole, mosapride
- Where
- Taiwan
- Volunteers
- 329 people
- Sponsor
- Lotung Poh-Ai Hospital
Helicobacter Pylori Infection
ILTHPI - Comparison of Medicament Containing Tetracycline, Metronidazole, Bismuth Versus Amoxicillin, Metronidazole, Clarithromycin
Helicobacter pylori (H. pylori) is a spiral shaped, microaerophilic, gram negative bacterium. The organism resides in the acid and mucous layer of the human gastric mucosa, adheres to and colonizes the mucosal surface of the…
- Trial name
- NCT04853875
- Testing
- Tetracycline, Metronidazole, Bismuth subcitrate, Amoxicillin, Metronidazole, Clarithromycin
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- Mackay Memorial Hospital
Ischemic Heart Disease
Patterns of Antiacids Use in Patients With IHD Admitted to Department of Internal Medicine
There is substantial, continuing, and unexplained rise in prescribing of proton pump inhibitors. It is unknown whether their use in practice has corresponded to their licensed indications.
- Trial name
- NCT00392964
- Where
- 2 sites in Israel
- Volunteers
- 1,200 people
- Sponsor
- Rambam Health Care Campus
Globus
Treatment in Patients With Globus: Psychoeducation, Anxiolytics or Proton Pump Inhibitors
A randomized controlled trial study is conducted to compare treatment efficacy between psycho-education, anxiolytics drug and proton pump inhibitors in participants who met the criteria of globus.
- Trial name
- NCT03205228
- Testing
- Omeprazole, psychoeducation, Flupentixol +Melitracen
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Healthy Volunteer
A Study to Assess the Potential for Gastric-pH Dependent Drug-Drug Interactions of BIIB122 With a Proton Pump Inhibitor in Healthy Participants
The primary objective of the study is to evaluate the effects of a proton pump inhibitor (PPI) [rabeprazole] on BIIB122 pharmacokinetics (PK) after a single dose in healthy participants.
- Trial name
- NCT06264440
- Testing
- BIIB122, Rabeprazole
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Biogen
Helicobacter Pylori Infection
The Role of Probiotics in the Eradication of Helicobacter Pylori
All patients will receive quadruple eradication therapy for 10 days with Omerazole 20mg x2, Amoxicilin 1g x2, Clarithromycin 500mg x2 and Metronidazole 500mg x2. The patients will be randomised into two groups.
- Trial name
- NCT04178187
- Testing
- Caps Lactolevure
- Where
- 5 sites in Greece
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Gastro-esophageal Reflux
Post Prandial High Resolution Impedance- Manometry
Nine to 30% of the population suffers from gastro-esophageal reflux disease (GERD) - suggestive symptoms (heartburn, regurgitation, chest pain, chronic couch, sore throat).
- Trial name
- NCT03306485
- Testing
- Correlating the number of reflux episodes detected on 1-h post prandial esophageal high resolution manometry combined and those detected on ambulatory 24-h pH-impedance monitoring performed on PPI
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
GERD
A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes
Backgrounds \& Aims: Proton-pump inhibitor (PPI) test has been proposed as a valuable tool in the diagnosis of gastroesophageal reflux disease (GERD) in Western populations.
- Trial name
- NCT00681005
- Testing
- rabeprazole, pantoprazole
- Volunteers
- 178 people
- Sponsor
- National Taiwan University Hospital
Healthy Volunteer
Proton Pump Inhibitor (PPI, Rabeprazole) Effect On Tablet Formulation Of Palbociclib
to evaluate the effect of the PPI (rabeprazole) on the PK of a potential commercial tablet formulation of palbociclib
- Trial name
- NCT03220191
- Testing
- Palbociclib, Rabeprazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Subjects
Study to Assess the Pharmacokinetic Drug-Drug Interactions of Lemborexant When Coadministered With an Oral Contraceptive, Famotidine, or Fluconazole in Healthy Subjects
This study will be conducted to evaluate the effect of lemborexant 10 milligrams (mg) (at steady state) on the pharmacokinetics (PK) of a single-dose combined oral contraceptive, Loestrin 1.5/30 (containing 0.030 mg of ethinyl…
- Trial name
- NCT03451110
- Testing
- lemborexant, Loestrin, famotidine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
GERD
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
Background: Gastroesophageal reflux disease (GERD), which affects at least 20% of adult Americans, may be especially common and severe in Veteran patients.
- Trial name
- NCT01265550
- Testing
- Nissen fundoplication, baclofen, Desipramine
- Where
- 15 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy
A Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of BMS-986205 in Healthy Participants
The purpose of this study is to assess the effect of multiple dose administrations of Omeprazole on the pharmacokinetics of BMS-986205.
- Trial name
- NCT03936374
- Testing
- BMS-986205, omeprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb