Clinical trials: Proton Therapy
Healthy Volunteers
A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants
This Phase 1 study evaluates the effect of pantoprazole (a proton pump inhibitor) on the pharmacokinetics (PK) of CHF10196 (Florensocatib) in healthy male participants.
- Trial name
- NCT07683793
- Testing
- CHF10196, Pantoprazole
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Primary Glioblastoma
Carbon Ion Radiotherapy for Primary Glioblastoma
Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons.
- Trial name
- CLEOPATRA (NCT01165671)
- Testing
- Carbon Ion Radiotherapy, Proton Radiotherapy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Heidelberg
Breast Cancer
A Prospective Cohort Study of Proton and Photon Therapy for Left-sided Breast Cancer.
The goal of this study is to investigate the differences in toxicity and efficacy between proton and photon hypofractionated radiotherapy following lumpectomy or mastectomy for breast cancer.
- Trial name
- NCT06677879
- Testing
- Proton radiotherapy, Photon radiotherapy
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Cervical Cancer
Extended-field Proton Therapy for Cervical Cancer
Severe lymphopenia is a common complication of extended-field radiotherapy in cervical cancer, significantly impacting immune function and clinical outcomes.
- Trial name
- NCT07298642
- Testing
- Proton extended field radiation therapy, Photon extended field radiation therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 44 people
- Sponsor
- National Taiwan University Hospital
Gastroesophageal Reflux
Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD
This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms.
- Trial name
- NCT05556824
- Testing
- MHS-1031
- Where
- 18 sites in United States
- Volunteers
- 255 people
- Sponsor
- Microbiome Health Sciences
Breast Cancer
Monitoring Response to Neoadjuvant Chemotherapy by the Use of Breast Proton MR Spectroscopy
This study is being done to evaluate if MR spectroscopy will give us more information about whether or not your chemotherapy will work for you.
- Trial name
- NCT00580086
- Testing
- MR spectroscopy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Cancer, Proton Therapy
Proton Therapy for Locally Advanced Cervical Cancer
The purpose of this protocol is to determine toxicity and efficacy of proton therapy in combination with standard concomitant platinum-based chemotherapy and standard image-guided adaptive brachytherapy (IGABT) in patients with…
- Conditions
- Cervical Cancer, Proton Therapy, Radiotherapy Side Effect
- Trial name
- NCT06462378
- Testing
- Proton therapy
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- University of Aarhus
Gastro Esophageal Reflux
Effect of a Combination of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate on Subjects With GastroEsophageal Reflux Disease
The aim of this study is to investigate whether a 3-week treatment with an oral melt in mouth medical device, made up with hyaluronic acid, chondroitin sulphate and magnesium trisilicate, can lead to a reduction of…
- Trial name
- NCT03883074
- Testing
- hyaluronic acid with chondroitin + sulphate + magnesium trisilicate
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- SOFAR S.p.A.
Erosive Reflux Disease, Non-erosive Reflux Disease
Predictors of Proton Pump Inhibitor Response in Gastroesophageal Reflux Disease Patients
Proton pump inhibitor (PPI) is widely used in patients with gastroesophageal reflux disease (GERD), however, some patients fail to respond to PPI therapy.
- Conditions
- Erosive Reflux Disease, Non-erosive Reflux Disease, Functional Heartburn
- Trial name
- NCT01797939
- Where
- South Korea
- Volunteers
- 197 people
- Sponsor
- Seoul National University Bundang Hospital
Multiple Sclerosis
Drug-Drug Interaction of Cladribine and Pantoprazole in Multiple Sclerosis Subjects
The purpose of the study is to assess the influence of pantoprazole on the pharmacokinetic profile of cladribine, especially in terms of extent of absorption of cladribine since pH-modifying drug may potentially affect the…
- Trial name
- NCT00938366
- Testing
- Cladribine, Pantoprazole
- Volunteers
- 18 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
H Pylori
Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment…
- Trial name
- NCT07040839
- Testing
- Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg
- Where
- Pakistan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Early-Stage Breast Cancer
Proton Therapy for Early Stage Breast Cancer
The purpose of this study is to determine if partial breast proton therapy is effective treatment for early stage breast cancer following lumpectomy.
- Trial name
- NCT00614172
- Testing
- Proton radiation therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Prostate Adenocarcinoma
Mild Hypofractionation With Proton Therapy or IMRT for Intermediate-Risk Prostate Cancer
This is a study to first establish feasibility of the study and then to register the treatment data of adult patients with a diagnosis of intermediate risk of prostate cancer presenting for definitive radiation treatment with…
- Trial name
- NCT01352429
- Testing
- Proton Therapy, IMRT
- Where
- 2 sites in United States
- Volunteers
- 303 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Soft Tissue Sarcoma of the Extremities
Proton Radiotherapy for Extremity Soft Tissue Sarcoma
This is a study of proton radiotherapy for the pre- or post- operative treatment of patients with extremity sarcoma. This study will treat patients in two dose groups: 1. patients receiving pre-operative proton therapy and 2.
- Trial name
- NCT01561495
- Testing
- Proton Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Retroperitoneal Sarcoma
Proton-Spatially Fractionated Radiotherapy and Standard Radiation Therapy for the Treatment of Newly Diagnosed Retroperitoneal Soft Tissue Sarcoma
This phase I/II trial studies the side effects and best dose of proton-spatially fractionated radiotherapy (P-SFRT) and to see how well it works with standard radiation therapy in treating patients with newly diagnosed…
- Trial name
- NCT06327477
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Northwestern University
Colorectal Neoplasms, Gastrointestinal Stromal Tumors
The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib
Regorafenib is a novel oral multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinases. It is currently registered for GIST and mCRC.
- Trial name
- REGORA (NCT02800330)
- Testing
- Esomeprazole 40mg concomitantly, Esomeprazole 40mg before, Regorafenib 160mg or 120mg
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Erasmus Medical Center
Adverse Events
Strategies for Improving Proton Pump Inhibitors (PPIs) Prescription Associated to Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Background Despite the low prevalence of serious complications associated with non-steroidal anti-inflammatory drugs (NSAIDs) use, there is a widespread use of gastroprotective proton pump inhibitors (PPIs) in order to prevent…
- Trial name
- NCT01128127
- Testing
- Group education, audit-feedback and computer support, Audit-feedback and computer support, Control
- Where
- Spain
- Sponsor
- Servicio Canario de Salud
Type 2 Diabetes
Effect of Liraglutide on Fatty Liver Content and Lipoprotein Metabolism
Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. NAFLD, in patients with type 2 diabetes, has been shown to be associated with lipid abnormalities (such as…
- Trial name
- LIRA-NAFLD/LIP (NCT02721888)
- Testing
- Liraglutide, MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy), Blood sample
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Metastatic Malignant Neoplasm in the Lung, Recurrent Disease
Proton Beam Re-Irradiation in Thoracic Cancers
This pilot clinical trial studies proton beam radiation therapy in treating patients with thoracic cancer that has come back and have received prior radiation therapy.
- Conditions
- Metastatic Malignant Neoplasm in the Lung, Recurrent Disease, Thoracic Neoplasm
- Trial name
- NCT02204761
- Testing
- Proton Beam Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Washington
Gastric Lesion, Proton Pump Inhibitor Adverse Reaction
Lactobacillus Reuteri Strain Combination in Children Treated With PPI
Probiotics might be of help in preventing dysbiosis and emergence of SIBO. Gastrus consisted of a mixture of two human strains of L.
- Conditions
- Gastric Lesion, Proton Pump Inhibitor Adverse Reaction, Probiotic
- Trial name
- NCT05484128
- Testing
- Gastrus
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- University of Bari