Clinical trials: Proton-therapy
Vitamin D
The Influence of Proton Pump Inhibitors (PPI's) on Blood Levels of 25-Hydroxyvitamin D.
The purpose of this study is to demonstrate if Proton Pump Inhibitors (PPI's) decrease blood levels of 25-Hydroxyvitamin D (25-OH Vitamin D).
- Trial name
- NCT01302704
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
H Pylori
Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment…
- Trial name
- NCT07040839
- Testing
- Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg
- Where
- Pakistan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Healthy Volunteers
A Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0941 and the Effect of Food and Proton Pump Inhibition on GDC-0941 Tablet Pharmacokinetics in Healthy Volunteers
This is a Phase I, randomized, two-part, single-center pharmacokinetics (PK) study to assess the relative bioavailability of capsule and tablet formulations of GDC-0941 in the fasted state (Part 1) and to determine the effect of…
- Trial name
- NCT00999128
- Testing
- GDC-0941, rabeprazole
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Participants
A Study to Investigate the Relative Bioavailability of 2 Different Formulations of AZD4144, the Effect of Food and Omeprazole on the Pharmacokinetics of AZD4144 in Healthy Participants
The main aim of this study to compare the pharmacokinetics (PK) of two formulations of AZD4144 and assess the effect of food and omeprazole on PK of AZD4144 in healthy participants.
- Trial name
- NCT06948006
- Testing
- AZD4144, Omeprazole
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity
Bone Marrow Adipose Tissue in Relation to Bone and Energy Metabolism in Obesity and Type 2 Diabetes Mellitus
This interventional study is part of a broader research project entitled "Bone Marrow Adipose Tissue in Relation to Bone and Energy Metabolism in Obesity and Type 2 Diabetes Mellitus." The broader project includes both a…
- Trial name
- BOD-BMAT (NCT07731438)
- Testing
- Caloric Restriction
- Where
- 3 sites in Czechia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- General University Hospital, Prague
Healthy Volunteers
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
The primary purpose of this study is to assess the effects of rifampin on the PK of brensocatib in Part 1 of the study and to assess the effects of esomeprazole on the PK of brensocatib in Part 2 of the study.
- Trial name
- NCT05826574
- Testing
- Brensocatib, Rifampin, Esomeprazole
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Proton Pump Inhibitor Allergy
Effect of Daily Use Proton Pump Inhibitors for One Month on Kidney Function
The aim of this study to: evaluate the association between prolonged use of PPI and adverse renal outcomes on patients with normal renal function and others with abnormal renal function
- Trial name
- NCT03910647
- Testing
- pantoprazole
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Barretts Esophagus With Dysplasia
The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus
This study evaluates the addition of an alginate based solution to twice daily proton pump inhibitor therapy (PPI) in patients undergoing ablative therapy for dysplastic Barrett's esophagus.
- Trial name
- NCT03193216
- Testing
- Alginates
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy
Placebo-Controlled Crossover Study for the Investigation of the Effect of Pantoprazole on Cardiac Contractility
Recently, negative inotropy of pantoprazole has been shown in isolated human myocardium. This study was designed to test the clinical relevance of this finding in healthy volunteers by measuring left ventricular function during…
- Trial name
- HIPPO (NCT00600041)
- Testing
- Pantoprazole
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Herzzentrum Goettingen
Healthy Volunteer
Relative Bioavailability and Drug-drug Interaction Study With MT-7117 and a Proton Pump Inhibitor
An open label, multicentre, randomised, 2-cohort, sequential and crossover study to assess the relative oral bioavailability of MT-7117 higher content tablets versus MT-7117 lower content tablets and the pharmacokinetics of…
- Trial name
- MT-7117 BA DDI (NCT03688022)
- Testing
- MT-7117, PPI, Acidic beverage
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma America, Inc.
Dysbiosis, Gastroesophageal Reflux Disease (GERD)
Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users
Proton-pump inhibitors (PPIs) are widely used to treat acid-related stomach problems, such as heartburn and acid reflux. Long-term use of PPIs has been linked to changes in the gut bacteria and fungi (called the gut microbiota)…
- Trial name
- NCT07852676
- Testing
- Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI)
- Where
- 3 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Breast Diseases
The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy
To delineate if the chemical composition (lipid and water) in the presumably normal breast of the high risk women is different from those of the low risk group.
- Trial name
- NCT01749748
- Testing
- proton magnetic resonance spectroscopy
- Where
- Taiwan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acidosis, Renal Tubular, Nephrolithiasis
Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Purpose 1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test. 2.
- Conditions
- Acidosis, Renal Tubular, Nephrolithiasis, Vacuolar Proton-Translocating ATPases
- Trial name
- NCT01690039
- Testing
- Furosemide-Fludrocortisone-Test (test for urinary acidification)
- Where
- Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Mantle Cell Lymphoma, COVID-19
A Study in Healthy Subjects to Assess Bioavailability (Proportion of a Drug Which Enters the Circulation to Have an Active Effect) of Acalabrutinib Tablet and Protonpump Inhibitor Effect (Members of a Class of Medications That Inhibits in Gastric Acid Production) for Rabeprazole
This Phase 1 study is being conducted to support the clinical development of acalabrutinib in hospitalized patients who are unable to swallow acalabrutinib tablet or capsule due to respiratory failure, eg, they may require…
- Trial name
- NCT04564040
- Testing
- Acalabrutinib Treatment A, Acalabrutinib Treatment B, Acalabrutinib Treatment C
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Participants
Study to Evaluate Safety, Drug Levels, Food and Relative Bioavailability of BMS-986365 in Healthy Adult Male Participants
The purpose of this study is to evaluate the safety, tolerability, drug levels, food effects and relative bioavailability of BMS-986365 in healthy male participants.
- Trial name
- NCT06417229
- Testing
- BMS-986365, Rabeprazole
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Celgene
Hepatitis C, Swallowing Disorder
Influence of Cola on the Absorption of the HCV Agent Velpatasvir in Combination With PPI Omeprazole.
Epclusa® is a pan-genotypic, once-daily tablet for the treatment of chronic hepatitis C virus (HCV) infection containing the NS5B- polymerase inhibitor sofosbuvir (SOF, nucleotide analogue) 400 mg and the NS5A inhibitor…
- Trial name
- COPA (NCT03513393)
- Testing
- velpatasvir
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy Volunteers
Effect of Proton Pump Inhibitors on Gut Microbiota and Systemic Inflammation in Older Adults
The purpose of this study is to evaluate the effects of a common over-the-counter medication, omeprazole, on the normal gut bacteria and inflammation in the body in healthy older adults.
- Trial name
- NCT02844621
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Postprandial IHL and IMCL Dynamics
Postprandial IHL and IMCL Measured With Proton Magnetic Resonance Spectroscopy
The major research objective is to assess the potential of Proton Magnetic Resonance Spectroscopy to follow Intrahepatic lipid and Intramyocellular lipid dynamics after a single meal.
- Trial name
- NCT01709643
- Testing
- High fat breakfast, HF breakfast with protein
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Safety and Tolerability of SYNB1934 in Healthy Adult Volunteers
This Phase 1, first-in-human, multiple dose-escalation, randomized, double-blinded, placebo-controlled study is evaluating SYNB1934 in healthy volunteers (HV).
- Trial name
- NCT04984525
- Testing
- SYNB1934, SYNB1618
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Synlogic
Major Depressive Disorder
Treatment Resistant Geriatric Depression in Primary Care
This study involves collaboration between McLean Hospital, Geriatric Medicine at the Cambridge Health Alliance (CHA) and other sites within the Partners and Harvard Medical School network.
- Trial name
- NCT01392287
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital