Clinical trials: Provoked Vestibulodynia
Localized Provoked Vulvodynia
The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia
The proposed study will evaluate how personality characteristics, cognitive factors and the emotional and behavioral responses of patients with provoked vestibulodynia (localized provoked vulvodynia) influence the natural history…
- Trial name
- NCT02892214
- Testing
- Pelvic floor physical therapy, estriol cream (ovestin), Low-level-laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Vulvodynia
High-level Laser for Provoked Vestibulodynia
This is a randomized feasibility and acceptability study investigating the effects of laser treatment in women suffering from provoked vestibulodynia compared to a sham-laser treatment.
- Trial name
- NCT04502810
- Testing
- High-level laser therapy
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Université de Sherbrooke
Vulvar Vestibulitis, Vestibulodynia
Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief
The objectives of this pilot study are to demonstrate effectiveness of application of the Erchonia Laser (manufactured by Erchonia Corporation),a non-invasive, non-significant risk low level laser red diode light therapy device…
- Trial name
- NCT02204319
- Testing
- Cold laser
- Volunteers
- 10 people
- Sponsor
- ProHealth Care, Inc
Vestibulodynia
Feasibility Study for Provoked Vestibulodynia
The feasibility and acceptability of a somatosensory rehabilitation program and an educational pain management program will be investigated in women with provoked vestibulodynia.
- Trial name
- NCT05342402
- Testing
- Somatosensory Rehabilitation Program, Educational Pain Management Program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Vestibulodynia
A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia
The main objective of this study is to compare the efficacy of botulinum toxin injections on vestibulodynia pain compared to a group treated with a placebo.
- Trial name
- VESTIBULE (NCT02858219)
- Testing
- Botulinum Toxin Type A, Saline solution, Indexes
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Dyspareunia
What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?
Dyspareunia, or pain experienced by women during penetrative sexual activities, affects the psychological and sexual health of more than one in five Canadian women [1], yet its pathophysiology is poorly understood [2-4] and…
- Trial name
- NCT04234555
- Testing
- Corticomotor excitability to the pelvic floor muscles, Pelvic floor muscle response to pressure applied at the vulvar vestibule, Pressure pain threshold (PPS)
- Where
- Canada
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Provoked Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked Vestibulodynia - a Feasibility Study
This study examines feasibility of R\&D activities in the planned randomized controlled trial where effectiveness of somatocognitive therapy intervention will be compared to treatment as usual in provoked vestibulodynia.
- Trial name
- ProLoVe (NCT04208204)
- Testing
- somatocognitive physiotherapy
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Vestibulodynia
Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia
Vulvodynia is a debilitating chronic vulvar pain lasting at least 3 months without a clear identifiable cause that is challenging to treat effectively.
- Trial name
- NCT03390049
- Testing
- Fractional CO2 Laser Treatment
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Vulvodynia, Vestibulodynia
Effects of Flourish HEC on Localized Provoked Vulvodynia
This study is designed to determine whether improving the vaginal microbiome in women with localized provoked vulvodynia (LPV) may help improve pain better than routine care alone.
- Conditions
- Vulvodynia, Vestibulodynia, Vulvar Diseases, Vulvar Vestibulitis
- Trial name
- NCT05478746
- Testing
- BioNourish, a component of the Flourish HEC kit, Control - no intervention
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vaginal Biome Science
Vulvodynia, Dyspareunia
Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia
Chronic pain problems involving the female reproductive system are major health concerns for all women. Poorly understood, they entail great personal and financial cost.
- Conditions
- Vulvodynia, Dyspareunia, Vestibulodynia
- Trial name
- CBCT-RCT (NCT01935063)
- Testing
- Cognitive Behavioral Couple Therapy, Topical Lidocaine
- Where
- 2 sites in Canada
- Volunteers
- 108 people
- Sponsor
- Université de Montréal
Vulvodynia
Efficacy of High Intensity Laser for Provoked Vestibulodynia
This is a multicenter randomized controlled trial (RCT) investigating the effects of laser treatments in women suffering from provoked vestibulodynia compared to a sham-laser treatment.
- Trial name
- Laser_RCT (NCT05597358)
- Testing
- High Intensity Laser Therapy (HILT)
- Where
- 4 sites in Canada
- Volunteers
- 145 people
- Sponsor
- Université de Sherbrooke
Vulvar Vestibulitis
Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia
The purpose of the study was to compare the effectiveness of cognitive behavioural therapy (CBT) and physical therapy (PT) on pain and psychosexual outcomes in women with provoked vestibulodynia (PVD).
- Trial name
- NCT02494934
- Testing
- cognitive-behavioural therapy, physical therapy
- Volunteers
- 20 people
- Sponsor
- Queen's University
Vestibulodynia
Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia
Chronic gynaecological pain is a major medical problem that affects 20-30% of women at different moments of their life. This largely neglected issue has a significant impact on the sexual and conjugal life of women suffering from…
- Trial name
- NCT01455350
- Testing
- Multimodal physiotherapy, lidocaine
- Where
- 2 sites in Canada
- Volunteers
- 212 people
- Sponsor
- Université de Sherbrooke
Provoked Localized Vulvodynia
Subtypes of Provoked Vestibulodynia
The proposed study will evaluate a clinical algorithm for the diagnosis and treatment of provoked vestibulodynia (PVD). The algorithm, distinguishes between four subtypes of PVD: hormonally mediated PVD, hypertonic pelvic floor…
- Trial name
- NCT02712814
- Testing
- Topical hormonal cream (estrogen), Pelvic floor physical therapy, Low Level Laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Vulvodynia
Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareuni and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT04057755
- Testing
- botulinum toxin A, NaCl
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Provoked Vestibulodynia
The Use of Low Intensity Shock Wave Therapy for the Treatment of Provoked Vestibulodynia Disorder (PVD)
Provoked vestibulodynia (PVD) is an exhausting pain syndrome that immensely affects quality of sexual life, and consequently negatively affects quality of life.
- Trial name
- NCT04545255
- Testing
- Shockwave treatment
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Sexual Pain Disorders, Postmenopausal Symptoms
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
This study will evaluate the use of topical 5 or 10% sinecatechins, a botanical drug derived from green tea for the alleviation of sexual pain in the area around the vaginal opening (the vulvar vestibule), that is a main source…
- Conditions
- Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy, Female Sexual Dysfunction
- Trial name
- NCT03682601
- Testing
- 5% sinecatechins ointment, 10% sinecatechins ointment
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GTO Pharmaceutical, LLC
Vulvodynia, Vulvar Vestibulitis
Acupuncture for the Treatment of Vulvodynia
A randomized controlled pilot study was conducted to evaluate the effect of an acupuncture protocol for the treatment of vulvodynia. Hypotheses: 1. Acupuncture reduces vulvar pain and dyspareunia in women with vulvodynia. 2.
- Conditions
- Vulvodynia, Vulvar Vestibulitis, Pain, Dyspareunia
- Trial name
- NCT02197429
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Schlaeger, Judith M., CNM, LAc, PhD
Provoked Vestibulodynia
Investigating the Effectiveness of PelvicSense(R) on Pain and Sexual Outcomes in Provoked Vestibulodynia
This study will examine the effectiveness of the PelvicSense 3-month online program on pain and other outcomes in those with provoked vestibulodynia.
- Trial name
- NCT05909514
- Testing
- PelvicSense(R)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Dr. Caroline Pukall
Provoked Vestibulodynia
Dry Needling for Provoked Vestibulodynia
This is a randomized and controlled study investigating the feasibility and acceptability of a dry needling treatment for women suffering from provoked vestibulodynia.
- Trial name
- NCT05797480
- Testing
- Real Dry needling, Non penetrating dry needling
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Université de Sherbrooke