Clinical trials: Proximal Gastric Cancer
Malignant Gastric Outlet Obstruction
Roux-en-Y Gastric Bypass Versus Loop Gastrojejunostomy for Malignant Gastric Outlet Obstruction
This study is intended to investigate whether roux-en-y bypass surgery is superior to conventional loop gastrojejunostomy for Malignant gastric outlet obstruction in terms of tolerance to solid food intake.
- Trial name
- NCT05986890
- Testing
- Roux-en-Y Bypass, gastrojejunostomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Corewell Health West
Gastric Cancer
Conversion Therapy of Camrelizumab Plus Chemoradiotherapy in Participants With Initial Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
This is a study of Camrelizumab in Combination With concurrent radiotherapy and SOX for Initial Unresectable or potentially resectable proximal Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma.
- Trial name
- NCT04631757
- Testing
- Camrelizumab + SOX + Radiotherapy
- Volunteers
- 33 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Proximal Gastric Adenocarcinoma, Gastric Cancer
Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer
This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer.
- Conditions
- Proximal Gastric Adenocarcinoma, Gastric Cancer, Gastroesophageal Reflux Disease
- Trial name
- NCT05514769
- Testing
- Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanchong Central Hospital
Gastric Adenocarcinoma, Gastrectomy
PG Versus TG for Advanced PGC
We conducted a retrospective study on patients with pathological stage II-III PGC who underwent PG or TG from 2013 to 2023. Propensity score-matching was applied to adjust for tumor size and stage between the PG and TG groups at…
- Trial name
- NCT06614439
- Testing
- proximal gastrectomy, total gastrectomy
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- National Taiwan University Hospital
Gastric (Stomach) Cancer
Comparison of Channel Esophagogastrostomy and Double Tract Reconstruction After Laparoscopic-assist Proximal Gastrectomy: A Propensity Score-Matched Analysis
This retrospective cohort study enrolled adult patients who underwent LAPG between September 2020 and September 2023 at Northern Jiangsu People's Hospital.
- Trial name
- NCT06741124
- Testing
- Channel Esophagogastrostomy, Double Tract Reconstruction
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Northern Jiangsu People's Hospital
Esophageal Cancer, Gastric Cancer
A Study Evaluating Safety and Efficacy of Niraparib in Patients With Previously Treated Metastatic Esophageal/Gastroesophageal Junction/Proximal Gastric Adenocarcinoma
Patients can be prescreened for the study at the time of diagnosis of locally advanced or metastatic disease by determining presence of LOH high status and/or deleterious alterations in HR pathway genes in the most recent…
- Conditions
- Esophageal Cancer, Gastric Cancer, Adenocarcinoma
- Trial name
- NCT03840967
- Testing
- Niraparib
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Shadia Jalal, MD
Locally Advanced Gastric Cancer
Proximal Gastrectomy vs Total Gastrectomy in Locally Advanced Upper Gastric Cancer After Neoadjuvant Therapy
We plan to evaluate the efficacy and safety of proximal gastric vs. total gastric radical resection after SOX combined with anti-PD-1 neoadjuvant therapy in locally advanced upper gastric cancer
- Trial name
- TJHGC01 (NCT06597227)
- Testing
- Proximal radical gastrectomy, Total radical gastrectomy
- Where
- China
- Volunteers
- 404 people
- Sponsor
- Guihua Wang
Gastric Cancer, Adenocarcinoma of Esophagogastric Junction
A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique
This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach…
- Trial name
- NCT06300879
- Testing
- Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital
Stomach Neoplasms
Laparoscopic Proximal Gastrectomy With Double-flap Technique Versus Laparoscopic Total Gastrectomy With Roux-en-Y Reconstruction for Proximal Early Gastric Cancer
Proximal early gastric cancer can choose radical total gastrectomy or proximal gastrectomy. But if use simple esophagogastric anastomosis for proximal gastrectomy, the incidence of postoperative reflux esophagitis is up to 62%…
- Trial name
- NCT05890339
- Testing
- Laparoscopic Proximal Gastrectomy With Double-flap Technique, Laparoscopic Total Gastrectomy With Roux-en-Y Reconstruction
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Gastric Cancer, GastroEsophageal Cancer
A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers
Participants will a diagnosis of gastroesophageal junction (GEJ) adenocarcinoma and will have either a minimally invasive proximal gastrectomy (MIPG) or a minimally invasive total gastrectomy (MITG) as part of their routine care.
- Conditions
- Gastric Cancer, GastroEsophageal Cancer, Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT06243757
- Testing
- MDASI-GI
- Where
- 8 sites in United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stomach Neoplasms, Adenocarcinoma - Gastroesophageal Junction (GEJ)
The Efficacy and Safety of Laparoscopic Proximal Gastrectomy With LPG-tbROSF Versus LTG for Localized Proximal Gastric Cancer.
This clinical trial is evaluating a new, function-preserving surgical technique for patients with early-stage cancer in the upper part of the stomach.
- Conditions
- Stomach Neoplasms, Adenocarcinoma - Gastroesophageal Junction (GEJ), Gastroesophageal Junction Cancer
- Trial name
- NCT07260461
- Testing
- Laparoscopic Proximal Gastrectomy with Tubular Stomach-Based Right-Opening Single Flap Valvuloplasty (LPG-tbROSF)
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Gastric Cancer
Safety Comparison of Total Laparoscopic Proximal Gastrectomy With or Without Preservation of the Celiac Branch of the Vagus Nerve for Early Upper Gastric Cancer: A Randomized Controlled Clinical Trial
This prospective, single-center, randomized, controlled, non-inferiority clinical trial aims to compare the safety and postoperative quality of life of early upper gastric cancer patients undergoing total laparoscopic proximal…
- Trial name
- TLPG-CBVP (NCT07142122)
- Testing
- Total laparoscopic proximal gastrectomy with preservation of both the hepatic and celiac branches of the vagus nerve, followed by double-tract reconstruction., Total laparoscopic proximal gastrectomy with preservation of the hepatic branch of the vagus nerve but deliberate resection of the celiac branch, followed by double-tract reconstruction.
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Fujian Cancer Hospital
Gastric Cancer, Proximal Gastric Adenocarcinoma
Surveillance Endoscopy After Proximal Gastriectomy With Double Tract Reconstruction.
The primary purpose of surveillance endoscopy after gastric cancer surgery is to detect malignancy recurrence in the remnant stomach.
- Trial name
- NCT06477562
- Testing
- Endoscopy
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Saint Vincent's Hospital, Korea
Gastric Cancer (GC), Double-tract Reconstruction
Comparison of Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer
This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA).
- Conditions
- Gastric Cancer (GC), Double-tract Reconstruction, Tubular Gastric Anastomosis
- Trial name
- NCT07635836
- Testing
- Double-tract reconstruction
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Qilu Hospital of Shandong University
Complications, Quality of Life
Double Tract Anastomosis and Gastric Tube Anastomosis to Proximal Gastrectomy
Gastric cancer as one of the most common gastrointestinal cancers, radical resection of primary lesions combined with dissection of regional lymph-nodes is acknowledged by surgeons all over the world.
- Conditions
- Complications, Quality of Life, Remnant Gastritis, Reflux Esophagitis
- Trial name
- DTA>A (NCT02288728)
- Testing
- Gastric tube anastomosis, Double-track anastomosis
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Jian-Kun Hu
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Proximal Early Gastric Cancer
The Anti-reflux Effect of Double-flap Technique in Laparoscopic Proximal Gastrectomy.
This study is a multicenter, open-label, prospective, randomized parallel-controlled trial. The purpose is to explore whether the incidence rate of reflux esophagitis (RE) within 12 months after surgery is non-inferior for the…
- Trial name
- NCT06511609
- Testing
- double-flap technique（DFT）; double-tract reconstruction(DTR),
- Volunteers
- 244 people
- Sponsor
- Changzhi People's Hospital Affiliated to Changzhi Medical College
Stomach Neoplasms, Robotic Surgical Procedures
Single-port Versus Conventional Laparoscopic Surgery for Radical Proximal Gastric Cancer: A Randomized Controlled Trial
To evaluate the safety and efficacy of SP1000 and conventional laparoscopy in radical gastrectomy for proximal gastric cancer.
- Trial name
- NCT07586384
- Testing
- Single-Port Robotic Surgical System, Traditional Laparoscopic Surgery
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Pancreatic Cancer, Bile Duct Cancer
Proximal Roux-en-y Gastrojejunal Anastomosis on Delayed Gastric Emptying After Pylorus-resecting Pancreaticoduodenectomy
This study aims to evaluate whether the incidence of delayed gastric emptying (DGE) can be reduced by proximal Roux-en-y gastrojejunal anastomosis in comparison with the standard gastrojejunal anastomosis in pylorus-resecting…
- Conditions
- Pancreatic Cancer, Bile Duct Cancer, Duodenal Cancer
- Trial name
- NCT02954302
- Testing
- PrPD with proximal Roux-en-y gastrojejunal anastomosis, conventional PrPD
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Gastric Cancer
Comparison of Laparoscopic Proximal Gastrectomy and Laparoscopic Total Gastrectomy
Experimental: Laparoscopic proximal gastrectomy Laparoscopy proximal gastrectomy with esophago-jejunostomy, gastro-jejunostomy and jejuno-jejunostomy (double tract reconstruction).
- Trial name
- NCT02892643
- Testing
- Laparoscopic proximal gastrectomy, Laparoscopic total gastrectomy
- Where
- 16 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- Seoul National University Bundang Hospital