Clinical trials: Pruritis
Chronic Kidney Disease-associated Pruritus
Klotho in Chronic Kidney Disease-associated Pruritis (CKD-aP)
Studying whether Klotho and FGF23 have a role in UP and whether their expression change by BB-UVB with the improvement of pruritus.
- Trial name
- NCT03532568
- Testing
- skin biopsy, narrowband ultraviolet B
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Itch
Topographical Distribution of Itch and Pain Receptors
The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about…
- Trial name
- NCT07122973
- Testing
- Histamine, Cowhage, Capsaicin 8% Patch
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus
Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
In order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the…
- Trial name
- NCT04399148
- Testing
- Desloratadine 5 mg, Aprepitant 125 mg, Ketotifen 1 MG
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus
Itch Relieving Effect of Botox: a Study in Healthy Subjects
The purpose of this study is to determine if Botox is effective in the treatment of an experimentally induced itch that mimics chronic itch in healthy volunteers.
- Trial name
- NCT02639052
- Testing
- Botox, Saline
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Temple University
Histamine, Cowhage
Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)
In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli.
- Trial name
- NCT06328543
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus, Cholestasis
Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus
This first in human, Phase 1/1b trial will evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending doses of EP547 in healthy subjects and subjects with cholestatic or uremic pruritus.
- Conditions
- Pruritus, Cholestasis, Kidney Failure
- Trial name
- NCT04510090
- Testing
- EP547
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Escient Pharmaceuticals, Inc
Scald Burn, Itching
Comparison of the Effects of Liquid Vaseline and Olive Oil on Itching and Scarring in Scald Burns
Pain, itching, hypertrophic scar formation after wound healing in burn patients complications, sleep disturbances in patients, anxiety, depression, and daily life It may disrupt activities and deterioration in quality of life.
- Conditions
- Scald Burn, Itching, Hypertrophic Scarring
- Trial name
- NCT06104540
- Testing
- Experimental I liquid vaseline groups, Experimental II extra virgin olive oil groups, Control Croup
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Allergy, Anxiety
The Effects of Virtual Reality and Music on Pain, Anxiety, Itching, and Vital Signs
Aim: This study aimed to examine the effects of virtual reality and music on pain, anxiety, itching, and vital signs of children during a skin prick test and evaluation.
- Conditions
- Allergy, Anxiety, Pain, Itching
- Trial name
- NCT06479967
- Testing
- The VR glasses group, the music group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Uludag University
Healthy
Topical Tripelennamine 1% Cream Versus Diphenhydramine 1% Cream for the Relief of Histamine-Induced Itching: A Proof Concept Study in Healthy Adults.
The goal of this clinical trial is to determine whether topical tripelennamine 1% cream can relieve histamine-induced itching and whether it is more effective than diphenhydramine 1% cream in healthy adults aged 18 to 50 years.
- Trial name
- NCT07778472
- Testing
- Tripelennamine, Diphenhydramine, Vehicle Control Cream Base
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Palm Beach Atlantic University
Histamine, Cowhage
Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: To investigate similarity and differences between itch and pain by comparing the effect of sleep…
- Conditions
- Histamine, Cowhage, Sleep Deprivation
- Trial name
- NCT06081998
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Psoriasis, Healthy
Brain Changes in Psoriasis After Secukinumab Treatment
The purpose of this study is to assess the effect of a biologic drug targeting the Interleukin (IL)-17 pathway (secukinumab) on brain plasticity and examine whether the plastic changes correlate with the improvement of perception…
- Trial name
- NCT04717466
- Testing
- Secukinumab
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Morphine, Itch
A Relation of Morphine-induced Itch and Pain Processing
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1.
- Trial name
- NCT04115462
- Testing
- Morphine, Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus
Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin Prick
To determine the effective dose and the time course, the dermal blood flow response to histamine will be evaluated at different doses (5 µg, 15 µg and 50 µg).
- Trial name
- NCT04399213
- Testing
- 50 µg Histamine, 15 µg Histamine, 5 µg Histamine
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pruritus
A Study to Investigate the Receptor Occupancy of SK-1405 in Healthy, Caucasian, Male Subjects
The primary objective is to confirm the target receptor occupancy of SK-1405 and to correlate receptor occupancy with SK-1405 dose and plasma concentration.
- Trial name
- NCT02650076
- Testing
- SK-1405
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Normal Volunteers, Atopic Dermatitis (AD)
Safety, Tolerability and PK of ATTO-3712 in Healthy Volunteers and Patients With Atopic Dermatitis
The goal of this clinical trial is to assess the safety, tolerability, and pharmacokinetics of ATTO-3712 in healthy adults and patients with atopic dermatitis.
- Conditions
- Normal Volunteers, Atopic Dermatitis (AD), Atopic Eczema, Atopic Eczema/Dermatitis (Non-Specific)
- Trial name
- NCT07205081
- Testing
- ATTO-3712
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Attovia Therapeutics Inc
Atopic Dermatitis
The Effect of Intervention and Mechanism of ICBT on Chronic Itching in Patients With Atopic Dermatitis
Objectives: The study subjects were 180 healthy people from the dermatology clinic of Xiangya Hospital of Central South University and the surroundingcommunity, including 120 AD patients (60 in the ICBT treatment group and 60 in…
- Trial name
- NCT05502848
- Testing
- Internet Cognitive Behavior Therapy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Pruritus
Bioequivalence Study of Nalfurafine Hydrochloride Orally Disintegrating Tablets on Fasting and Fed in Humans
The test formulation of Nalfurafine Hydrochloride Orally Disintegrating Tablets (2.5 μg) is bioequivalent to the reference formulation (Remitch®) in healthy Chinese subjects under fed conditions.
- Trial name
- NCT07478133
- Testing
- Nalfurafine Hydrochloride Orally Disintegrating Tablets, Remitch®
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Itch
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity
Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms.
- Trial name
- IL-13 (NCT06503510)
- Testing
- Histamine, Cowhage, bovine adrenal medulla (BAM8-22)
- Where
- 3 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Tinea Pedis, Athlete's Foot
Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females
The topical cream, Sertaconazole (Ertaczo), has been FDA approved for the treatment of athlete's foot using twice a day dosing for 4 weeks.
- Conditions
- Tinea Pedis, Athlete's Foot, Foot Fungus, Ringworm
- Trial name
- NCT00856596
- Testing
- Sertaconazole nitrate cream 2%
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jamaica Hospital Medical Center