Clinical trials: Pruritis
Acne Vulgaris
Comparison of Malassezia Spp Proportions in Inflammatory and Non Inflammatory Facial Acne Vulgaris Lesions
Acne vulgaris (AV) is a common inflammatory condition involving pilosebaceous unit. The pathogenesis of acne is multifactorial and skin microbiome is considered to be one of the key factors that aggravate inflammation.
- Trial name
- NCT04367584
- Testing
- Clinical and laboratory examination
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Acupuncture, Morphine Induced Pruritis
Efficacy of Acupuncture for Prophylaxis of Intrathecal Morphine Induced Pruritis in Patients Undergoing Caesarean Delivery
Intrathecal morphine is commonly used for pain relief in caesarean delivery. Side effects such as itch (pruritis) and nausea \& vomiting are common and have been shown to be the most common cause for dissatisfaction.
- Trial name
- NCT01283477
- Testing
- ACUPUNCTURE AT LI11
- Where
- Ireland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Letterkenny General Hospital
Lidocaine, Itch
Evaluation of the Effect Induced by Repeated Administration of Topical Local Anaesthetic (EMLA) on Itch
In this experiment, the investigators would like to study if the repeated application of local cuaneous anaesthetic EMLA cream will reduce itch induced by small needles from the plant mucuna pruriens (also known as cowhage) and…
- Trial name
- NCT04076865
- Testing
- EMLA (lidocaine) +Itch (Histamine and cowhage)
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Atopic Dermatitis
A Study to See How Well Lebrikizumab Works in Adults and Adolescents With Moderate Atopic Dermatitis (Eczema) and High Itch Burden
The purpose of this study is to measure how well taking lebrikizumab alone works for participants with fewer places on the body with eczema (atopic dermatitis), but these places may be very itchy.
- Trial name
- ADsolve (NCT07006792)
- Testing
- Lebrikizumab
- Where
- 66 sites in United States, Argentina and 3 more
- Volunteers
- 233 people
- Sponsor
- Eli Lilly and Company
Genital Inflammation, Itching
The Novel Electrolyzed Water Spray Treatment the Genital Itching
The purpose of this study is to test whether spraying the genitalia of patients by use of the novel electrolyzed water spray will produce improvement in the condition of genitalia itching.
- Trial name
- NCT05766930
- Testing
- The novel electrolyzed water spray
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Dove Medical Press Ltd
Allergic Rhinitis, Urticaria
PK Comparisons of Bepotastine Besilate 10 mg and Bepotastine Salicylate 9.64 mg
To compare the relative bioavailability and pharmacokinetic characteristics of a newly developed bepotastine formulation, bepotastine salicylate, with a conventional formulation, bepotastine besilate, in healthy subjects with a…
- Conditions
- Allergic Rhinitis, Urticaria, Pruritus
- Trial name
- NCT01897428
- Testing
- Test-Bepotastine salicylate 9.64 mg, Reference-bepotastine besilate 10 mg
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Uremic Pruritus
A Multi-site Bridging Study of Nalfurafine Hydrochloride Orally Disintegrating Tablet
This is a multisite study to evaluate the efficacy, safety and plasma concentration of Nalfurafine Hydrochloride orally disintegrating tablet in the treatment of refractory pruritus in maintenance hemodialysis patients, and to…
- Trial name
- NCT04728984
- Testing
- Nalfurafine Hydrochloride
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Pruritus
Bioequivalence Study of Nalfurafine Hydrochloride Orally Disintegrating Tablets on Fasting and Fed in Humans
The test formulation of Nalfurafine Hydrochloride Orally Disintegrating Tablets (2.5 μg) is bioequivalent to the reference formulation (Remitch®) in healthy Chinese subjects under fed conditions.
- Trial name
- NCT07478133
- Testing
- Nalfurafine Hydrochloride Orally Disintegrating Tablets, Remitch®
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Healthy Volunteers
The Effect of Low Level Light Therapy on Histamine- and Mucuna Pruriens-induced Pruritus in Healthy Volunteers
This is a prospective, double-blind, randomised, sham-controlled study whose primary aim is to test whether LLLT changes the intensity of itch after histamine application in healthy volunteers compared to sham application.
- Trial name
- NCT05369338
- Testing
- Low Level Light Therapy
- Where
- Austria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Pain, Nausea
Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents
This is an investigator initiated dose finding study designed to determine the optimal dose of naloxone to prevent or minimize the most common side effects induced by opioids, namely itching, nausea, and vomiting.
- Conditions
- Pain, Nausea, Pruritus
- Trial name
- NCT00330343
- Testing
- naloxone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Lichen Sclerosus of Vulva
Nemolizumab for LS
Patients ≥ 18 years of age with Lichen sclerosis (LS)
- Trial name
- NCT07704775
- Testing
- Nemolizumab 30 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Ankle Sprains, Chronic Ankle Instability
Effects of the Elastic Taping on the Chronic Ankle Instability
This study will analyze the effects of an elastic taping application protocol in individuals with chronic ankle instability. One group will perform a protocol with increased tape tension for five weeks while the other group will…
- Conditions
- Ankle Sprains, Chronic Ankle Instability, Athletes Foot
- Trial name
- NCT04568577
- Testing
- Tape with tension, Tape without tension
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Universidade Norte do Paraná
Cesarean Section
Effect of Propofol Administration Time on the Incidence and Severity of Intrathecal Morphine-induced Pruritus in Parturient Undergoing Elective Cesarean Delivaries
Our hypothesis suggests that Administration time of intravenous propofol may affect Pruritus incidence and severity that occur after intrathecal morphine in parturient undergoing elective cesarean section (CS).
- Trial name
- NCT06715657
- Testing
- Morphine intrathecal, propofol
- Volunteers
- 204 people
- Sponsor
- Assiut University
Hemodialysis, Pruritus
Health Belief Model-Based Education for Pruritus and Quality of Life in Hemodialysis Patients
This study evaluates the effect of a Health Belief Model (HBM)-based educational intervention on pruritus severity and pruritus-related quality of life (QoL) in hemodialysis patients.
- Trial name
- NCT07641530
- Testing
- Health Belief Model-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Ege University
Pruritus, Primary Biliary Cholangitis
TH104 for the Treatment of Pruritus in Primary Biliary Cholangitis
A phase 2a, multicenter, randomized, double-blind, placebo-controlled study of TH104 in primary biliary cholangitis (PBC) participants with moderate to severe pruritus.
- Trial name
- NCT06733519
- Testing
- Nalmefene
- Volunteers
- 40 people
- Sponsor
- Tharimmune Inc
Epidermolysis Bullosa
A Neurokinin-1 Receptor Antagonist for the Treatment of Pruritus in Patients With Epidermolysis Bullosa
To determine if Serlopitant (when taken by mouth) is safe and works on itch in patients aged 13 and above with EB.
- Trial name
- NCT03836001
- Testing
- Serlopitant Tablet
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Atopic Dermatitis
Acupressure in Pruritus for Atopic Dermatitis
The purpose of this study is to see if acupressure will be effective at reducing itch in people with atopic dermatitis (AD).
- Trial name
- NCT01074164
- Testing
- Standard-of-care treatment for AD, Accu-patch pellet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Tinea Pedis
Three-Arm Trial of Novel Treatment for Tinea Pedis
This is a three-arm randomized controlled trial to assess the efficacy of an experimental treatment in the treatment of tinea pedis (athlete's foot).
- Trial name
- NCT03135912
- Testing
- Experimental Drug SESC 01, Terbinafine Hydrochloride
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- South End Skin Care
Nasal Stuffiness, Sneezing
Cyanobacteria Allergy in Lake Kineret
People swimming or surfing in lake Kineret , sometimes complain of nasal stuffiness , sneezing and itching .Typically, it happens during or immediately after contact with the lake's water .
- Conditions
- Nasal Stuffiness, Sneezing, Itching
- Trial name
- NCT01693198
- Testing
- Skin test with sterile extracts of different cyanobacteria
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Plaque-type Psoriasis
Judging the Efficacy of Secukinumab in Patients With Psoriasis Using AutoiNjector: a Clinical Trial Evaluating Treatment Results (JUNCTURE)
The purpose of this study was to demonstrate efficacy of autoinjector administered secukinumab at Week 12 based on PASI and IGA response rates versus placebo in subjects with moderate to severe chronic plaque-type psoriasis.
- Trial name
- JUNCTURE (NCT01636687)
- Testing
- Secukinumab 150mg, Secukinumab 300mg
- Where
- 39 sites in United States, Canada and 3 more
- Volunteers
- 182 people
- Sponsor
- Novartis Pharmaceuticals