Clinical trials: Pseudomelia
Lower Limb Amputation Below Knee (Injury)
Effects of Prosthesis Training on Pain, Prosthesis Satisfaction and Ambulatory Status of Lower Limb Amputees
The objective of the study is to assess the effects of prosthesis training with and without phantom exercises on pain, prosthesis satisfaction and ambulatory status of lower limb amputees treated with prosthesis training, phantom…
- Trial name
- NCT06013631
- Testing
- Prosthesis Training, Phantom Exercises
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Lahore
Phantom Limb Pain
Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life
This clinical trial is designed to assess the effectiveness of advanced neuromodulation techniques in reducing phantom limb pain by improving sensory feedback in bionic prostheses.
- Trial name
- NCT06702904
- Testing
- Peripheral Nerve Stimulation, Spinal cord stimulation, Dorsal Root Ganglion Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Pain Management
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation (Experiment 1)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom…
- Trial name
- NCT04750525
- Testing
- BreEStim, EStim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Somatosensory Perception Following Lower Limb Amputation
Spinal Cord Stimulation (SCS) for Amputees
The purpose of this study is to investigate how leg amputee patients can feel sensations with neuromodulation while they are using a prosthetic leg.
- Trial name
- NCT04490382
- Testing
- 32 channel external stimulator
- Sponsor
- Duke University
Amputation, Phantom Limb Pain
Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study
The purpose of this research study is to determine if putting local anesthetic through one or two percutaneous catheters placed next to the nerves that go to an amputated limb will decrease long-term pain in the amputated limb.
- Conditions
- Amputation, Phantom Limb Pain, Stump Pain
- Trial name
- NCT00771862
- Testing
- perineural ropivicaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Diego
Neuropathic Pain, Phantom Pain
Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery
Phantom pain is associated with cortical reorganization after amputation. This phenomenon should not play a role in transsexual women, since the cortical representation of the male sex organs is presumably altered.
- Conditions
- Neuropathic Pain, Phantom Pain, Sex Reassignment Surgery
- Trial name
- NPASRS (NCT04538170)
- Testing
- pain after surgery
- Where
- Germany
- Volunteers
- 423 people
- Sponsor
- University Hospital Tuebingen
Amputation, Phantom Limb Pain
Prosthesis With Sensations
Lower limb amputees suffer complete lack of sensory feedback of current available prostheses, which excludes the central nervous system from the correct sensory-motor integration.
- Conditions
- Amputation, Phantom Limb Pain, Sensory Deficit
- Trial name
- NCT03350061
- Testing
- SENSY
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- Clinical Centre of Serbia
Phantom Limb Pain
Use of Hand Prosthesis With Direct Nerve Stimulation for Treatment of Phantom Limb Pain
Phantom limb pain (PLP) is a frequent consequence of amputation, and it is notoriously difficult to treat. Amputation usually follows traumatic injuries or surgery following vascular diseases, diabetes, osteomyelitis or tumours…
- Trial name
- EPIONE (NCT02796495)
- Testing
- Operation of hand prosthesis with direct nerve stimulation
- Where
- Switzerland
- Sponsor
- Prof. Wassim Raffoul
Phantom Limb Pain
Treatment of Phantom Limb Pain by Intensive Visual Simulation Therapy
Phantom limb pain (PLP) is reported by as much as 80 % of patients following an amputation. There is increasing knowledge of the relation between PLP and maladaptive changes in brain cortical regions.
- Trial name
- NCT06483035
- Testing
- Intensive Visual Simulation (IVS), Usual Care (UC)
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Oslo Metropolitan University
Phantom Limb, Residual Limb Pain
Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation
The purpose of this study is to identify the best treatment sequence and combination of acupuncture points for the treatment of phantom limb or residual limb pain in the traumatic/surgical amputee.
- Conditions
- Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
- Trial name
- NCT00388752
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Walter Reed Army Medical Center
Neuroma, Cryoablation
Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation
atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life.
- Trial name
- AXON-FREEZE (NCT07618689)
- Testing
- Perineuroma Cryoablation, Proximal Nerve Cryoablation
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Amputation, Traumatic
Relationship Between Gait Variability and Sensation
Twenty individuals who were referred to receive physiotherapy will be participants of the study. Participants with lower limb loss will evaluate with the following assessment tools: Demographic datas; age, gender, height, body…
- Trial name
- NCT02934074
- Testing
- No intervention
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee
Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System
This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee, Lower Limb Amputation Knee
- Trial name
- NCT07324109
- Testing
- Vibrotactile sensory feedback
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Median
Phantom Limb Pain
Comparison of Efficacy of Mirror Therapy vs Mental Imagery in Reduction of Phantom Limb Pain in AKAP
Limb amputation results in many types of pain, including localized pain at the stump and projected pain experienced by the patient in the location where the amputated limb used to be, known as phantom limb pain (PLP).
- Trial name
- NCT06428123
- Testing
- Mirror Therapy on present Lower Limb, Mental Imagery on present Lower Limb
- Where
- 2 sites in Pakistan
- Volunteers
- 24 people
- Sponsor
- Superior University
Chronic Pain, Low Back Pain
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
The purpose of this study is to investigate, in two phases: (1) the feasibility and safety of Virtual Embodiment Therapy in treating chronic pain of lower back and upper limbs and (2) the efficacy of Virtual Embodiment Therapy on…
- Conditions
- Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction
- Trial name
- NCT04060875
- Testing
- Karuna Labs Virtual Reality Software
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karuna Labs Inc.
Phantom Limb Pain, Peripheral Vascular Diseases
TENS for Phantom Limb Pain Prevention Following Major Amputation
A growing body of literature indicates that up to 80% of amputees may have phantom limb pain (PLP). The first cause for limb loss is vascular disease. Usually, amputees who suffer from PLP are suboptimal treated.
- Trial name
- NCT02496351
- Testing
- TENS INTERVENTION
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Phantom Limb Pain
Virtual Reality for Phantom Limb Pain
This study will develop a virtual reality-based treatment for phantom limb pain among Veterans and test it against the most established behavioral therapy for phantom limb pain, mirror therapy.
- Trial name
- NCT02784548
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Phantom Limb Pain
Long-term Effects of Transcranial Direct Current Stimulation (tDCS) on Patients With Phantom Limb Pain (PLP)
Phantom limb pain (PLP) refers to pain in a limb that has been amputated or deafferented. Phantom limb pain might be related to brain cortical plastic changes.
- Trial name
- NCT02051959
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Phantom Limb Pain, Neuropathic Pain
Intrathecal Dexmedetomidine and Acute Neuropathic Pain After Lower Limb Amputation
This randomized controlled trial evaluated the effect of adding intrathecal dexmedetomidine (10 µg) to hyperbaric bupivacaine (11 mg) for spinal anesthesia in patients undergoing lower limb amputation.
- Conditions
- Phantom Limb Pain, Neuropathic Pain, Lower Limb Amputation
- Trial name
- DEX-RCT (NCT07565662)
- Testing
- Hyperbaric Bupivacaine plus Saline, Hyperbaric Bupivacaine plus Dexmedetomidine
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Universidad Juárez Autónoma de Tabasco