Clinical trials: Pseudotumor
Idiopathic Intracranial Hypertension (IIH)
Eptinezumab for Chronic Headache in Idiopathic Intracranial Hypertension
The goal of this clinical trial is to learn if eptinezumab can reduce headache frequency and headache-related disability in adults with idiopathic intracranial hypertension (IIH) and chronic headache.
- Trial name
- PRIMA (NCT07645833)
- Testing
- Eptinezumab
- Volunteers
- 96 people
- Sponsor
- Rigmor Højland Jensen
Idiopathic Intracranial Hypertension (IIH), Glymphatic System
Advanced Neuroimaging in Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure leading to symptoms like papilledema, headache, and cognitive dysfunction.
- Trial name
- IIH (NCT06950099)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Jefferson University
Idiopathic Intracranial Hypertension
A Trial to Determine the Efficacy and Safety of Presendin in IIH
Idiopathic intracranial hypertension (IIH) has significant associated morbidity and reduced quality of life. There is a significant risk of visual loss and patients also typically suffer with chronic disabling headaches.
- Trial name
- IIH EVOLVE (NCT05347147)
- Testing
- Presendin
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 14 people
- Sponsor
- Invex Therapeutics Ltd.
Idiopathic Intracranial Hypertension (IIH)
Tirzepatide in Idiopathic Intracranial Hypertension Trial
This will be a randomized, double-blind, parallel, placebo-controlled trial of 60 participants. The primary analysis will be a statistical comparison of the estimates of the mean difference in the 12-month change in intracranial…
- Trial name
- TIIHT (NCT07191873)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Idiopathic Intracranial Hypertension
Evaluating Raised Intracranial Pressure Using MR Elastography
Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of…
- Trial name
- NCT03096743
- Testing
- MR elastography, MRI structural brain imaging, Lumbar puncture
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
ALS (Amyotrophic Lateral Sclerosis), FTD
Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches
Diagnosis of ALS/FTD disease spectrum is challenging because it largely relies on clinical symptoms. Identifying novel biomarkers is essential for a paradigm shift towards a more precise biological-based diagnosis.
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), FTD, Neuropathic, Psychiatric Disorders
- Trial name
- SPECTRALS (NCT06856850)
- Where
- 4 sites in Italy
- Volunteers
- 230 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Idiopathic Intracranial Hypertension
Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.
Assessing the safety and effectiveness of a 11-βhydroxysteroid dehydrogenase type 1 inhibitor (AZD4017), in a placebo controlled trial, in acute idiopathic intracranial hypertension (IIH) IIH is a condition of young, overweight…
- Trial name
- IIH:DT (NCT02017444)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Birmingham
Idiopathic Intracranial Hypertension (IIH)
Venous Sinus Stenting for Idiopathic Intracranial Hypertension Refractory to Medical Therapy
Idiopathic Intracranial Hypertension (IIH) is a disease that affects mainly young people, and is associated with headache and loss of vision.
- Trial name
- VSSIIH (NCT01407809)
- Testing
- Venous Sinus Stenting
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
IIH - Idiopathic Intracranial Hypertension
IIH Intervention: A Clinical Trial Comparing 2 Treatments (Shunts and Stents) Evaluation Of Clinical Effectiveness And Cost Effectiveness
Background and study aims Idiopathic intracranial hypertension (IIH) is a neurological condition characterised by increased pressure inside the skull, called intracranial pressure (ICP).
- Trial name
- Intervention (NCT07440277)
- Testing
- CSF shunt, DVSS
- Where
- 15 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Birmingham
Idiopathic Intracranial Hypertension (IIH)
Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase
This study is aimed at patients suffering from recently discovered intracranial hypertension, caracterized by visual loss, chronic headache and/or tinnitus.
- Trial name
- DIVE IIN EARLY (NCT06919744)
- Testing
- Best medical care, Intervention (stenting)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Pseudotumor Cerebri
Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.
PTC(Pseudotumor cerebri) patients may develop increased Intracranial pressure (ICP) that can produces increased pressure around the distal optic nerve,which is likely followed by venule compression, ischemia, and loss of visual…
- Trial name
- NCT03304314
- Testing
- objective chromatic multifocal pupillometer
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Idiopathic Intracranial Hypertension (IIH)
Dural Venous Sinus Stent in Idiopathic Intracranial Hypertension
This study aims to identify clinical determinants and factors that predict outcome including primary outcome and secondary outcome depending on factors in individual patients with Idiopathic intracranial hypertension treated by…
- Trial name
- NCT06833424
- Testing
- Dural venous sinus stenting
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Retroperitoneal Fibrosis, Autoimmune Pancreatitis
Rituximab in IgG4-RD: A Phase 1-2 Trial
The primary objective of this study is to evaluate the safety and effectiveness of rituximab in IgG4-RD.
- Conditions
- Retroperitoneal Fibrosis, Autoimmune Pancreatitis, Sialadenitis, Pseudotumor
- Trial name
- NCT01584388
- Testing
- Rituximab
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Orbital Ischemic Syndrome, Orbital Pseudotumor
Survey of Patients With Idiopathic Orbital Inflammation Syndrome
The purpose of this study is to characterise the clinical features, histopathology and the treatment outcomes of patients with idiopathic orbital inflammation syndrome.
- Trial name
- SIOI (NCT01443000)
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hydrocephalus, Hydrocephalus in Children
Post Market Clinical Follow-up of CODMAN CERTAS Programmable Valve
Post-Market Clinical Follow-up Registry of Patients with CODMAN CERTAS Plus Programmable Valves.
- Conditions
- Hydrocephalus, Hydrocephalus in Children, NPH (Normal Pressure Hydrocephalus), IIH - Idiopathic Intracranial Hypertension
- Trial name
- NCT05397106
- Testing
- CODMAN CERTAS Plus Programmable Valve
- Where
- 9 sites in Belgium, Germany and 2 more
- Volunteers
- 160 people
- Sponsor
- Integra LifeSciences Corporation
Idiopathic Intracranial Hypertension
MR Lymphatic Imaging in Idiopathic Intracranial Hypertention
In the brain and its borders, blood vessels coexist with lymphatic vessels exclusively in the dura mater, the outermost layer of meninges.
- Trial name
- LYMPHIMAGIIH (NCT05762367)
- Testing
- 3T MRI with Gadobutrol injection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Idiopathic Intracranial Hypertension, Intracranial Pressure Increase
Prospective Ocular Imaging for Intracranial Pressure Evaluation
This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people's eyes - this is a pulse one can see on examination of the back of the eye…
- Conditions
- Idiopathic Intracranial Hypertension, Intracranial Pressure Increase, Spontaneous Venous Pulsations
- Trial name
- POICCP (NCT06855342)
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Pseudotumor Cerebri
Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension
This prospective study will use magnetic resonance imaging of patients with Idiopathic Intracranial Hypertension (IIH), to determine if the common radiological finding of transverse venous sinus stenosis can be reversed with…
- Trial name
- NCT02394067
- Testing
- Radiological Imaging
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Idiopathic Intracranial Hypertension
Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a syndrome characterized by elevated intracranial pressure (ICP) of unknown etiology.
- Trial name
- NCT03963336
- Testing
- LMWH, acetazolamide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Idiopathic Intracranial Hypertension
The Effects of MAP and EtCO2 on Venous Sinus Pressures
The purpose of this study is to further elaborate the role of both arterial blood pressure and end-tidal carbon dioxide concentration on measured venous pressures.
- Trial name
- NCT03867461
- Testing
- Venous Sinus Stenting, Adjustment to end-tidal carbon dioxide concentrations ( 38-40 mmHg range), Adjustment to Mean Arterial Pressure (100-110 mmHg range)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences