Clinical trials: Psychiatric Disorders
Smokeless Tobacco Use, Tobacco Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 1
The extent of toxicity varies considerably across different brands of smokeless tobacco (ST) products and data suggest that greater toxicity may result in greater health risks.
- Trial name
- NCT01067586
- Where
- 3 sites in United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Frailty, Mild Cognitive Impairment
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction.
- Conditions
- Frailty, Mild Cognitive Impairment, Aging
- Trial name
- Mito-Frail (NCT06027554)
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- UConn Health
Sleep Disturbance
Citrus Extract, Sleep and Mental Wellbeing
This is a randomized, double-blind, placebo-controlled, cross-over trial investigating the effects of daily administration of citrus extract on sleep and mental wellbeing.
- Trial name
- NCT06239168
- Testing
- Citrus extract, Maltodextrin
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Depression, Anxiety, Cognitive Impairment
Telehealth Intervention Program for Older Adults
COVID-19 is having profound effects on older adults' due to social isolation measures which may negatively impact individuals' mental and physical health.
- Conditions
- Depression, Anxiety, Cognitive Impairment, Stress
- Trial name
- TIP-OA (NCT04523610)
- Testing
- Telehealth phone calls, Volunteer of TIP-OA Program, Stakeholder of TIP-OA Program
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Parkinson's Disease, Parkinson-Dementia Syndrome
Predictive and Diagnostic Value of Tau and Beta-amyloid Markers in the Dementia of Parkinson's Disease
The PET tracer Fluoro-ethyl-methyl-amino-naphthyl-ethylidene-malononitrile ([F18]-FDDNP) has a specific affinity for lesions containing tau protein and beta-amyloid The study consists of two phases In a first transversal phase, 8…
- Trial name
- NCT02243982
- Testing
- [F18]-FDDNP
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Liver Transplant Disorder
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
- Trial name
- NCT04031924
- Testing
- Assessment of: 1. Functional Capacity 2. Physical Fitness 3. Physical Activity Level 4. Balance 5. Kinesiophobia 6. Psychological Status 7. Fatigue Severity
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Bruxism
mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism
The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants.
- Trial name
- NCT06457646
- Testing
- Genetic polymorphism
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Alzheimer Disease
A Multiple Ascending Dose Study of COR388
The study is a randomized, double-blind, placebo-controlled, multiple ascending dose study to assess the safety and tolerability of ascending repeat doses of COR388 HCl in older healthy male and female subjects and a cohort of…
- Trial name
- NCT03418688
- Testing
- COR388
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Cortexyme Inc.
Symptoms of Depression and Anxiety
Mindfulness Intervention Using Virtual Reality in Older Adults With Symptoms of Anxiety and Depression in Ecuador
The availability of affordable hardware and rapidly growing content that can be freely accessed in the public domain raises the possibility of VR being used across the world globally and, in a very broad range of settings…
- Trial name
- NCT06219642
- Testing
- Mindfulness using virtual reality
- Where
- Ecuador
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidad San Francisco de Quito
Healthy
The Effects of JNJ-42165279 on the Neural Basis of Anxiety Disorders in Healthy Male Volunteers
The purpose of this study is to evaluate the potential efficacy of JNJ-42165279 in treating anxiety disorders through evaluation of brain activation patterns using imaging technology in healthy volunteers.
- Trial name
- NCT01826786
- Testing
- JNJ-42165279 (100 mg)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Eating Disorders
Reducing Eating Disorder Risk Factors
The purpose of this study is to determine whether a web-based program is effective in reducing the incidence of eating disorders in college women who are at high risk for developing an eating disorder.
- Trial name
- NCT00050570
- Testing
- Web-based intervention to reduce eating disorder risk factors
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Stanford University
Child Abuse, Vaginismus
Childhood Sexual Abuse, Vaginismus and Labor Dystocia
The study aims to develop a theoretical model explicating the inter-relationships between Childhood Sexual Abuse (CSA), Partial Vaginismus (PV) and Labor Dystocia (LD), including their associations with Depression (D) as a…
- Conditions
- Child Abuse, Vaginismus, Dystocia, Depression
- Trial name
- CSA-V-LD (NCT01530113)
- Where
- Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Osteoporosis, Cognitive Decline
Vitamin B12 and Folic Acid Supplementation for Preventing Fractures in Elderly People
It is hypothesized that vitamin B12 and folic acid supplementation reduces the number of incident fractures. The proposed study, a randomized placebo-controlled intervention trial, compares daily supplementation with folic acid…
- Trial name
- B-PROOF (NCT00696514)
- Testing
- Vitamin B12, folic acid, Vitamin D3
- Where
- 3 sites in Netherlands
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Alzheimer's Disease
The Locus Coeruleus and Memory
The cause of Alzheimer's disease, the most common form of dementia, remains unknown. Neuropathological studies suggest that a small area in the brainstem, the locus coeruleus, might be the site of the onset of the disease.
- Trial name
- LOCUS (NCT02363504)
- Testing
- 7 Tesla MRI with memory task and non-invasive neurostimulation
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Schizophrenia, Schizoaffective Disorder
NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia
This study will examine brain metabolic and excitatory/inhibitory mechanisms related to cognitive and visual functioning in adults with schizophrenia and healthy control participants.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Impairment, Visual Impairment
- Trial name
- NCT07788755
- Testing
- Perceptual Discrimination Training, Cognitive Control Training
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Dementia, Healthy
Encouraging Cognitive Screenings at African American Churches
This pilot study plans to examine feasibility and outcomes of a culturally/religiously-tailored church-based dementia screening intervention among older adult African American church members and community members who use church…
- Trial name
- NCT05037578
- Testing
- Project Grace
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Anxiety Disorders
Anxiety Disorders in Children - Association With Neurodevelopmental Delay/Disorder
The main objective of the study is to examine the relationship between anxiety disorders and neurodevelopmental disorder/delay in children aged 7- 13 years.
- Trial name
- NCT00553085
- Where
- 2 sites in Norway
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Regionsenter for barn og unges psykiske helse
Dental Anxiety, Impacted Third Molar Tooth
Three Anxiolytic Drugs Used in Third Molar Surgery
This study was to compare the effectiveness of three drugs (Passiflora incarnata, Erythrina mulungum, Midazolam) in controlling anxiety in patients undergoing bilateral extraction of asymptomatic, impacted mandibular third molars.
- Trial name
- NCT02065843
- Testing
- Mulungu, Passiflora incarnata, midazolam
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Bladder Function
Pilot Trial in Sleep Laboratory Setting to Compare the Physiology of Night Time Bladder Function in Subjects With Overactive Bladder (OAB) Versus Subjects That Have Insomnia and Healthy Normal Subjects
This is an observational, physiology pilot study of subjects with overactive bladder, insomnia and normal subjects. No study drug will be given. All subjects will complete a one week sleep diary and a 3-day bladder diary.
- Trial name
- Nocturia Plt 1 (NCT01029015)
- Testing
- cystometry, polysomnography
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Young Adult
Relationship Between Sleep Quality, Sleep Duration, Heart Rate, and Step Number
This study aims to evaluate the relationship among sleep duration, heart rate, number of steps, and sleep quality.
- Trial name
- NCT05829525
- Testing
- Evaluation of sleep quality, sleep duration, heart rate and step count
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
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