Clinical trials: Psychiatric Drugs
Psychiatric Disorder
Using Pharmacogenetics to Identify Patients With Polypharmacy at Risk of Medication Adverse Effects
The Researchers are trying to learn more about how individuals break down and process medications based on their genes. The Researchers want to find out whether subjects will have fewer side effects if they take different…
- Trial name
- NCT03748355
- Testing
- Pharmacogentic Analysis
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Psychiatric/Mood Disorder | Patient, Estrogen Receptor Levels
Validation of [18F]FES for Imaging of Brain Estrogen Receptors
Validation of [18F]-FES for imaging of estrogen receptors in the brain The primary objective of the study is to determine if [18F]-FES Positron Emission Tomography (PET) can be used to quantify the estrogen receptor expression in…
- Conditions
- Psychiatric/Mood Disorder | Patient, Estrogen Receptor Levels, Premenopausal, Postmenopausal
- Trial name
- NCT01842217
- Testing
- FES-PET
- Where
- Netherlands
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Depression, Bipolar Disorder
Neuro-computational Study of Thymic Fluctuations in Mood Disorders
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders".
- Conditions
- Depression, Bipolar Disorder, Recurrent Depression, Mood Disorders
- Trial name
- MOODELING (NCT07033923)
- Testing
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional), Computerized cognitive tests, Daily longitudinal monitoring by mobile MOODELING application
- Where
- 2 sites in France
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Psychotic Disorders
Side Effects of Psychiatric Medications - a Nested Case Control Cohort Historical Prospective Study
The study is designed to fill in the gaps in current knowledge by providing a more inclusive and comprehensive understanding of the potential associations between different psychiatric medications, including antipsychotics (APs)…
- Trial name
- NCT05872555
- Testing
- Psychiatric Drugs
- Where
- Israel
- Volunteers
- 22,777 people, healthy volunteers welcome
- Sponsor
- Mark Weiser, MD, Principal Investigator
Healthy
Simultaneous FMRI and NIRS to Estimate Brain Cerebral Metabolism
The principal advantages of functional magnetic resonance imaging (fMRI) with blood-oxygenation- level-dependent (BOLD) contrast for studying brain function are: non-invasiveness, ubiquitous availability, relatively high…
- Trial name
- NCT01825096
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Psychiatric Disorder
Pilot Study of the Vermont Family Based Approach in Primary Care Pediatrics
This pilot randomized controlled trial of the Vermont Family Based Approach (VFBA) tested the feasibility of the VFBA in primary care pediatrics and its effects on children's and parents' emotional and behavioral problems and…
- Trial name
- NCT04412590
- Testing
- Vermont Family Based Approach, Treatment as Usual
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Obsessive-Compulsive Disorder
Developing Adaptive Treatment Strategies for Children and Adolescents With Obsessive-compulsive Disorder.
Obsessive-compulsive disorder affects approximately 2% of the population, frequently has its onset during childhood or adolescence and is potentially incapacitating.
- Trial name
- SMART (NCT01148316)
- Testing
- fluoxetine, Group cognitive-behavioral therapy
- Where
- Brazil
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Roseli Shavitt
Depression, Treatment Resistant Depression
Computational Psychiatric Approach to Depression
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression.
- Trial name
- NCT04189939
- Testing
- clinical assessments
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Smoking Cessation
Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.
Non-treatment extension to study A3051123, aimed at collecting data on cardiovascular safety for all participants in the A3051123 trial for an additional 28 weeks, allowing for a total of 52 weeks of cardiovascular safety data…
- Trial name
- CATS (NCT01574703)
- Testing
- varenicline tartrate, bupropion hydrochloride, Nicotine Replacement Therapy Patch
- Where
- 134 sites in United States, Argentina and 14 more
- Volunteers
- 4,595 people, healthy volunteers welcome
- Sponsor
- Pfizer
Social Isolation, Loneliness
COVID-19 and Social Isolation and Loneliness Trial
Social isolation and loneliness worsen older peoples' quality of life, risk of dementia, and contributes to 45,000 deaths/year in Canada - as much as smoking.
- Conditions
- Social Isolation, Loneliness, Geriatric
- Trial name
- SIL (NCT05228782)
- Testing
- HOW R U? Intervention
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Depression, Anxiety
Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders
In this study the investigators will seek to improve our understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of mood, substance use, and eating behavior.
- Conditions
- Depression, Anxiety, Eating Disorders, Drug Use Disorders
- Trial name
- NCT02450240
- Testing
- standardized diagnostic assessment, self-report questionnaires, behavioral tasks
- Where
- United States
- Volunteers
- 1,271 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Social Isolation, Loneliness
Intergenerational Program for Social Isolation and Loneliness in Older Adults Discharged From the Emergency Department
Social isolation and loneliness worsens older adults' risk of dementia, quality of life, and death as much as smoking. Older adults are more likely to use emergency services and are also more likely to experience social isolation…
- Conditions
- Social Isolation, Loneliness, Geriatric
- Trial name
- SIL (NCT05998343)
- Testing
- Intergenerational HOW R U?, Same-Generation Peer Support HOW R U?
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Mental Health, Stress Disorders, Post-Traumatic
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
The primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress…
- Conditions
- Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
- Trial name
- NCT00118534
- Testing
- Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 943 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Psychotic Disorders
Family Perspectives:Treatment of Psychiatric Illnesses With Atypical Long Acting Injectable Antipsychotic Medication
Patients who have schizophrenia, schizoaffective disorder, a psychotic disorder, and are being treated with a medication called Risperidone Long Acting Injectable medication or another antipsychotic medication are candidates for…
- Trial name
- NCT00287027
- Testing
- Risperdal Long Acting Injectable Antipsychotic Medication
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Alliance on Mental Illness New Hampshire
Akathisia
Akathisia (Restless Legs Syndrome) in People With Schizophrenia and Mental Retardation
Akathisia is a movement disorder that is often a side effect of certain psychiatric drugs. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace.
- Trial name
- NCT00065286
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Epidemiologic Data of Some Synthetic Cannibinoids Toxicity in Patients Presenting at Assiut University Hospital, Psychiatric Hospital of Ministry of Health), Proportion of Acute and Chronic Abusers of Synthetic Cannibinoids Among Cases of Illicit Drugs Abuser in Studied Sites
Acute and Chronic Toxicity of Some Synthetic Cannabinoids in Assiut Psychiatric Hospitals
Synthetic cannabinoids (SCs) are new human-made mind-altering chemicals which are similar to chemicals found in the marijuana plant; they are recent to be used recreationally, especially by young adults.
- Trial name
- NCT03866941
- Testing
- causes of abuse synthetic cannibinoids
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Burnout, Professional, Anxiety
Occupational Distress in Doctors: The Effect of an Induction Programme
Background: Over 39% of approximately 3,000 doctors (The British Medical Association quarterly survey, 2015) admitted to frequently feeling drained, exhausted, overloaded, tired, low and lacking energy.
- Conditions
- Burnout, Professional, Anxiety, Grief, Adaptation, Psychological
- Trial name
- NCT02838290
- Testing
- Induction, Control group
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Birkbeck, University of London
Pregnant Women, Psychotropic Drugs
National Pregnancy Registry for Psychiatric Medications
The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications such as antidepressants, ADHD medications, sedative hypnotics, and atypical antipsychotics that many…
- Trial name
- NCT01246765
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Quality of Life
Milestones of Adjustment Post-Psychosis
This nested design clinical outcome study of psychiatric case manager education on disease state, psychopharmacology of schizophrenia, relapse, motivational interviewing, and the process of psychological adjustment post-psychosis…
- Conditions
- Schizophrenia, Quality of Life, Adjustment, Psychological, Medication Adherence
- Trial name
- MAPP (NCT01192594)
- Testing
- Training in all modules including MAPP Recovery Model, Training in all modules except MAPP Recovery Model
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Yale University
Adverse Mental/Physical Effects of Low Dose S. Tortuosum.
Safety Study of the Effect of Scelectium Tortuosum (as Zembrin®)in Aged Normals
Phosphodiesterase is a candidate for the Rx \& prevention of cognitive and psychotic disorders. Since caffeine targets primarily PDE4(Phosphodiesterase subtype 4), caffeine analogs have been developed to mimic the actions of…
- Trial name
- NCT01805518
- Testing
- Scelectium Tortuosum
- Where
- Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Woodbury, Michel, M.D.