Clinical trials: Psychiatric Illness
Dementia
Paradoxical Lucidity in Severe End-Stage Dementia
Cognitive decline in dementia is considered irreversible, however episodes of paradoxical lucidity (PL) in severe dementia suggest other mechanisms may be in play.
- Trial name
- NCT05234866
- Where
- United States
- Volunteers
- 520 people
- Sponsor
- NYU Langone Health
Schizophrenia, Parkinson's Disease
PET Scanning in Parkinson s Disease
This is an in vivo positron emission tomography (PET) study of regional cerebral dopamine and blood flow in normal volunteers, persons with Parkinson s disease (both familial and sporadic), and those with schizophrenia spectrum…
- Trial name
- NCT00024622
- Testing
- O-15 Water, 18F-Fluoro-L-dopa
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Treatment Resistant Depression
Open-Label Safety Study of AXS-05 in Subjects With Depression
An open-label, long-term, safety study of AXS-05 in patients with major depressive disorder (MDD), including treatment resistant depression.
- Conditions
- Major Depressive Disorder, Treatment Resistant Depression, Depression
- Trial name
- NCT04039022
- Testing
- AXS-05 (dextromethorphan and bupropion) oral tablets
- Where
- 51 sites in United States
- Volunteers
- 876 people
- Sponsor
- Axsome Therapeutics, Inc.
HIV, Mental Health
Stepped Care for Youth Living With HIV
Optimizing the HIV Treatment Continuum with a Stepped Care Model for Youth Living with HIV (YLH) aims to achieve viral suppression among YLH.
- Conditions
- HIV, Mental Health, Illicit Substance Use, Sexually Transmitted Infections (STI)
- Trial name
- NCT03109431
- Testing
- Level 1, Level 2, Level 3
- Where
- 2 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Insomnia
Digitally-Assisted Brief Behavioral Treatment for Insomnia in College Students
The study is a single-blind study, parallel randomized controlled trial method. The purpose of this study was to explore the effectiveness of the mobile version of Application based Brief Behavioral Treatment for Insomnia…
- Trial name
- NCT07114302
- Testing
- Interactive E-book BBTI Group, BBTI-APP Group
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Dementia
SettleIN - Adjustment to Care in Dementia: An Intervention Feasibility Study v0.1
Admission into a care home for people with dementia has been linked with both positive and negative psychological outcomes for both the resident and their carers.
- Trial name
- NCT02682472
- Testing
- SettleIN - Adjustment to care programme
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Cognitive Impairment, Dementia
Older Adults With Cognitive Impairment Doing Sit to Stands, Walking in Transitional Care Programs: A Feasibility Study
The goal of this intervention study is to test the effects of a nurse-led mobility intervention (known as the OASIS Walking Intervention (Older Adults performing Sit to Stands and Walking Intervention)) in older adults with…
- Conditions
- Cognitive Impairment, Dementia, Delirium, Functional Decline
- Trial name
- OASIS (NCT06150339)
- Testing
- OASIS Walking Intervention
- Where
- 2 sites in Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Aortic Valve Replacement, Aortic Stenosis
TAVI Protocol - Paravertebral Block Study
Trans-apical aortic valve replacement is a new treatment for severe aortic stenosis. It is offered to elderly patients with medical problems that would markedly increase the risk of conventional cardiac surgery.
- Trial name
- TAVI PVB (NCT01404975)
- Testing
- Thoracic paravertebral block (PVB)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Insomnia, Sleep Disturbance
Sleeping For Two: Trial for CBT for Insomnia in Pregnancy
Cognitive-behavioural therapy for insomnia (CBT-I) has been shown to be an effective treatment for insomnia in multiple populations, including women during pregnancy and postpartum.
- Trial name
- NCT03918057
- Testing
- Cognitive Behavioural Therapy for Insomnia, Active Control
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Calgary
Erectile Dysfunction
Atherogenic Index of Plasma and Tadalafil Response in Erectile Dysfunction
This prospective single-center observational cohort study examined whether baseline atherogenic index of plasma (AIP), calculated from routine triglyceride and high-density lipoprotein cholesterol measurements, was associated…
- Trial name
- NCT07479901
- Testing
- tadalafil
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people
- Sponsor
- Taksim Egitim ve Arastirma Hastanesi
Schizophrenia
Reboxetine Adjuvant Therapy for the Treatment of Schizophrenia
30 patients will randomly be selected and will be administered either reboxetine or a placebo. changes in cognition and behavior will be assessed by computer tests and scales during a six week study period.
- Trial name
- NCT00409201
- Testing
- reboxetine adjuvant therapy
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Abarbanel Mental Health Center
Family Members, Anxiety
Perioperative Family Updates Reduce Anxiety and Improve Satisfaction
This study was a randomized control trial conducted to determine if frequent, standardized updates affect anxiety and satisfaction of family members.
- Conditions
- Family Members, Anxiety, Satisfaction
- Trial name
- NCT04330612
- Testing
- Perioperative Updates
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Compulsory Psychiatric Care Act, Psychosis
Psychological Treatment in Psychiatric Inpatient Care
This study aims to investigate the effect of a brief psychotherapeutic treatment intervention based on ACT, aimed specifically at the vulnerable group of patients in psychiatric 24-hour care treated according to LPT.
- Conditions
- Compulsory Psychiatric Care Act, Psychosis, Acceptance & Commitment Therapy, Psychiatric Hospitalization
- Trial name
- NCT06012981
- Testing
- ACT
- Where
- Sweden
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Attention Deficit Hyperactivity Disorder
A Study of Pediatric Participants With Attention Deficit/Hyperactivity Disorder
The primary purpose of the study is to assess long-term safety and tolerability of Edivoxetine in pediatric participants with attention deficit hyperactive disorder (ADHD).
- Trial name
- NCT00965419
- Testing
- Edivoxetine
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 267 people
- Sponsor
- Eli Lilly and Company
Rumination
Effects of tDCS Combined With VR on Anxious Ruminations in Healthy Subjects With a Vulnerability to Rumination
This study proposes: to evaluate 1) whether the combination of virtual reality (VR) and active tDCS provides better rumination attenuation than the combination of VR and tDCS placebo 2) the acceptability and experiential…
- Trial name
- REVISTIM-XX (NCT03915041)
- Testing
- VR + active brain stimulation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cigarette Smoking, Veterans
Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment
Veterans with substance use disorders smoke at extraordinarily high rates and have high rates of smoking-related death and disease.
- Trial name
- Co-STOP (NCT07809854)
- Testing
- Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Alzheimer Disease
ADvance II Study: DBS-f in Patients With Mild Alzheimer's Disease
The primary efficacy objective of this study is to test the hypothesis that DBS-f stimulation (ON) will slow cognitive and functional progression of AD, as compared to no stimulation (OFF), by measuring baseline…
- Trial name
- NCT03622905
- Testing
- DBS-f On, DBS Off
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 74 people
- Sponsor
- Functional Neuromodulation Ltd
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged…
- Trial name
- WellderlyBrain (NCT07646054)
- Testing
- Education
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Scripps Translational Science Institute
Anxiety, Medication-refractory Focal-onset Epilepsy
The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety
The purpose of this study is to evaluate the feasibility, safety, and effects on anxiety of high intensity focused ultrasound ablation (FUSA) in patients suffering from treatment-refractory focal epilepsy and anxiety.
- Trial name
- NCT05032105
- Testing
- Magnetic Resonance Imaging-guided Focused Ultrasound Ablation (MRgFUSA)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ohio State University
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