Clinical trials: Psychiatric Illness
Major Depressive Disorder
Randomized, Double-Blind, Placebo Controlled Study of Vilazodone's Efficacy, Safety, and Biomarkers of Response in Major Depressive Disorder (MDD)
This randomized, double-blind, placebo-controlled, multicenter, 8-week, clinical trial is designed to assess the efficacy and safety of vilazodone and to evaluate genetic biomarkers of treatment response associated with…
- Trial name
- NCT00683592
- Testing
- vilazodone
- Where
- 9 sites in United States
- Volunteers
- 481 people
- Sponsor
- Forest Laboratories
Cardiac Diseases Requiring Surgery
Investigating the Related Factors and Outcome of Kinesiophobia and the Effects of Multidimensional Interventions in Cardiac Surgery Patients
The primary objective of this two-year research project is to investigate the status of activity fear, its related factors, and prognosis in cardiac surgery patients in the first year.
- Trial name
- NCT06625892
- Testing
- the multidimensional interventions
- Where
- Taiwan
- Volunteers
- 245 people
- Sponsor
- Ai-Ling Chang
Alzheimer's Disease
ATP in Alzheimer Disease
To Check whether systemic treatment with ATP alters the profile of cerebral metabolism in patients with Alzheimer's disease using MRS techniques (Magnetic Resonance Spectroscopy) and adjust the infusion (minimum effective dose)…
- Trial name
- NCT02279511
- Testing
- ADENOSINE TRIPHOSPHATE
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Sara Varea
Opioid Use Disorder, Neonatal Abstinence Syndrome
RESPECT-PLUS: Services for Infants With Prenatal Opiate Exposure
The impact of parental opioid use disorder and other substance use exposure on child welfare and the healthcare system is undeniable.
- Conditions
- Opioid Use Disorder, Neonatal Abstinence Syndrome, Child Development, Child Abuse
- Trial name
- RESPECT-Plus (NCT02334111)
- Testing
- RESPECT-Plus
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Medical Center
Parkinson Disease, REM Sleep Behavior Disorder
Implementing a National Biobank of PD With WGS and Functional Assessment of Polygenic Inheritance by iPSC Technology
The genetic complexity and heterogeneity of the sporadic forms of Parkinson's disease (PD) are posing a formidable challenge to disentangle their direct molecular causes.
- Trial name
- NCT05721911
- Testing
- whole genome sequencing
- Where
- Italy
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Intravenous Ketamine for Treatment-Resistant Depression
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA…
- Trial name
- G2K (NCT06668571)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Postpartum Depression
Sleep, Oxytocin and Reward Processing in Women in the Postpartum Phase
During and after pregnancy, a woman's body and brain undergo significant changes that help her adapt to caregiving and emotional needs.
- Trial name
- NCT06711809
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Insomnia, Sleep-Disordered Breathing
CPAP vs ASV for Insomnia
The study will determine which of two different types of positive airway pressure (PAP therapy) modes are more effective in reducing sleep breathing events in chronic insomnia patients and in decreasing insomnia severity.
- Trial name
- P2P (NCT02365064)
- Testing
- AirCurve 10 ASV
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- ResMed
Sleep Disorder
Postoperative Sleep Quality and Pain of Patients After Video-Assisted Thoracoscopic Surgery
The goal of this clinical trial is to to explore the effect of perioperative transcutaneous acupoint acupuncture and moxibustion stimulation on sleep quality and postoperative chronic pain in patients undergoing thoracoscopic…
- Trial name
- PSQ (NCT06633432)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Depressive Disorder
Combining Antidepressants and Attention Bias Modification in Depression
Background: Major depressive disorder (MDD) is a highly prevalent psychiatric condition associated with significant disability, mortality and economic burden.
- Trial name
- DEPTREAT (NCT05503966)
- Testing
- Attentional Bias Modification
- Where
- Norway
- Volunteers
- 246 people
- Sponsor
- University of Oslo
Mental Health, PTSD
Further Development and Initial Testing of RESTORE in Frontline Workers
There is considerable need for psychological intervention targeting stressor-related mental health symptoms related to COVID-19.
- Conditions
- Mental Health, PTSD, Anxiety, Depressive Symptoms
- Trial name
- RESTORE (NCT04873622)
- Testing
- RESTORE: Recovering from Extreme Stressors Through Online Resources and E-health
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Anxiety, Exercises Therapy
Progressive Relaxation Exercises on Anxiety Levels
The research will be conducted to determine the effect of progressive relaxation exercises on the anxiety level of patients who have had total knee replacement surgery.
- Conditions
- Anxiety, Exercises Therapy, Total Knee Replacement Surgery
- Trial name
- NCT06676202
- Testing
- Progressive Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Amnesia
Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase
The transient global amnesia, in which the memory disorder is massive, transient and pure, offers a unique model for exploring episodic memory.
- Trial name
- ICTUS (NCT02010853)
- Testing
- IRMf
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Major Depressive Disorder, Post-Traumatic Stress Disorder
Examination of Glutamate and mGluR5 in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT02727972
- Testing
- Cognitive Testing, MRI, PET
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Uterine Cervical Dysplasia
Music and Colposcopy in Women With Cervical Dysplasia.
To assess the effect of music during colposcopy on women´s anxiety.
- Trial name
- NCT03005795
- Testing
- Headphones, No Headphones
- Where
- 2 sites in Germany
- Volunteers
- 205 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Nocturnal Enuresis
Treatment of Monosymptomatic Nocturnal Enuresis
A prospective randomized trial to study the effect of spinal magnetic stimulation versus posterior tibial neuromodulation in the treatment of monosymptomatic nocturnal enuresis.
- Trial name
- NCT05306639
- Testing
- Rehabilitation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Huntington's Disease
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease
Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT).
- Trial name
- ChANGE HD (NCT01860339)
- Where
- 6 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Peggy C Nopoulos
Neurodevelopmental Disorder (Diagnosis)
Expanding NGS Data with Optical Genome Mapping (OGM)
Over 50% of pediatric neurological and neurodevelopmental disorders lack a molecular diagnosis after standard DNA sequencing and molecular karyotyping.
- Trial name
- OGM (NCT06851377)
- Testing
- Optical Genome Mapping (OGM) and Whole Genome Sequencing (WGS), Trascriptome analysis
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Eugenio Medea
Attention Deficit Hyperactivity Disorder
Efficacy of GXR as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD
This study looks to examine whether or not INTUNIV extended release can help children aged 6-12 years diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) in improving Executive Function when added to their usual care…
- Trial name
- NCT01985581
- Testing
- Guanfacine extended release, Stimulant therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- JPM van Stralen Medicine Professional
Psychosomatic Symptoms, Temporomandibular Disorder (TMD)
Psychosomatic Symptoms in Patients With Myofascial Pain and Temporomandibular Joint Dysfunction
Temporomandibular joint disorder poses an intricate etiology. Biomechanical, neuromuscular and psychosocial factors may contribute to the disorder among which psychological and psychosocial disturbances have shown strong direct…
- Trial name
- Psychosomatic (NCT07385781)
- Testing
- Casr
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bahria University
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