Clinical trials: Psychogenic Seizures
Convulsion, Non-Epileptic, Conversion Disorder
Treatment Trial for Psychogenic Nonepileptic Seizures
The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined treatment (CBT-ip + sertraline)…
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NEST-T_1 (NCT00835627)
- Testing
- sertraline, CBT-ip, Combined (sertraline + CBT-ip)
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Dissociative Seizures
Cognitive Behavioural Therapy in Dissociative Seizures
The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater…
- Trial name
- NCT00688727
- Testing
- CBT, Standard Care
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Conversion Disorder, Psychogenic Movement Disorder
Embodied Virtual Reality Therapy for Functional Neurological Symptom/ Conversion Disorder
The purpose of this study is to design and test the safety and feasibility of virtual reality technologies and experiences of egocentric avatar embodiment in the application of physical and cognitive behavior therapy in…
- Conditions
- Conversion Disorder, Psychogenic Movement Disorder, Functional Movement Disorder, Functional Neurological Disorder
- Trial name
- VR4FND (NCT02764476)
- Testing
- Embodied Virtual Reality Therapy, Virtual reality
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Seizures, Seizure Disorder
Modulating Movement Intention Via Cortical Stimulation
The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies.
- Conditions
- Seizures, Seizure Disorder, Psychogenic Movement Disorder
- Trial name
- NCT03233399
- Testing
- rTMS of left or right angular gyrus (AG) or frontal cortex (FC), Anodal tDCS of left or right AG or FC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Psychogenic Nonepileptic Seizures, Dissociative Seizures
ADIE-FS - Aligning Dimensions of Interoceptive Experience in Patients With Functional Seizures
Functional seizures are common and harmful. They look like epileptic seizures but are not caused by the excess electrical discharges in the brain that arise in epilepsy.
- Conditions
- Psychogenic Nonepileptic Seizures, Dissociative Seizures, Psychogenic Pseudoseizure, Functional Neurological Disorder
- Trial name
- ADIE-FS (NCT06105996)
- Testing
- Interoceptive training
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Psychogenic Movement Disorders, Non-epileptic Seizures
Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure
This study will explore how the mind and the brain work to cause movement symptoms or seizures in people who do not have a recognized neurological or medical disorder.
- Trial name
- NCT00255411
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT) R33 Phase
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- ReACT (NCT06007053)
- Testing
- ReACT, Supportive Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Epilepsy, Dissociative Seizures
Stress and Seizures - Can a Brief Self-help Book Help?
Background: Epilepsy and nonepileptic attack disorder (NEAD) are chronic conditions that cause many patients to experience a great degree of stress in their everyday lives.
- Trial name
- NCT02465047
- Testing
- Self-help booklet
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Functional Neurological Disorder, Dissociative Seizures
The Feasibility and Acceptability of an Online Yoga Program for People With Functional Neurological Disorders
This is a feasibility study to see if it is acceptable and helpful for people living with a functional neurological disorder to receive online group yoga sessions to improve their wellbeing
- Conditions
- Functional Neurological Disorder, Dissociative Seizures, Psychogenic Seizure, Non-Epileptic Seizure
- Trial name
- YOGA-FUND (NCT07077603)
- Testing
- A12 week, twice weekly, small group, online yoga program
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Psychogenic Nonepileptic Seizures, Psilocybin
Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures
Psychogenic non-epileptic seizures (PNES) are functional paroxysmal motor disorders that may be clinically suggestive of epilepsy but are not associated with the electroencephysiological and electroencephalographic changes of…
- Trial name
- CRIPSY (NCT06647056)
- Testing
- Psilocybin, MRI
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Epilepsy, Dissociative Seizures
Mainz Epilepsy Registry
Prospective longitudinal observational registry study of all patients with epilepsy treated in the Mainz Comprehensive Epilepsy and Sleep Medicine Center with the focus on the course of the disease and quality of life.
- Conditions
- Epilepsy, Dissociative Seizures, Status Epilepticus
- Trial name
- MAINZ-EPIREG (NCT05267405)
- Testing
- no interventions, only observation
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- Johannes Gutenberg University Mainz
Functional Seizures, Convulsion, Non-Epileptic
A Multi-site Feasibility Clinical Trial of Retraining and Control Therapy (ReACT), a Mind and Body Treatment for Pediatric Functional Seizures
The purpose of this study is to assess the feasibility of conducting a future fully powered multi-site efficacy Randomized Controlled Trial (RCT) comparing two treatments for pediatric functional seizures (FS).
- Trial name
- NCT05819268
- Testing
- ReACT, CATCH-IT
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Psychogenic Non-Epileptic Seizure, Depression
Project UPLIFT for Psychogenic Non-Epileptic Seizures
Developed by researchers from the Centers for Disease Control and Prevention (CDC), Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a group telephone program designed to improve depression for…
- Conditions
- Psychogenic Non-Epileptic Seizure, Depression, Non-Epileptic Seizure, Psychogenic Seizure
- Trial name
- PNES (NCT03329703)
- Testing
- Project UPLIFT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Psychogenic Seizure, Epilepsy, Temporal Lobe
Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback
This study investigates whether the sense of agency is sensitive to self-regulation by means of EEG-based neurofeedback. During neurofeedback, the brain activity in response to a motor task is recorded in real-time and displayed…
- Conditions
- Psychogenic Seizure, Epilepsy, Temporal Lobe, Health, Subjective
- Trial name
- NF-Agency (NCT05214833)
- Testing
- Real Neurofeedback
- Where
- Switzerland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Nonepileptic Seizures
Treating Non-epileptic Seizures Using Magnetic Brain Stimulation
The purpose of this study is to investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) - a form of non-invasive brain stimulation - to decrease the frequency of psychogenic non-epileptic seizure…
- Trial name
- NCT02796924
- Testing
- MagStim Rapid2 Transcranial Magnetic Simulation
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Convulsion, Nonepileptic, Conversion Disorder
Comparing Different Treatments in Reducing Dissociative Seizure Occurrence
The study will test the hypothesis that Cognitive Behavioural Therapy plus Standardised Medical Care (SMC) will have greater clinical and cost effectiveness than SMC alone in treating adult patients with dissociative seizures…
- Conditions
- Convulsion, Nonepileptic, Conversion Disorder, Dissociative Disorder
- Trial name
- CODES (NCT02325544)
- Testing
- Cognitive Behavioral Therapy, Standardized Medical Care
- Where
- 40 sites in United Kingdom
- Volunteers
- 368 people
- Sponsor
- King's College London
Psychogenic Nonepileptic Seizures (PNESs), Post Traumatic Stress Disorder PTSD
Treatment for Psychogenic Nonepileptic Seizures and Post-traumatic Stress Disorder Using Prolonged Exposure Therapy (PE) or Psychoeducation for PNES
An outpatient randomized controlled clinical trial conducted at the Northeast Regional Epilepsy Group's PNES Program, involving mental health clinicians certified in PE and trained in administering PsychoEd.
- Trial name
- PNES (NCT07344766)
- Testing
- imaginal and in vivo exposure, psychoeducation for psychogenic nonepileptic seizures
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Northeast Regional Epilepsy Group
Epilepsy, Motor Partial, Psychogenic Seizures
Detecting PNES With Single-channel sEMG
This is a prospective, comparative, multicenter study of subjects being admitted for standard of care therapy in Epilepsy Monitoring Units in the Veteran's Affair (VA) Medical Centers.
- Trial name
- NCT03313362
- Testing
- SPEAC System, video EEG
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- Brain Sentinel
Psychogenic Nonepileptic Seizures
Video-EEG Features of Adult Patients With Psychogenic Nonepileptic Seizures
This completed retrospective observational study evaluated adult patients diagnosed with psychogenic nonepileptic seizures (PNES) who underwent video-EEG monitoring.
- Trial name
- NCT07521761
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Convulsion, Non-Epileptic
Automated Identification of Psychogenic Nonepileptic Seizures
A retrospective validation study of a post-processing method intended to identify psychogenic nonepileptic seizures
- Trial name
- NCT03013348
- Testing
- Brain Sentinel's sEMG Post-processing algorithm
- Volunteers
- 104 people
- Sponsor
- Brain Sentinel