Clinical trials: Psychological Disorder
Mental Disorders
Efficacy of the Recovery Workbook as a Psychoeducational Tool for Facilitating Recovery
The present study will determine if Spaniol and colleague's (1994) Recovery Workbook group intervention is an effective clinical tool to move a person with SMI along in their journey of recovery.
- Trial name
- NCT00375167
- Testing
- Recovery Workbook Training (psychoeducational training), ACT as usual
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Queen's University
Attention Deficit Hyperactivity Disorder
Brain Dopamine Function in Adults With ADHD
The purpose of the study is to investigate the functional state of dopamine cells and the dopamine transporter in ADHD subjects and controls to assess the effects of chronic methylphenidate treatment on dopamine cell function and…
- Trial name
- Brookhaven (NCT00580814)
- Testing
- Experimental: methylphenidate treatment
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Alzheimer's Disease
A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild to Moderate Alzheimer's Disease
This is a study to evaluate the safety, tolerability and blood levels of PF-03654746 in subjects will mild to moderate Alzheimer's disease.
- Trial name
- NCT01028911
- Testing
- PF-03654746
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Pfizer
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Antisocial Behavior, Aggression
The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
This study investigates the relationship between prefrontal cortex activity and antisocial and aggressive behavior, and risk factors for such behavior.
- Trial name
- NCT02674516
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Schizophrenia
Switching Medication to Treat Schizophrenia
This study will evaluate the effectiveness of switching medications in decreasing schizophrenia symptoms in individuals who are currently taking an antipsychotic medication for the treatment of schizophrenia.
- Trial name
- NCT00044655
- Testing
- Risperidone, Olanzapine, Ziprasidone
- Volunteers
- 219 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Attention Deficit Hyperactivity Disorder
Atomoxetine Asian Study in Adult Subjects With Attention-Deficit/Hyperactivity Disorder (ADHD)
The primary objective of this clinical study is to assess overall safety and tolerability as measured by discontinuation rate due to adverse events in doses up to 120 mg/day in relation to global clinical studies in adult…
- Trial name
- NCT00636818
- Testing
- Atomoxetine
- Where
- 11 sites in China, South Korea and 1 more
- Volunteers
- 45 people
- Sponsor
- Eli Lilly and Company
Attention-Deficit Hyperactivity Disorder
Pharmacokinetics of HLD200 in Children and Adolescents With ADHD
This study was designed to assess the pharmacokinetic effects of a single dose of HLD200 (methylphenidate hydrochloride) in children and adolescents with ADHD.
- Trial name
- NCT01907360
- Testing
- HLD200 (methylphenidate hydrochloride)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Ironshore Pharmaceuticals and Development, Inc
Smith-Lemli-Opitz Syndrome
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
This study will evaluate the safety and effectiveness of simvastatin in treating children with Smith-Lemli-Opitz syndrome (SLOS).
- Trial name
- NCT00064792
- Testing
- Simvastatin Susp., OraPlus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Forbes Porter, M.D.
Insomnia, Depression
Reducing Suicidal Ideation Through Insomnia Treatment
Epidemiologic reports have linked insomnia to suicidal ideation and suicide death. However, no studies have determined whether treating insomnia decreases the risk of suicidality.
- Conditions
- Insomnia, Depression, Suicidal Ideation
- Trial name
- REST-IT (NCT01689909)
- Testing
- Zolpidem-CR
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Augusta University
Mental Disorders
Integrated Care & Patient Navigators for Latinos With Serious Mental Illness
The health care needs of people with serious mental illness are exacerbated by ethnic health disparities. Latinos with serious mental illness show significant health problems compared to other ethnic groups.
- Trial name
- NCT02469714
- Testing
- Peer Navigator Intervention
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Illinois Institute of Technology
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Mindfulness for Parents of Children With Autism Spectrum Disorder Autism Spectrum Disorder
The current study examines the efficacy of Mindfulness-Based Stress Reduction (MBSR) to reduce parenting stress, lessen parental reactivity and negativity, and decrease child externalizing behaviors among families of children…
- Trial name
- ASD (NCT03459625)
- Testing
- Mindfulness-Based Stress Reduction (MSBR), Psychoeducational Support Group (PE)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Loma Linda University
Treatment Resistant Depression
KET-RO Plus RO DBT for Treatment Resistant Depression
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine combined with RO DBT in young adults with Treatment-Resistant Depression (TRD).
- Trial name
- KET-RO (NCT06138691)
- Testing
- Ketamine Infusion plus RO DBT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Alzheimer's Disease
Long Term Extension Study Evaluating Safety, Tolerability And Immunogenicity Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's Disease
The purpose of this long term extension study is to assess safety, tolerability and immunogenicity of ACC-001 with QS-21 adjuvant in Japanese subjects with mild to moderate AD who were randomized in the preceding P2 double blind…
- Trial name
- NCT01238991
- Testing
- ACC-001
- Where
- 11 sites in Japan
- Volunteers
- 53 people
- Sponsor
- Pfizer
Schizophrenia, Schizo Affective Disorder
Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia
This application seeks to determine if neurophysiological metrics of memantine (MEM)-enhanced early auditory information processing (EAIP) in schizophrenia (SZ) mediate gains in auditory processing fidelity (APF) and auditory…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder, Healthy
- Trial name
- NCT03860597
- Testing
- Memantine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Psoriasis
The Quality of Life Study in Psoriasis Patients After Ustekinumab Treatment
This study aims to see if patient quality of life can be approved after treatment with an injectable medication called ustekinumab for the treatment of generalized psoriasis.
- Trial name
- NCT01511315
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Francisco
Anxiety
Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone
Background: Benzodiazepine, a common premedicant, suppresses endogenous melatonin levels and thus paradoxically increases episodes of arousal during sleep and thus causes restlessness and hangs over effects.
- Trial name
- NCT01486615
- Testing
- meloset (melatonin), stresnil ( melatonin and alprazolam), (alprax) alprazolam
- Where
- 2 sites in Nepal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Attention Deficit Hyperactivity Disorder
Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD
The aim of this study is to examine the mechanisms by which stimulant medications reduce symptoms in patients with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01415440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cognitive Impairment
Preoperative Cognitive Screening of Elderly Surgical Patients
The objectives of this pilot study are: 1. to determine whether a short cognitive test battery administered in the preadmission test center can be used to cognitively stratify elderly patients presenting for elective surgical…
- Trial name
- NCT01826825
- Testing
- Cognitive Screen, Mini-Cog
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
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