Clinical trials: Psychological Disorders
Anxiety, Pain
The Effect of Virtual Reality Glasse on Pain and Anxiety During Episiotomy Repair
Episiotomy is one of the common surgical operations that can cause anxiety in women and have side effects such as pain. Nerve blockades with analgesic effects such as lidocaine used during episiotomy repair or the use of…
- Conditions
- Anxiety, Pain, Episiotomy Wound, Midwifery
- Trial name
- NCT05198908
- Testing
- VR group, Skin to skin group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Bipolar Disorder
Tryptophan Depletion in Acute Mania
Serotonin (5-HT) is important in mood regulation and is believed to play a major role in the pathophysiology of major depression (MD).
- Trial name
- NCT00192725
- Testing
- rapid tryptophan depletion
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Sleep, Sleep Deprivation
Sleep Duration Required to Restore Performance During Chronic Sleep Restriction
The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase.
- Conditions
- Sleep, Sleep Deprivation, Insufficient Sleep Syndrome
- Trial name
- NCT01581125
- Testing
- Sleep:wake 1, Sleep:wake 2
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Schizophrenia, Schizoaffective Disorder
Get Moving and Get Well - Pilot Study
Individuals with serious mental illness have greater morbidity from physical illness and mortality than the general population, but tend not to initiate or sustain engagement in health promotion interventions.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- GMGWP (NCT01884025)
- Testing
- Get Moving and Get Well, Health and Humor Class
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Treatment Resistant Depression
Effects of TBS on 5-HT1A Receptor Binding
Background: Theta-burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS) holds promise as an effective treatment for treatment resistant depression (TRD).
- Trial name
- NCT02810717
- Testing
- theta-burst stimulation using a MagPro X1000
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Rupert Lanzenberger
Dementia, Infection, Bacterial
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias
This is a 52-month study (8 months preparation; 36 months to conduct the trial; 8 months data analyses and manuscript preparation) of a cluster randomized controlled trial (RCT) of an intervention to improve infection management…
- Trial name
- TRAIN-AD (NCT03244917)
- Testing
- TRAIN-AD
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- Hebrew SeniorLife
Cognition Disorders
Impact of Glasses for Vision Problems on Cognitive Function in Rural Older Adults
The aim of this project is to explore whether vision correction can effectively slow cognitive decline in older adults. The primary question it seeks to answer is: Can providing free near and/or distance vision correction glasses…
- Trial name
- CLEVER (NCT06836440)
- Testing
- Free Prescription Glasses
- Where
- China
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Yuju Wu
Amyloid, Amyloid Cardiomyopathy
18F-florbetaben PET-CT to Non-invasively Diagnose Cardiac AL Amyloidosis
Amyloidoses are systemic or acquired disorders characterized by the deposition in the extracellular spaces of amyloid fibers formed by proteins codified by mutated genes or non-mutated but misfolded proteins.
- Trial name
- PETAL (NCT06048601)
- Testing
- 18F-florbetaben PET/CT
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Alzheimer Disease
A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability and efficacy of GV-971 in mild to moderate Alzheimer's disease.
- Trial name
- GREEN MEMORY (NCT04520412)
- Testing
- GV-971
- Where
- 171 sites in United States, Australia and 8 more
- Volunteers
- 2,046 people
- Sponsor
- Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
Suicidal Ideation, Major Depressive Disorder
Anti-suicidal Effects of Buprenorphine In Depressed Individuals
This study aims to examine the effect of low-dose buprenorphine as an add-on to treatment-as-usual for suicidal ideation in individuals with major depression, and investigate the functional brain activity related to its potential…
- Trial name
- NCT05427981
- Testing
- Belbuca Buccal Product
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Substance Use Disorders
Strategies to Enhance Recruitment and Retention of Black Individuals Into Clinical Trials for Substance Use Disorders
The overall goal of this research project will be to obtain feedback from consumers to help develop a manual called I-DREM (Innovative Development of Research Engagement Manual).
- Trial name
- I-DREM (NCT05124119)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Texas Southwestern Medical Center
PTSD, Post-traumatic Stress Disorder
Neurofeedback Effectiveness Trial in PTSD
This study is an effectiveness trial investigating neurofeedback (NFB) in adults with PTSD (Post-Traumatic Stress Disorder). Participants will be randomly assigned to one of two treatment conditions - i) NFB, or ii) wait list.
- Conditions
- PTSD, Post-traumatic Stress Disorder, Cognitive Dysfunction, Cognitive Deficit
- Trial name
- NCT04654130
- Testing
- Neurofeedback
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Anxiety Disorders, Social Anxiety Disorder
The Effectiveness of Transdiagnostic CBT Protocol on Anxiety Disorders
The transdiagnostic approach argues that the common features are needed to be taken into account [e.g. distress intolerance (DI), intolerance of uncertainty (IU), worry)] underlying emotional disorders rather than evaluating them…
- Conditions
- Anxiety Disorders, Social Anxiety Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT06422728
- Testing
- Unified Protocol for Anxiety Disorders, Client-centered Supportive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ibn Haldun University
Dementia, Stroke
Facilitating Caregiver Adaptation to Patient Institutionalization
This study will assess the effects of an intervention targeting family caregivers who recently placed a relative in a long-term care facility because of cognitive and/or physical disability.
- Conditions
- Dementia, Stroke, Heart Disease
- Trial name
- FACTS (NCT01194128)
- Testing
- Psychoeducational Support, Information only control group
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Nicotine Dependence, Substance Use Disorders
Healthy People Initiative (HPI)
Addictions do not occur in isolation. Tackling addictions requires addressing social determinants such as isolation, homelessness, marginalization, and unemployment.
- Trial name
- HPI (NCT03506867)
- Testing
- Life skills, training, education and work/volunteer opportunities, Usual Care
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Mental Health Wellness 1
Health Promotion on Young Adults With High Risk Disability for Mental Health
1. The positive outcomes reported by participants in experimental group after two weeks of interventions will be significantly better than before interventions. 2.
- Trial name
- HPMI (NCT01740167)
- Testing
- health promotion lifestyle program
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Schizophrenia
Study Evaluating the Efficacy and Safety of WID-RGC20(Cariprazine) in Patients With Schizophrenia
This Study is a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center, Fixed-Dose, Phase 3 Clinical Trial Evaluating the Efficacy and Safety of WID-RGC20 3 mg/day and 6 mg/day in Patients with Acute Psychotic…
- Trial name
- NCT05168007
- Testing
- WID-RGC20(Cariprazine) 3mg/day, WID-RGC20(Cariprazine) 6mg/day
- Where
- South Korea
- Volunteers
- 342 people
- Sponsor
- Whanin Pharmaceutical Company
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Autism Spectrum Disorder
Sibling-Mediated Intervention on Literacy and Reciprocity for Children With Autism
Given the increasing prevalence of autism spectrum disorder (ASD), estimated to be 1 in 68 in the United States alone, ASD has become one of the fastest-growing pediatric concerns.
- Trial name
- NCT05098392
- Testing
- Sibling-mediated intervention
- Where
- 3 sites in United States, China
- Volunteers
- 8 people
- Sponsor
- Arizona State University
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