Clinical trials: Psychological Disorders
Opioid Use Disorder
Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study
This study proposes to examine the safety, tolerability, and pharmacokinetics (PK) of NYX-783 50 mg and 150 mg versus Placebo (PBO) in combination with acute Oxycodone 15 mg and 30 mg in an inpatient randomized, cross-over study…
- Trial name
- NCT05447286
- Testing
- NYX-783, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer Disease
Therapeutic Evaluation of Low-dose IL-2-based Immunomodulatory Approach in Patients With Early AD
Study aims at evaluating the therapeutic efficacy and safety of low-dose IL-2 immunomodulatory treatment in patients with early AD, in a phase II, randomized, double blind, placebo-controlled phase II clinical trial.
- Trial name
- IL-2-AD (NCT05468073)
- Testing
- Proleukin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier St Anne
Caffeine, Sleep Deprivation
Real-Time Caffeine Optimization During Total Sleep Deprivation
Sleep deprivation (SD) has a powerful degrading effect on cognitive performance, particularly psychomotor vigilance (PV) and reaction time. Caffeine is well known to be an effective countermeasure to the effects of SD.
- Conditions
- Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
- Trial name
- NCT04399083
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Depression, Anxiety
Online Psychological Group Interventions
The aim is to assess the effectiveness of online group CBT for reducing symptoms of depression and anxiety among university students.
- Trial name
- NCT05016154
- Testing
- Online Group CBT intervention, SilverCloud guided, SilverCloud Unguided
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Stellenbosch
Sleep Disorders, Autism Spectrum Disorder
Verification of the Efficacy of NPC-15 for Sleep Disorders of Children With Autism Spectrum Disorders
The purpose of this study is to verify the efficacy of NPC-15 (melatonin 1 mg/d or 4 mg/d) versus placebo to sleep latency with electronic sleep diaries.
- Trial name
- NPC-15-5 (NCT02757066)
- Testing
- NPC-15 Granules Lower Dose, NPC-15 Granules Higher Dose
- Volunteers
- 196 people
- Sponsor
- Nobelpharma
Magnetic Resonance Imaging, Alzheimer's Disease
Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease
The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate.
- Conditions
- Magnetic Resonance Imaging, Alzheimer's Disease, Dementia, Adult Children
- Trial name
- PC (NCT00478166)
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer's Disease
Chronic Electrical Stimulation of Hypothalamus/Fornix in Alzheimer's Disease
Alzheimer's Disease (AD) is the most common cause of dementia for which no treatment has shown consistent efficacy to stop or slow down the disease.
- Trial name
- NCT00888056
- Testing
- Bilateral chronic electrical stimulation of the hypothalamus/fornix
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Preclinical Alzheimer's Disease
Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease
The purpose of this study is to assess the safety and efficacy of gemfibrozil in modulating microRNA-107 levels for the prevention of Alzheimer's disease in subjects with intact cognition and mild cognitive impairment
- Trial name
- NCT02045056
- Testing
- Gemfibrozil
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gregory Jicha, 323-5550
Autism, Food Allergies
An Autism Study Using Nambudripad's Food Allergy Elimination Treatments
1. We hypothesize that children in the experimental group will show a significant improvement over the control group as all food allergens groups and some other relevant allergenic substances are desensitized in a systematic way…
- Trial name
- NCT00247156
- Testing
- Acupressure treatments and NAET treatments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Nambudripad's Allergy Research Foundation
Treatment-Resistant Depression
Focal Electrically Administered Seizure Therapy for the Treatment of Depression
The purpose of this study is to determine the efficacy and any possible side effects of focal electrically administered seizure therapy (FEAST) as a treatment intervention for patients with recurrent and treatment resistant…
- Trial name
- FEAST (NCT02462551)
- Testing
- Focal Electrically Administered Seizure Therapy
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- Ziad Nahas
Schizophrenia, Schizoaffective Disorder
Cognitive Remediation for Coordinated Specialty Care
Cognitive remediation (CR) is an evidence-based behavioral skills intervention that targets the cognitive processes underlying functioning in everyday life.
- Trial name
- NCT03930251
- Testing
- Clinic-Based Cognitive Remediation, Partial-Remote Cognitive Remediation
- Where
- 9 sites in United States
- Volunteers
- 117 people
- Sponsor
- New York State Psychiatric Institute
Substance Use Disorder
OPAL: "Opiates and PhArmacoLogy"
The aim of this study is to determine the current prevalence of co-addictions, including problem/pathological gambling, in patients receiving Opiate Substitution Treatment (OST), and to then compare patients receiving OST with or…
- Trial name
- OPAL (NCT01847729)
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- Nantes University Hospital
Allograft, Post-allograft Relapse
RElapse After Allograft: Link Between LoCus of Control and QualiTy of Life
Allogeneic hematopoietic transplantation (AlloHCT) is a robust therapeutic that is used as a consolidation strategy in a number of haematological cancers. It provides durable responses as compared to chemotherapy alone.
- Trial name
- REACT (NCT05258929)
- Testing
- Data collection (Prior and planned treatments, allograft)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Psychotic Disorders, Schizophrenia Spectrum Disorders
Feasibility, Acceptability, and Preliminary Efficacy of Yoga-based Group Intervention for Outpatients With Schizophrenia Spectrum Disorders
A three-arm pilot rater-blinded randomized controlled trial is conducted, comprising Yoga-based Group Intervention (YoGI + TAU) as the experimental condition, a strength and flexibility training (SFT + TAU) group, and treatment…
- Trial name
- YOGIA (NCT07455929)
- Testing
- Yoga-based Group Intervention (YoGI) and treatment as usual (TAU), Strength and Flexibility Training (SFT) and TAU
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Schizophrenia, Schizoaffective Disorder
Video as a Tool to Improve Insight in Schizophrenia
The deficit of awareness of pathology (or insight) is a common symptom in patients with schizophrenia and has a negative impact on the prognosis of the disease.
- Trial name
- VideoInsight (NCT02664129)
- Testing
- Video self-observation, Non Self video observation
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Tourette Syndrome
Behavioral Therapy for Tourette Syndrome
This research is being done to determine whether a home-based behavioral therapy can be successfully used to treat tics in children with Tourette syndrome (TS).
- Trial name
- BTTS:HBTA (NCT03019731)
- Testing
- Therapist-directed Behavioral Therapy, Home-based DVD Therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Coronavirus Disease 2019
Detection Rate of SARS-CoV-2 in Male Genitourinary System and Its Impact on Male Reproductive Health.
This study will evaluate the changes in sexual function, reproductive function and mental health of male patients discharged from the hospital with COVID-19, and the impact of SARS-CoV-2 on male reproductive health and mental…
- Trial name
- COVID-19 (NCT04388631)
- Testing
- Coronavirus Disease 2019
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Major Depressive Disorder
Efficacy of Vortioxetine on Cognitive Dysfunction in Patients With Partial or Full Remission of Major Depressive Disorder
To assess the efficacy of vortioxetine (10 to 20 mg/day) as adjunctive treatment to stable selective serotonin reuptake inhibitor (SSRI) dose versus stable SSRI monotherapy on cognitive performance (focusing on the aspect…
- Trial name
- NCT02279953
- Testing
- Vortioxetine 10-20 mg, SSRI
- Where
- 17 sites in Estonia, Finland and 3 more
- Volunteers
- 151 people
- Sponsor
- H. Lundbeck A/S
Depression
Examination of a Soy-Based Supplement for Major Depression
The purpose of this study is to find out if the soy-based dietary supplement Novasoy (Registered Trademark) is effective for the short-term treatment of clinical depression.
- Trial name
- NCT00042380
- Testing
- Novasoy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Mental Health (NIMH)
Cannabis Dependence, Anxiety Disorders
Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders
This project tests the feasibility and utility of a novel, integrated approach to treatment of patients with cannabis use disorder (CUD) and anxiety disorders.
- Conditions
- Cannabis Dependence, Anxiety Disorders, Cannabis Use Disorder, Cannabis Abuse
- Trial name
- NCT01875796
- Testing
- Cognitive-Behavioral Therapy, Motivation Enhancement Therapy, Integrated Cannabis and Anxiety Reduction Treatment
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Louisiana State University and A&M College
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