Clinical trials: Psychology, Social
Kidney Transplant Rejection, Kidney Transplant Failure
Protocol Biopsies in High-risk Renal Transplant Recipients
The present study aims to evaluate the usefulness of protocol biopsies in a cohort of renal transplant patients of high immunological risk for graft injury and loss.
- Conditions
- Kidney Transplant Rejection, Kidney Transplant Failure, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- NCT04154267
- Testing
- Percutaneous renal biopsy.
- Where
- Brazil
- Volunteers
- 119 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Skin Graft (Allograft) Rejection, Skin Graft Complications
The Effect of Platelet Rich Plasma on Pain at Skin Graft Donor Sites
The purpose of this study is to compare post-operative skin graft donor site pain between those treated with standard wound care vs PRP. Secondarily the study is designed to compare time to complete donor site healing.
- Conditions
- Skin Graft (Allograft) Rejection, Skin Graft Complications, Skin Graft Detachment, PRP
- Trial name
- NCT03937765
- Testing
- PRP harvest and preparation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1)
The objective of this trial is to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in single lung transplant recipients with…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-1 (NCT03657342)
- Testing
- Liposomal Cyclosporine A, standard of care
- Where
- 39 sites in United States, Belgium and 5 more
- Volunteers
- 62 people
- Sponsor
- Zambon SpA
Fertility Issues, Childhood Cancer
Fertility and Temporality in Pediatric Oncology
Background: When a cancer is diagnosed in a child, the urgency is to take therapeutic actions. Children and their families face the reality of cancer and the reality of the treatments that, in addition to be overwhelming, might…
- Conditions
- Fertility Issues, Childhood Cancer, Psychology, Social
- Trial name
- FERTITOP (NCT05048771)
- Testing
- Questionnaire
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Acceptance Processes, Rejection, Psychology
Efficacy of a Virtual Reality-Enhanced Gagne's Instructional Model
Gagne's conditions of instructional learning theory, it presumed that several learning levels was exist that require different instruction types, and external and internal environments, commonly referred to as "conditions of…
- Trial name
- VR-gagne (NCT06139471)
- Testing
- Virtual Reality-Enhanced Gagne's Instructional Model
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Eating Disorders, Maladaptive Personality Trait
MICBT for Non-underweight Adults With Eating Disorders
Eating disorders (ED) are severe but treatable conditions, but there are large margin for improvements in terms of efficacy and adherence.
- Conditions
- Eating Disorders, Maladaptive Personality Trait, Emotion Regulation, Personality
- Trial name
- MICBT-ED (NCT05503745)
- Testing
- CBT-F+MIT, CBT-E
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Centro Trattamento Integrato: Disturbi Alimentari e Obesita
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
Cf-DNA Assay During Treatment of Acute Rejection
The objective of this study is to determine whether cell-free DNA (cf-DNA) measurement can be used as a biomarker for successful treatment of an acute rejection (AR) episode after kidney transplantation.
- Conditions
- Kidney Transplant Failure and Rejection, Kidney Transplant; Complications, Kidney Transplant Rejection, Transplant; Complication, Rejection
- Trial name
- NCT04019353
- Testing
- cf-DNA Collection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Evidence of Liver Transplantation, Hyperglycemia
Study of Glycemic Control on Liver Transplantation Outcomes
Many but not all studies have shown improvement in morbidity and mortality with intensive glycemic management postoperatively. In this study, the investigators propose to determine whether improved glycemic control using…
- Conditions
- Evidence of Liver Transplantation, Hyperglycemia, Rejection
- Trial name
- NCT01211730
- Testing
- Insulin
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Northwestern University
Testosterone's Effects on Threat Perception/Response
Study on the Effects of Exogenous Testosterone on Threat Perception and Behavioral Avoidance
The study aims to establish a clear causal link between testosterone and threat perception and behavioral responses to threat. Namely, the study focuses whether high levels of testosterone will cause an individual to exhibit…
- Trial name
- NCT01408498
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Kidney Transplant Failure and Rejection
Home Based Monitoring of Kidney Transplants Utilizing Capillary Microsamples
Renal transplant recipients are followed as out patients at the transplant center for about 8 weeks after surgery. Between 1-2 weeks after surgery, 50 standard immunological patients will be randomized (1:1) to either follow…
- Trial name
- HBM-KTx (NCT04369612)
- Testing
- Standard follow-up, Home-based monitoring
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Liver Diseases, Alcoholic, Alcohol-Related Disorders
Cohort/Ethics Study of Patients With Severe Alcoholic Hepatitis Undergoing Early Liver Transplantation
The purpose of this study is to develop a clinical understanding of early liver transplantation (ELT) for patients with severe alcoholic hepatitis (SAH) and identify the public's opinion regarding this practice.
- Conditions
- Liver Diseases, Alcoholic, Alcohol-Related Disorders, Transplant; Failure, Liver, Transplant; Complication, Rejection
- Trial name
- NCT04234139
- Testing
- liver transplant
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Implant or Graft; Rejection
Implant Placement in Horizontally Deficient Maxillary Aesthetic Zone With Simultaneous Soft Tissue Augmentation
Tooth extraction in maxillary esthetic zone is accomplished with great dimensional changes of the alveolar ridge, different procedures have been tested to compensate these dimensional alteration, such as Hard bone augmentation…
- Trial name
- NCT05274256
- Testing
- implant placement with simultaneous soft tissue augmentation
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cairo University
Transplant; Complication, Rejection
Mechanistic Evaluation of Treatments for Acute Antibody-Mediated Rejection of the Kidney Transplant
The best treatment for kidney failure is a kidney transplant, but a transplanted kidney only works for about 10 to 15 years on average.
- Trial name
- MOT-AMR (NCT04496037)
- Testing
- Rituximab
- Volunteers
- 170 people
- Sponsor
- Imperial College London
Kidney Transplant Failure and Rejection, Immunosuppression-related Infectious Disease
Tacrolimus Pharmacokinetic Subpopulations
This prospective study will investigate the concentrations of tacrolimus metabolites (M-I and M-III) over the four first years post-transplantation.
- Trial name
- TIPS (NCT04526431)
- Testing
- Dosage Forms Oral
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Grenoble
Immunosuppression
Fibroscan to Guide Post Transplant Immunosuppression Minimization
Following Liver transplantation, recipients remain on life long immunosuppression. Prolonged exposure to immunosuppression is associated with side effects and complications including kidney dysfunction, diabetes, heart disease…
- Trial name
- NCT07206277
- Testing
- Immunosuppression reduction
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Social Psychology
Oxytocin and the Social Brain
It has long been established that interpersonal relationships can have a profound impact on health and well-being. Yet, the investigators are still learning about the complex biological processes that contribute to positive…
- Trial name
- NCT02393456
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lung Transplant Failure and Rejection, Lung Transplant Infection
Liquid biopsiEs fOr luNg AllogRaft Damage classificatiOn - LEONARDO
LTx has the shortest survival of all solid organ transplants. The complex and time-demanding diagnostics of allograft dysfunction are a significant reason for this.
- Trial name
- LEONARDO (NCT06679257)
- Testing
- cell-free dNA
- Where
- Sweden
- Volunteers
- 146 people
- Sponsor
- Jesper Magnusson
Heart Transplantation, Kidney Transplantation
Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival
Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection.
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation, Lung Transplantation
- Trial name
- NCT00531921
- Where
- 5 sites in United States
- Volunteers
- 313 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Chronic Disease
The Psychological, Social, and Economic Impacts of COVID-19
A dynamic analytical tool is being implemented to monitor the health, psychosocial and economic impacts of the COVID-19 pandemic as the crisis unfolds.
- Conditions
- COVID-19, Chronic Disease, Psychiatric Disorder, Cardiovascular Diseases
- Trial name
- C19Survey (NCT04369690)
- Where
- 10 sites in Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ottawa