Clinical trials: Psychomotor Agitation
Schizophrenia
Staccato Loxapine in Agitation (Proof of Concept)
The purpose of this study is to assess efficacy and safety of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients.
- Trial name
- NCT00369577
- Testing
- Inhaled Loxapine 5 mg, Inhaled Loxapine 10 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Restlessness, Pain
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia
Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for short-term postoperative sedation and analgesia.It can also reduce the stress response without respiratory depression.
- Trial name
- NCT01517932
- Testing
- dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Fang Luo
Psychomotor Agitation, Schizophrenia
A Study of Staccato Loxapine (ADASUVE®) for Inhalation
Phase 3 safety and efficacy study of Staccato Loxapine in the treatment of acute agitation in schizophrenic or bipolar disorder patients.
- Conditions
- Psychomotor Agitation, Schizophrenia, Bipolar Disorder
- Trial name
- NCT04148963
- Testing
- Inhaled loxapine
- Volunteers
- 150 people
- Sponsor
- Lee's Pharmaceutical Limited
Agitation, Dementia
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)
A study to determine the safety and efficacy of BXCL501 dosing for episodes of agitation associated with dementia when they occur (given as needed [PRN]), for a maximum of 28 doses within a 12-week treatment period.
- Trial name
- NCT05271552
- Testing
- BXCL501
- Where
- 11 sites in United States
- Volunteers
- 151 people
- Sponsor
- BioXcel Therapeutics Inc
Alzheimer's Disease, Psychosis
Treatment of Psychosis and Agitation in Alzheimer's Disease
Clinically, many patients with AD show no response or minimal response to antipsychotics for symptoms of agitation/aggression or psychosis, or they have intolerable side effects on these medications.
- Conditions
- Alzheimer's Disease, Psychosis, Agitation
- Trial name
- NCT02129348
- Testing
- Lithium
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- New York State Psychiatric Institute
Hygiene
Reducing Visitors- and Personnel-associated Infection Risk on Perinatal Care Station
The rate of infectious diseases (amnioninfection syndrome (AIS), fetal inflammatory response syndrome (FIRS), early-onset neonatal sepsis (EONS)) in perinatal care / neonatology is steadily rising in Germany.
- Trial name
- NCT03032887
- Testing
- voice prompts, agitation
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Agitation
Music and Essential Oil in Agitation
The study aims to assess the effect of using music and essential oil on agitation in mechanically ventilated patients. Listening to classical relaxation music, and inhalation to bergamot oil will be used in this study.
- Trial name
- NCT04722614
- Testing
- Music, Essential oil, Control
- Where
- 2 sites in Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Agitated; State, Acute Reaction to Stress
Dexmedetomidine Combined With Hydromorphone in Tonsillectomy and Adenoidectomy
Tonsillectomy and adenoidectomy is one of the most common pediatric surgeries, and agitation and severe postoperative pain have been considered a very common complications.
- Trial name
- NCT03760809
- Testing
- Dexmedetomidine 0.5μg／kg, Dexmedetomidine 1μg／kg
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Dementia, Agitation
Virtual Reality to Advance Dementia Care and Quality of Life
The goal of this feasibility clinical trial is to learn whether supervised virtual reality (VR) sessions can be safely and practically provided to adults aged 55 years and older with moderate-to-severe dementia who experience…
- Conditions
- Dementia, Agitation, Behavioural and Psychological Symptoms of Dementia, Major Neurocognitive Disorder
- Trial name
- VR-Care (NCT07893678)
- Testing
- Supervised Virtual Reality Sessions
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dementia, Behavior Problems
Treatment Routes for Exploring Agitation
The purpose of this study is to examine the efficacy of non-pharmacological ways to treat agitated behaviors in nursing home residents with dementia.
- Trial name
- TREA (NCT00820859)
- Testing
- TREA (Treatment Routes for Exploring Agitation)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Aging (NIA)
Alcohol Abuse, Alcoholism
Consequences of At-risk Alcohol Consumption in ICU Patients
At-risk drinking is known to cause a high incidence of alcohol withdrawal syndrome which has a high impact on morbidity and mortality.
- Trial name
- NCT03565016
- Testing
- no interventional study
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Delirium, Agitation
The Effectiveness of Acupuncture for Complications in Critically Ill Patients
Introduction: Intensive care unit (ICU) is a special department in the health care facility. Although with high development of modern medicine nowadays, the average mortality rate in ICU is still around 7 to 20 %.
- Conditions
- Delirium, Agitation, Arrhythmia, Feeding Intolerance
- Trial name
- NCT04950738
- Testing
- pess tack acupuncture
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Agitation, Emergence, Post Operative Pain
Effect of Caudal Nalbuphine on Postoperative Emergence Agitation in Pediatrics Undergoing Infra-umbilical Surgeries
Effect of caudal nalbuphine on postoperative emergence agitation in pediatrics undergoing infra-umbilical surgeries and pain assessment
- Trial name
- NCT05245721
- Testing
- Nalbuphine, Bupivacain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dementia
Characteristics of Patients With Dementia Who Are Screaming in Nursing Homes
Patients with dementia develop behavioral problems over time. Among these, the investigators object screams or cries or disruptives vocalizations. Their cause is multifactorial and their management difficult in nursing homes.
- Trial name
- NCT04760015
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Schizophrenia, Schizoaffective Disorder
Study on the Safety and Effectiveness of Risperidone Treatment of Acute Psychotic Patients
The purpose of this study was to evaluate the safety of risperidone treatment in acute psychotic patients that require an admission into emergency department.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- NCT00515489
- Testing
- Risperidone
- Volunteers
- 1,882 people
- Sponsor
- Janssen-Cilag, S.A.
Akathisia
Prophylaxis Against Metoclopramide-Induced Akathisia
ABSTRACT Study Objective: To compare the effects of midazolam and diphenhydramine for the prevention of metoclopramide induced akathisia.
- Trial name
- NCT01051271
- Testing
- midazolam
- Volunteers
- 225 people
- Sponsor
- Pamukkale University
Alzheimer's Disease
Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease
This study evaluates the effect of ORM-12741 on agitation/aggression symptoms in Alzheimer's disease. Two thirds of the patients will receive ORM-12741 and one third will receive placebo.
- Trial name
- Nebula (NCT02471196)
- Testing
- ORM-12741
- Where
- Finland
- Volunteers
- 308 people
- Sponsor
- Orion Corporation, Orion Pharma
Agitation, Anxiety
Learning Oriented Physiotherapy - a New Approach
Outpatients that suffer from different anxiety disorders may have physical ailments that negatively affect daily life functioning and quality of life.
- Conditions
- Agitation, Anxiety, Dizziness, Pain
- Trial name
- LOF (NCT02194036)
- Testing
- Learning Oriented Physiotherapy, Widely Recognized Psychiatric Treatment
- Where
- 3 sites in Norway
- Volunteers
- 81 people
- Sponsor
- Helse Nord-Trøndelag HF
Respiratory Failure With Hypercapnia
Listen to a Audio Book
This study investigates how listening to audiobooks affects agitation scores and respiratory parameters (like breathing rate, depth, and oxygen saturation) in patients receiving non-invasive mechanical ventilation (NIMV) for…
- Trial name
- NCT06944093
- Testing
- audio book
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Emergence From Anesthesia, Mechanical Ventilation
Controlled Ventilation During Anesthetic Emergence
Absolutely - for a ClinicalTrials.gov-style Brief Summary, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during…
- Trial name
- NCT07853547
- Testing
- Controlled/Full-Support Mechanical Ventilation During Emergence
- Where
- Saudi Arabia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City