Clinical trials: Psychophysiology
Stress, Acute Stress
Neurophysiological and Autonomic Responses to Acute Physical and Emotional Stress: An EEG Study
This study aims to investigate neurophysiological, autonomic, and subjective responses to different acute physical and emotional stress-inducing conditions using a within-subject repeated-measures design.
- Trial name
- NCT07781670
- Testing
- Cold Pressor Test, Negative Autobiographical Memory Recall, Affective Picture-Viewing Task
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Fibromyalgia
Healing Through Affective Self-Awareness in Fibromyalgia: a Randomized Controlled Trial
The investigators are studying whether a brief three-session mind-body workshop helps people with fibromyalgia. The investigators hypothesize that this workshop will significantly improve pain and other symptoms, compared to…
- Trial name
- NCT00437411
- Testing
- Affective Self-Awareness workshop
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Mike Hsu
Post Traumatic Stress Disorder
Effect of TMS on PTSD Biomarkers
The study will (1) assess feasibility of a TMS treatment in an underserved population; (2) determine if this TMS treatment protocol improves PTSD symptoms and biological markers of PTSD such as brain functioning and startle…
- Trial name
- NCT04563078
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Stress Disorder
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
This study will assess the effectiveness of taking propranolol soon after a traumatizing incident in reducing the incidence and severity of posttraumatic stress disorder in acutely traumatized individuals.
- Trial name
- NCT00158262
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mitochondrial Diseases
Mitochondrial Stress, Brain Imaging, and Epigenetics
The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A>G mitochondrial DNA (mtDNA)…
- Trial name
- MiSBIE (NCT04831424)
- Testing
- Trier social stress test
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Columbia University
PMDD, Stress
Stress & Premenstrual Symptoms Study
This study that aims to evaluate the psychophysiology of premenstrual mood disorders (PMDs) at baseline and after treatment with sertraline. Participants will include women with PMDs and healthy female controls.
- Conditions
- PMDD, Stress, Mood
- Trial name
- NCT02777372
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bipolar Disorder
Clozapine vs. Placebo in Treatment-Refractory Bipolar Disorder in Children and Adolescents
The purpose of this study is to determine the safety and effectiveness of clozapine in children and adolescents with treatment resistant bipolar disorder.
- Trial name
- NCT00036582
- Testing
- Clozapine
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- National Institute of Mental Health (NIMH)
Misophonia Treatment
Instructed Cognitive Reappraisal in Reducing Affective, Behavioral and Psychophysiological Symptoms of Misophonia
Misophonia is a disorder causing intense reactions to specific sounds, disrupting daily life. Current treatments lack evidence-based support.
- Trial name
- NCT06372405
- Testing
- Cognitive reappraisal, Schultz Autogenic Training
- Where
- Poland
- Volunteers
- 108 people
- Sponsor
- University of Warsaw, Poland
PostTraumatic Stress Disorder
PTSD Among Victims of Sexual Abuse and Changes in Structural and Functional Brain Connectivity
The goal of this study is to identify the early modifications in fronto-temporal connectivity in female victims who developed PTSD, compared to female victims who did not develop the disorder, and to healthy control females.
- Trial name
- COPTSD (NCT01405495)
- Testing
- MRI-based techniques (sMRI, fMRI, DTI, ASL)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Chronic Pain
Patient Activation to Address Chronic Pain and Opioid Management in Primary Care
Will a primary care-based behavioral intervention for patient activation and engagement and self-management, for patients with chronic pain who are taking opioid pain medication, result in better patient outcomes than Usual Care?
- Trial name
- NCT02290223
- Testing
- Behavioral Based Treatment Model
- Where
- 2 sites in United States
- Volunteers
- 376 people
- Sponsor
- Kaiser Permanente
Mood Disorder
The Role of Emotion in the Development of Psychopathology
The dysregulated experience and expression of emotion is implicated in psychiatric disorders associated both with externalizing problems (aggressive, antisocial behaviors) and internalizing problems (anxiety, depression).
- Trial name
- NCT00001654
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Psychophysiology, Visually Impaired Persons
Study of Effectiveness of Audio Guided Deep Breathing on Improving the Quality of Life of Physically Disabled Group
Diaphragmatic breathing brings different advantages to improve physical and mental health but it could be difficult for the physically disabled group to follow the practice by themselves especially those with vision impairment.
- Conditions
- Psychophysiology, Visually Impaired Persons, Physiological Phenomena, Psychological Stress
- Trial name
- NCT05396027
- Testing
- Audio-guided deep breathing
- Where
- Malaysia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Functional Voice Disorder, Psychogenic Voice Disorder
Autonomic Dysfunction in Functional Dysphonia
The first objective of this research project is to compare the occurrence and frequency of symptoms and/or disorders related to autonomic dysfunction in patients with functional dysphonia with gender- and age-matched vocally…
- Conditions
- Functional Voice Disorder, Psychogenic Voice Disorder, Muscle Tension Dysphonia
- Trial name
- NCT06100601
- Testing
- ANS regulation therapy, conventional voice therapy (CVT), ANS regulation therapy + CVT
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Ghent
Post-traumatic Stress Disorder
Adjunctive Biofeedback Intervention for Operation Iraqi Freedom/Operation Enduring Freedom (OIF-OEF) Post Traumatic Stress Disorder (PTSD)
Objective: The aims are to examine the feasibility and acceptability of a handheld biofeedback device as an adjunct treatment for Post Traumatic Stress Disorder (PTSD) and to estimate its clinical effect size.
- Trial name
- ABIOP (NCT00920036)
- Testing
- StressEraser
- Volunteers
- 8 people
- Sponsor
- Central Arkansas Veterans Healthcare System
Prosocial Behavior, Forgiveness
From the Heart: Comparing the Effects of Spiritual and Secular Meditation on Psychophysiology, Cognition, Mental Health, and Social Functioning in Healthy Adults
The purpose of this study is to investigate and compare the effects of Christian and Islamic heart-centred spiritual meditation to mindfulness meditation and waitlist control conditions, respectively, in healthy adults.
- Conditions
- Prosocial Behavior, Forgiveness, Empathy, Pain
- Trial name
- NCT06136676
- Testing
- Arm 1 - Heart-Centred Spiritual Meditation: Christian contemplation, Arm 1 - Heart-Centred Spiritual Meditation: Islamic contemplation, Arm 2 - Action Control: Mindfulness Meditation
- Where
- 2 sites in India
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Coventry University
Personality Disorders, Borderline Personality Disorder
Evaluation of AIT Study
Specialized treatment of personality disorders (PD) in youth has been neglected for a long time, because these disorders were not diagnosed before the age of 18.
- Trial name
- NCT02518906
- Testing
- Adolescent Identity Treatment, DBT-A
- Where
- 3 sites in Chile, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- Klaus Schmeck
Psychophysiological Reactivity and Recovery
Physiology of Liberation
This academic study examines how everyday experiences are related to short-term physiological reactivity and recovery and whether one or more brief standardized mindfulness/attention-instruction sessions change these patterns.
- Trial name
- NCT07780266
- Testing
- Brief Standardized Mindfulness/Attention Instruction
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Healthy Young Adults
Investigating the Inverted-U Relationship Between Cognitive Performance and Plasma Epinephrine
Abstract Although acute resistance exercise has been suggested to enhance inhibitory control, a critical component of executive function, the mechanism by which acute exercise influences inhibitory control is unclear and there…
- Trial name
- NCT05407259
- Testing
- Resistance exercise
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Posttraumatic Stress Disorder
A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
The consolidation of learning is enhanced by adrenalin and other stress hormones. This memory enhancing effect is opposed by propranolol.
- Trial name
- NCT00709735
- Testing
- Propranolol
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital