Clinical trials: Psychoses, Substance Induced
Psychosis, Schizophrenia and Related Disorders
Community Reinforcement Approach and Family Training for Substance Use in Early Psychosis Intervention
The goal of this pilot feasibility and proof of concept study is to evaluate whether Community Reinforcement and Family Training (CRAFT) as adapted for group delivery in an early psychosis intervention (EPI) program has a…
- Conditions
- Psychosis, Schizophrenia and Related Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, Substance Use
- Trial name
- CRAFT-EPI (NCT05300633)
- Testing
- Group-Based Community Reinforcement Approach and Family Training-Early Psychosis Intervention (CRAFT-EPI)
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depression, Alzheimer's Disease
Retinoic Acid Homeostasis in Neuropsychiatric Diseases
It is hypothesized, that local retinoic acid (RA) homeostasis is functionally involved in the pathophysiology of depression. In a cross-sectional (and partly longitudinal) analysis, serum RA status will be assessed in healthy…
- Conditions
- Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia
- Trial name
- RAHND (NCT02439099)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alcohol Drinking, Alcohol-Related Disorders
Neuroimmune Dysfunction in Alcohol Use Disorder
The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation
- Trial name
- NCT04210713
- Testing
- Minocycline, Sugar pill
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Depression - Major Depressive Disorder, Bipolar
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health (BLOOM) is a project that aims to overcome age and diagnostic boundaries to generate person-specific longitudinal profiles of mental…
- Conditions
- Depression - Major Depressive Disorder, Bipolar, Psychosis, Eating Disorder NOS
- Trial name
- BLOOM (NCT06978452)
- Where
- Canada
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Alcohol Use Disorder (AUD), Schizophrenia and Related Disorders
Dynamics of Risk Perception and Risk Behavior in Alcohol Use Disorder and Schizophrenia
The hyper- or hypo-attribution of risks is deeply related to the core pathological mechanisms of mental disorders and at the same time engaging in risky behaviors influences their course and outcomes.
- Trial name
- PathRisk (NCT04985786)
- Testing
- Cognitive Behavioral Therapy for reducing risk behaviors, Cognitive Behavioral Therapy for increasing non-risk behaviors
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Tobacco Use Cessation, Tobacco Use Disorder
Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1
Schizophrenic individuals are typically nicotine dependent smokers who find it difficult to quit smoking. The purpose of this study is to determine the effectiveness of bupropion SR (commonly known as Zyban) in combination with a…
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Schizophrenia
- Trial name
- NCT00124683
- Testing
- Bupropion, nicotine transdermal patch
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Schizophrenia, Dual Diagnosis
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?
In this translational research proposal, based on our formulation, we seek to confirm and expand upon data obtained in our pilot study suggesting that cannabis and the cannabinoid agonist dronabinol, given in low dose to patients…
- Conditions
- Schizophrenia, Dual Diagnosis, Psychotic Disorder, Cannabis Use Disorder
- Trial name
- NCT01964404
- Testing
- Marijuana, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Post Traumatic Stress Disorder, Alcohol Use Disorder
FAAH Availability in Psychiatric Disorders: A PET Study
The aim of the present study is to examine Fatty Acid Amide Hydrolase (FAAH) availability in humans, including healthy individuals and across a spectrum of psychiatric disorders in which alterations in the endocannabinoid system…
- Conditions
- Post Traumatic Stress Disorder, Alcohol Use Disorder, Psychosis
- Trial name
- NCT04404712
- Testing
- [11C]MK-3168
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia, Nicotine Dependence
Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia
The goal of this clinical trial is to compare two active types of transcranial magnetic stimulation in two nicotine-using populations: nicotine-using people with psychosis and nicotine-using people without a diagnosis of a…
- Trial name
- NCT06389266
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Mental Health
Patient Generated Goals in Mental Health: Better Outcomes?
Researchers believe that clinical care can be improved by engaging patients and families directly in planning the care process. Engagement efforts have included asking patients/families to provide information about whether they…
- Trial name
- NCT03527914
- Testing
- Goal Based Outcomes, Treatment as Usual
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Traumatic Brain Injury, Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive…
- Conditions
- Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT04296604
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Alcohol Abuse
Bone Density in Patients With Schizophrenia
People with chronic mental disorder such as schizophrenia and alcohol abuse are high risk groups for developing osteoporosis. To evaluate the prevalence of bone mineral density in men patients with schizophrenia with alcohol…
- Trial name
- NCT00540267
- Testing
- No Intervention
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Inje University
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol Abuse, Mental Disorder
Drinks:Ration - Combat Stress Randomized Controlled Trial
Alcohol misuse is higher in the United Kingdom (UK) Armed Forces (AF) than the general population. Previous research has shown that interventions delivered via smartphone are efficacious in promoting self-monitoring of alcohol…
- Conditions
- Alcohol Abuse, Mental Disorder, Mental Health Issue
- Trial name
- Drinks:Ration (NCT04494594)
- Testing
- Drinks:Ration app
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- King's College London
Tobacco Dependence, Schizophrenia
The Appeal and Impact of E-cigarettes in Smokers With SMI
This study will evaluate behavioral and psychological appeal, toxicity, and effect of e-cigarettes on smoking behavior and nicotine addiction in chronic smokers with serious mental illness (SMI) who have failed to quit smoking.
- Conditions
- Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03050853
- Testing
- E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis, Ketamine
THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis
The aim of the research protocol is to evaluate cannabinoid-glutamate interactions in humans. As part of this aim the investigators will assess the safety and tolerability of the combination of NMDA antagonist, ketamine, and the…
- Trial name
- NCT04199468
- Testing
- Active Delta-9-THC, Active Ketamine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yale University
Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Expanded Game Squad for Neurodiverse Youth
The proposed study will pilot the use of an adapted Game Squad intervention aimed at improving physical activity and other important health behaviors (nutrition, sleep hygiene, screen time habits) for children and adolescents…
- Conditions
- Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Health Behavior, Developmental Disorder
- Trial name
- NDGameSquad (NCT03665415)
- Testing
- NDGameSquad
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merrimack College
Cannabis, Psychotic Disorders
Cannabinoids, Neural Synchrony, and Information Processing
The study examines the effects of delta-9-tetrahydrocannabinol (Δ9-THC), the principal active ingredient of cannabis, on neural synchrony. Neural synchrony is studied using electroencephalography (EEG).
- Trial name
- THC-Gamma (NCT00708994)
- Testing
- THC
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Yale University
None Volunteer
An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
The study team is studying how delta-9-tetrahydrocannabinol (THC) - the component of cannabis that is responsible for "getting people feeling high" - influences how people think about the behaviour of others and a variety of…
- Trial name
- NCT07878130
- Testing
- Low-dose THC administration via IV, High-Dose THC administration via IV, Saline administration via IV
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Substance-Related Disorders, Mental Disorder
Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up…
- Conditions
- Substance-Related Disorders, Mental Disorder, Social Stigma, Depression
- Trial name
- Siyakhana (NCT05282173)
- Testing
- Siyakhana CHW Training
- Where
- South Africa
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park