Clinical trials: Psychosis Prodrome
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Brain Imaging in Early Psychosis
This study assesses brain connectivity and function of individuals ages 13-25 at a prodromal or early stage of a psychotic disorder.
- Trial name
- NCT03932188
- Testing
- Mental Health Assessments and Computerized Cognitive Test, MRI scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Psychosis Nos/Other
Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis
The purpose of this study is to assess if patients who continue with antipsychotic treatment for 12 or more months show the same risk of relapse (measured by PANSS) that patients with the same medical condition who have followed…
- Trial name
- NONSTOP (NCT01765829)
- Testing
- Discontinuation antipsychotic treatment, Antipsychotic treatment
- Where
- 17 sites in Spain
- Volunteers
- 104 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Psychosis
Computer-Aided Learning for Managing Stress
The purpose of this study is to learn whether a new family therapy using computer games with biofeedback might help people at clinical high risk for psychosis and their family members learn to experience less stress and have…
- Trial name
- CALMS (NCT02531243)
- Testing
- CALMS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Beth Israel Deaconess Medical Center
Schizophrenias, Psychoses
Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia
The purpose of this study is to determine whether preventative treatment with sarcosine can reduce symptoms and delay/avoid disease progression in individuals defined as being in a prodromal stage of schizophrenia.
- Conditions
- Schizophrenias, Psychoses, Psychotic Disorders, Schizophrenic Disorders
- Trial name
- NCT00276263
- Testing
- Sarcosine (N-methylglycine)
- Where
- 2 sites in Israel
- Sponsor
- Herzog Hospital
Psychosis
Adaptation of Cognitive Enhancement Therapy for Persons at Clinical High Risk for Psychosis
The purpose of this study is to test the feasibility of a modification of CET (Cognitive Enhancement Therapy) to address symptomatic and functional difficulties associated with Clinical High Risk for Psychosis (CHR).
- Trial name
- CLUES (NCT02459210)
- Testing
- CLUES, therapy and computer games
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Beth Israel Deaconess Medical Center
Schizophrenia, Prodrome
Indicated Prevention With Omega-3 Fatty Acids in Adolescents With 'At-Risk-Mental-State' for Psychosis
Early intervention in psychosis might be associated with better outcomes. However, intervention in the pre-psychotic phase has been questioned as, using current criteria, only 20-50% of individuals classified as prodromal develop…
- Trial name
- NCT00396643
- Testing
- Omega 3 fatty acids
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Medical University of Vienna
Schizophrenia, Psychoses
Prodrome-Based Early Intervention With Antipsychotics vs. Benzodiazepines in First-Episode Schizophrenia
Prodrome based early intervention with an antipsychotic drug vs. benzodiazepine was applied in patients with first episode schizophrenia after one year neuroleptic maintenance treatment.
- Trial name
- NCT00159133
- Testing
- antipsychotics vs. Lorazepam (Drugs)
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Schizophrenia
Effectiveness of Neuroadaptive Cognitive Training in Adolescents at Risk for Psychosis
This study will evaluate the effectiveness of intensive computerized cognitive training in preventing the onset of psychotic disorder and improving adaptive functioning in adolescents at high risk of schizophrenia.
- Trial name
- NCT00655239
- Testing
- Neuroadaptive cognitive training, Computer games
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Schizophrenia, Psychosis
Psychological Intervention for Persons in the Early Initial Prodromal State
The purpose of this randomized controlled trial is to develop a cognitive behavioral therapy (CBT) for persons with at risk mental states in the early initial prodromal state and to evaluate CBT in comparison to supportive…
- Trial name
- NCT00204087
- Testing
- Cognitive behavioral therapy (CBT), Supportive Counselling (SC)
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- University of Cologne
22q11.2 Deletion Syndrome
Understanding of Psychotic Disorders in Children With 22q11.2DS
The study PremiCeS22 will investigate the prodromal signals at the onset of psychotic disorders of children with 22q11.2 deletion syndrome
- Trial name
- PremiCeS22 (NCT04639388)
- Testing
- neuropsychological testing, questionnaires and experimental tasks
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Psychotic Disorders
Dutch Prediction of Psychosis Study
The Dutch Prediction of Psychosis Study (DUPS) is a prospective study of predictors of the transition to psychosis in help-seeking adolescents at high risk for developing a first psychotic episode.
- Trial name
- NCT00188981
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Schizophrenia, Psychoses
Maintenance Treatment vs. Stepwise Drug Discontinuation in First-Episode Schizophrenia
After one year neuroleptic maintenance treatment in patients with first episode schizophrenia, neuroleptic treatment will be continued vs. stepwise discontinued (randomized design) over a period of 1 year.
- Trial name
- NCT00159120
- Testing
- maintained antipsychotic treatment vs. stepwise drug discontinuation
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Schizophrenia Prodrome
D-serine for the Schizophrenia Prodrome
The purpose of the study is to determine the safety and efficacy of D-serine as an early intervention treatment for the schizophrenia prodrome condition.
- Trial name
- NCT00826202
- Testing
- D-serine
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Prodromal Schizophrenia
Effects of NAC on Symptoms of CHR Patients
Schizophrenia is a chronic debilitating psychotic disorder. Identifying persons with "clinical high-risk" (CHR) symptoms, which are like those of schizophrenia but less severe, and providing psychiatric care to these individuals…
- Trial name
- NCT05142735
- Testing
- N-Acetylcysteine
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Centre for Addiction and Mental Health
Psychosis Prodrome
Ziprasidone in the Psychosis Prodrome
This study aims to determine whether ziprasidone is superior to placebo over 24 weeks for patients with the psychosis prodrome.
- Trial name
- ZIP (NCT00635700)
- Testing
- ziprasidone
- Where
- 11 sites in United States, Canada
- Volunteers
- 51 people
- Sponsor
- Yale University
Clinical High Risk Syndrome for Psychosis
PRIME vs Usual Care for Clinical High Risk
The purpose of this study is to determine whether specialty care is superior to usual care in the treatment of patients at clinical high risk for psychosis.
- Trial name
- NCT02960451
- Testing
- PRIME care, Usual care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Prodromal Schizophrenia
Effects of Cognitive Remediation on Cognition in Young People at Clinical High Risk of Psychosis
Onset of psychotic disorders such as schizophrenia, typically occurs during late adolescence or early adulthood often resulting in chronic social and occupational disability.
- Trial name
- NCT01619319
- Testing
- Cognitive Remediation Therapy, computer games
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Schizophrenia, Bipolar Disorder
Indicated Prevention of Psychotic Disorders With Low-dose Lithium
This study investigates the neuroprotective properties of low-dose lithium in young individuals at ultra-high risk of developping a first psychotic episode.
- Conditions
- Schizophrenia, Bipolar Disorder, Psychotic Disorders
- Trial name
- NCT00202306
- Testing
- lithium carbonate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Patients at Ultra-high Risk of Psychosis
Effects of Neurocognitive and Social Cognitive Remediation in Patients at Ultra-High Risk of Psychosis
Cognitive deficits are known to be a core feature of schizophrenia and seem to become manifest in the prodromal or Ultra-High Risk (UHR) state of psychosis.
- Trial name
- FOCUS (NCT02098408)
- Testing
- Cognitive remediation, Standard treatment
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Clinical High Risk for Psychosis
Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis
This project is a randomized-controlled trial to test the efficacy of computer-based targeted cognitive training (TCT) versus a placebo intervention of commercial computer games in adolescent/young adults at clinical high risk…
- Trial name
- NCT02404194
- Testing
- Targeted Cognitive Training, Computer Games
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Rush University Medical Center