Clinical trials: Psychosocial Stressors
Stress Disorders, Post-Traumatic, Depressive Disorder
Whole Health in VA Mental Health: Omnis Salutis
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use disorders.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Disorder, Anxiety Disorders, Substance-Related Disorders
- Trial name
- OS RCT (NCT05400252)
- Testing
- Omnis Salutis, Health and Wellness
- Where
- 2 sites in United States
- Volunteers
- 238 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder, Moral Injury
Psychosocial Rehabilitation After Moral Injury and Loss With Adaptive Disclosure
The aim of this study was to determine the efficacy of Adaptive Disclosure for Moral Injury and Loss (AD-MIL), a combat-specific psychotherapy for war-related PTSD stemming from Moral Injury (MI) and traumatic loss (TL) with Iraq…
- Conditions
- Post-traumatic Stress Disorder, Moral Injury, Traumatic Loss
- Trial name
- NCT03056157
- Testing
- Adaptive Disclosure for Moral Injury and Loss, Present Centered Therapy
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorder, Posttraumatic Stress Disorder
Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use
Individual with anxiety and post-traumatic stress disorder often use alcohol in ways that could cause them harm. Treating both mental health concerns and alcohol use at the same time can help reduce difficulties engaging in…
- Conditions
- Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
- Trial name
- NCT04871100
- Testing
- Unified Protocol- Alcohol, Usual care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Depression, Posttraumatic Stress Disorder
Effectiveness of Group Focused Psychosocial Support for Adults Affected by Humanitarian Crises
This is an effectiveness study of group problem management plus, a low-intensity psychological intervention, delivered in five sessions to adults affected by humanitarian crises.
- Conditions
- Depression, Posttraumatic Stress Disorder, Psychological Distress
- Trial name
- GroupPM+ (NCT03747055)
- Testing
- Group problem management plus, Enhanced treatment as usual
- Where
- Nepal
- Volunteers
- 611 people
- Sponsor
- George Washington University
Physical Activity, Psychosocial Stressors
Improving Physical and Psychosocial Well-being of African American Older Adults
The proposed research effort will: The purpose of this study is as follows: 1. Test the feasibility and acceptability of an eight-week community-based exercise program among AA older adults living in rural areas. 2.
- Trial name
- NCT03716037
- Testing
- Physical Activity for Life (PAL)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Quality of Life, Stigma, Social
App-based Psychosocial Intervention to Enhance Quality of Life in Arabic-speaking Refugees Residing in Switzerland
The ongoing warfare and economic instability in the Middle East and in North Africa causes many people to leave their home countries.
- Conditions
- Quality of Life, Stigma, Social, Depression, PTSD
- Trial name
- Sui (NCT05651737)
- Testing
- Sui App (SRK)
- Where
- Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Bern
Severe Eosinophilic Asthma, Psychological Distress
Severe Asthma, MepolizumaB and Affect: SAMBA Study
This is a real-life pragmatic non-randomised study to explore the impact of mepolizumab on the emotional and affective outcomes of patients with severe eosinophilic asthma and their partners.
- Conditions
- Severe Eosinophilic Asthma, Psychological Distress, Anxiety, Depression
- Trial name
- SAMBA (NCT04680611)
- Testing
- no study intervention. Patients receive standard clinical care
- Where
- 6 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Adverse Childhood Experiences, Vascular Dilatation
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity (adverse childhood experiences (ACEs)) with vascular endothelial (dys)function.
- Conditions
- Adverse Childhood Experiences, Vascular Dilatation, Sleep, Sleep Disturbance
- Trial name
- NCT06454344
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-i)
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Adolescent Behavior, Psychosocial Functioning
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
This study will deploy a scalable secondary prevention program that leverages existing foster youth transition services to improve mental health functioning and service use before and after exiting foster care.
- Conditions
- Adolescent Behavior, Psychosocial Functioning, Coping Behavior, Help-Seeking Behavior
- Trial name
- NCT06019377
- Testing
- Stronger Youth Networks and Coping (SYNC)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Portland State University
Posttraumatic Stress Disorder (PTSD)
fMRI Predictors of Treatment Response in Posttraumatic Stress Disorder (PTSD)
To employ a fear learning-extinction paradigm with functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) assessments among patients with posttraumatic stress disorder (PTSD) and trauma exposed healthy…
- Trial name
- NCT01576510
- Testing
- Prolonged Exposure (PE)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Psychosocial Functioning, Stress Disorders, Post-Traumatic
A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms
Posttraumatic stress disorder (PTSD) and depression are the two most common mental health conditions among Veterans. When Veterans experience both, there is a negative impact on their functioning, making it difficult to function…
- Conditions
- Psychosocial Functioning, Stress Disorders, Post-Traumatic, Depressive Disorder, Major
- Trial name
- NCT06689787
- Testing
- Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients
The purpose of this study is to explore the effect of an inflammatory and a psychosocial stressor and the combination thereof on mood in healthy young and elderly participants and patients with Major Depressive Disorder (MDD).
- Trial name
- NCT01533285
- Testing
- Salmonella typhi vaccine (Typhim Vi)
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Post Traumatic Stress Disorder, Cognitive Deficit
Investigating the Use of Goal Management Therapy in Improving Cognitive Functioning in Public Safety Personnel With PTSD
This study examines the efficacy of Goal Management Therapy (GMT) - a well-established cognitive remediation strategy aimed at improving goal-directed behaviors that are dependent on basic cognitive processes and on executive…
- Trial name
- NCT04251624
- Testing
- Goal Management Therapy, Psychosocial Education
- Where
- Canada
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Homewood Research Institute
Lung Cancer, Diagnoses Disease
Breaking Potentially Bad News in Lung Cancer Workup: Telephone Versus In-person Breaking of Final Diagnosis
Disclosure of bad news is challenging for patients, relatives and healthcare providers. Current protocols for breaking bad news assume a single, in-person meeting for breaking bad news, however cancer workup is not a single event…
- Conditions
- Lung Cancer, Diagnoses Disease, Psychosocial Stressor
- Trial name
- NCT04315207
- Testing
- Telephone call, In-person meeting
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Naestved Hospital
Stress Disorders, Post-Traumatic, Depression
Psychological and Psychosocial Intervention With War-Affected Children
The investigators are interested in knowing whether a group-based, trauma-focused intervention (Trauma Focused Cognitive Behavioral Therapy) is superior to a more general, non trauma-focused, psychosocial intervention (Child…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety, Conduct
- Trial name
- NCT01509872
- Testing
- Trauma Focused Cognitive Behavioral Therapy, Child Friendly Space
- Where
- Republic of the Congo
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
HIV
Men of African American Legacy Empowering Self
The MAALES Project is a community collaborative intervention designed to prevent HIV infection and transmission among African American men who have sex with both men and women.
- Trial name
- MAALES (NCT01492530)
- Testing
- Men of African American Legacy Empowering Self, Standard HIV Education & Risk Reduction
- Where
- 2 sites in United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Psychological Distress, Psychological Trauma
Implementing Psychosocial Interventions to Syrian Refugee Women Who Are Exposed to Psychological Trauma
This study assesses severity of trauma, depression and anxiety symptoms of Syrian women under temporary protection who reside in Istanbul and types of exposed trauma that they have experienced.
- Trial name
- NCT03912077
- Testing
- Culturally Adapted Cognitive Behavioural Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Istanbul Sehir University
Violence, Sexual, Violence, Physical
Online Psychosocial Intervention for Nursing Students Who Experienced Intimate Partner Abuse in Turkey
Intimate partner abuse is very common among university students. Post-traumatic stress disorder is one of the most serious mental diseases caused by intimate partner abuse.The purpose of this study was to assess the impact of an…
- Conditions
- Violence, Sexual, Violence, Physical, Violence, Gender-Based, Violence
- Trial name
- NCT05368779
- Testing
- The internet-based psychosocial intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Bozok University
Intimate Partner Violence, Depression
Psychosocial Intervention With Community Worker Support for Survivors of Intimate Partner Violence
Female survivors of domestic violence (DV) may exhibit various mental health problems. A variety of psychotherapies are available to improve their mental health, however there is uncertainty on which is the best.
- Conditions
- Intimate Partner Violence, Depression, Anxiety, Post-traumatic Stress Disorder
- Trial name
- IPCCOS (NCT03333798)
- Testing
- Cognitive-Behavioral Intervention, Standard psychosocial care
- Volunteers
- 200 people
- Sponsor
- Universidad del Valle, Colombia
Mental Health, Psychological Trauma
Pathway-Matched Resilience-Oriented Therapy in Rwanda
This pragmatic, pathway-stratified, cluster-randomized waitlist-controlled trial evaluated Resilience-Oriented Therapy (RoT), a culturally adapted group-based psychosocial intervention for post-genocide Rwanda.
- Conditions
- Mental Health, Psychological Trauma, Stress Disorders, Post-Traumatic, Depression
- Trial name
- RoT-CRT (NCT07621731)
- Testing
- Resilience-Oriented Therapy - Emotion-Regulation Variant, Resilience-Oriented Therapy - Identity-Development Variant, Resilience-Oriented Therapy - Behavioural Self-Management Variant
- Where
- 5 sites in Rwanda
- Volunteers
- 427 people
- Sponsor
- Alexandros Lordos, PhD