Clinical trials: Psychotic Disorders
Schizophrenia
Magnetic Seizure Therapy for Schizophrenia
This trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (MST) and its safety among schizophrenia patients.
- Trial name
- NCT02746965
- Testing
- Magpro X100 + Option, ThymatronSystem Ⅳ Electroconvulsive System, treatment as usual (TAU)
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Shanghai Mental Health Center
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Schizophrenia, Psychotic Disorders
Recovery Therapy Trial
This project will systematically apply a specialist version of Cognitive Behaviour Therapy (CBT), known as Recovery Therapy, to a random sample of patients with psychotic disorders.
- Conditions
- Schizophrenia, Psychotic Disorders, Mood Disorders
- Trial name
- NCT00239122
- Testing
- Recovery Therapy (Cognitive Behaviour Therapy for psychosis)
- Where
- 2 sites in Australia
- Volunteers
- 94 people
- Sponsor
- Melbourne Health
Psychosis
Compassion Focused Therapy for Distressing Experiences
This study aims to develop and test the feasibility of a new therapy called Compassion Focused Therapy (CFT) for psychosis. This therapy helps people with psychosis manage distressing experiences by building internal feelings of…
- Trial name
- NCT02733575
- Testing
- Compassion Focused Therapy
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- King's College London
Common Mental Disorder
Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders
To explore the whole-brain anatomical and functional abnormalities in drug-naive patients with schizophrenia ,drug-naive patients with BD, drug-naive patients with MDD and healthy controls by using a combination of…
- Trial name
- NCT04218981
- Testing
- Antipsychotic drugs, Mood stabilizer, Paroxetine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Schizophrenia, Moral Status
Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia
Moral cognition is an important and multidimensional, but often overlooked, determinant of violence. Very few interventions have systematically examined the role of moral reasoning, anger management and problem-solving together…
- Conditions
- Schizophrenia, Moral Status, Violence
- Trial name
- NCT05207319
- Testing
- integrated Moral Reasoning Development Intervention (MRDI)
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- I-Shou University
Schizophrenia, Hallucinations
Evaluation of Internet-based Cognitive Behavioral Self-help Treatments for People With Psychosis
Schizophrenia is a severe mental disorder which is accompanied by an enormous individual and societal burden. Despite established efficacy of cognitive behavioral therapy for psychosis (CBTp), its dissemination into routine…
- Conditions
- Schizophrenia, Hallucinations, Persecutory Delusion
- Trial name
- EviBaS (NCT02974400)
- Testing
- Internet-based, CBT-oriented, guided self-help
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 101 people
- Sponsor
- University of Bern
Schizophrenia
A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia
A Clinical Study to learn if SEP-363856 has physical dependence in adults with schizophrenia. This study will be held in approximately 6 study sites in the United States.
- Trial name
- NCT05848700
- Testing
- SEP-363856
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Schizophrenia, Schizoaffective Disorder
A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder
Varenicline (Chantix) is a smoking cessation treatment that was approved in 2006 by the FDA for treatment of nicotine dependence and may be particularly beneficial in smokers with schizophrenia or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
- Trial name
- SCRP (NCT00621777)
- Testing
- Varenicline
- Where
- 10 sites in United States
- Volunteers
- 247 people
- Sponsor
- Massachusetts General Hospital
Bipolar I Disorder, Schizoaffective Disorder
Open Label Extension Study of NCT06221852
This is a 12-week open-label extension study for participants completing study NCT06221852.
- Conditions
- Bipolar I Disorder, Schizoaffective Disorder, Psychosis
- Trial name
- NCT06558201
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Schizophrenia
Long-Term Safety Extension Trial of Asenapine in Schizophrenia Participants Who Completed Protocol P05688 (P05689)
Participants who have completed the 6-week trial P05688 can be screened for eligibility for this 26-week extension study in which they will continue treatment.
- Trial name
- NCT01617200
- Testing
- Asenapine, Olanzapine
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Forest Laboratories
Schizophrenia
Effects of Narrative Enhancement and Cognitive Therapy (NECT) on Self-stigma in Patients With Schizophrenia
This study aims to explore the effect of narrative enhancement and cognitive therapy in improving self-stigma, self-esteem, depression and hope of patients with chronic schizophrenia.
- Trial name
- NCT03967431
- Testing
- Narrative Enhancement and Cognitive Therapy (NECT)
- Where
- Taiwan
- Volunteers
- 86 people
- Sponsor
- National Yang Ming Chiao Tung University
Major Depressive Disorder, Bipolar Disorder
Taking Action for College Students
The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT06700902
- Testing
- Taking Action
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Temple University
Schizophrenia, Schizophrenic Disorders
Open-label Study of Flexible-dose Paliperidone ER (Extended Release) to Treat Adolescent Schizophrenia.
The purpose of this open-label study is to evaluate the long-term (6-month) safety and tolerability of extended-release paliperidone, an atypical antipsychotic, given in flexible dosages to adolescents with schizophrenia.
- Conditions
- Schizophrenia, Schizophrenic Disorders, Psychotic Disorders, Dementia Praecox
- Trial name
- NCT00488319
- Testing
- Paliperidone ER
- Where
- 53 sites in United States, Belgium and 9 more
- Volunteers
- 400 people
- Sponsor
- Janssen Research & Development, LLC
Mental Health Issue, Transdiagnostic Mechanisms
Efficacy of a Transdiagnostic Online Prevention Approach in Adolescents (EMPATIA)
The goal of this randomized controlled clinical trial is to investigate the efficacy of the internet-delivered intervention EMPATIA on general psychopathology of adolescents with subclinical symptoms compared to a Care As Usual…
- Conditions
- Mental Health Issue, Transdiagnostic Mechanisms, Adolescent Psychology, Prevention
- Trial name
- EMPATIA (NCT05934019)
- Testing
- EMPATIA 1
- Where
- Switzerland
- Volunteers
- 158 people
- Sponsor
- University of Bern
Schizophrenia, Schizoaffective Disorder
Treatment of Negative Symptoms of Schizophrenia With Transcranial Magnetic Stimulation (TMS)
This study will test whether repetitive transcranial magnetic stimulation (rTMS) is helpful in treating negative symptoms and social deficits of schizophrenia.
- Trial name
- NCT00517075
- Testing
- Transcranial Magnetic Stimulation (TMS), repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
Severe Mental Illness, Nicotine Dependence
Electronic Decision Support Systems for Smokers With Severe Mental Illness
This randomized clinical trial among SMI smokers assessed whether the EDSS with carbon monoxide monitor and health-checklist feedback lead to higher rates of initiation of smoking cessation treatment, days of smoking abstinence…
- Conditions
- Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
- Trial name
- NCT01412866
- Testing
- EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Cognitive Dysfunction
Supportive Psychotherapy as Adjunct to Risperidone for Cognitive Function and Inflammation in Schizophrenia
This study examined whether adding structured supportive psychotherapy to risperidone treatment is more effective than risperidone alone in improving cognitive function and reducing inflammation in patients with schizophrenia.
- Conditions
- Schizophrenia, Cognitive Dysfunction, Inflamation
- Trial name
- SUPPORT-SCZ (NCT07477301)
- Testing
- Structured Supportive Psychotherapy, Risperidone 2 mg
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- Hasanuddin University
Schizophrenia
Parallel Effects of Schizophrenia and N-methyl-D-aspartate (NMDA) Antagonism
This study investigates the common features of electrophysiological measures in schizophrenia and effects of NMDA antagonist ketamine in healthy volunteers.
- Trial name
- NCT02675530
- Testing
- ketamine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer Disease, Alzheimer Disease With Delusions
Tau Networks in Psychotic Alzheimer's Disease
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology.
- Conditions
- Alzheimer Disease, Alzheimer Disease With Delusions, Alzheimer Disease With Psychosis
- Trial name
- NCT05847192
- Testing
- [18F]-PI2620 PET scan
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwell Health