Clinical trials: Psychotic Disorders
Schizophrenia
18F-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography (PET) Study to Explore Dopamine Synthesis Capacity in the Whole Striatum After 2 Weeks of Treatment With Ralmitaront or Placebo in Participants With Schizophrenia
This study is an exploratory proof of mechanism (POM) study using PET/functional magnetic resonance imaging (fMRI) in a 2-period, 2-sequence, crossover design.
- Trial name
- NCT06880328
- Testing
- Ralmitaront, Radiolabeled PET tracer [18F]-DOPA
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Hoffmann-La Roche
Schizophrenia
CONNEX-3: A Study to Test Whether Iclepertin Improves Learning and Memory in People With Schizophrenia
This study is open to adults with schizophrenia. Schizophrenia can affect the way a person thinks, their memory and their mental functioning.
- Trial name
- NCT04860830
- Testing
- Iclepertin
- Where
- 110 sites in United States, Argentina and 16 more
- Volunteers
- 609 people
- Sponsor
- Boehringer Ingelheim
Cancer, Severe Major Depression
Adapting the Tumor Board Model for Mental Illness and Cancer
This study examines the feasibility and acceptability of a virtual tumor board for cancer and mental illness for patients with serious mental illness and a new cancer diagnosis.
- Conditions
- Cancer, Severe Major Depression, Schizophrenia, Bipolar Disorder
- Trial name
- NCT05837598
- Testing
- Virtual Cancer and Mental Health Tumor Board
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Mental Disorder
Testing the Effectiveness of an Evening Blue-depleted Light Environment in an Acute Psychiatric Ward
There is increasing recognition of the need to stabilize sleep-wake cycles in individuals with major mental disorders. As such, clinicians and researchers advocate for the use of interventions targeted at sleep and circadian…
- Trial name
- NCT03788993
- Testing
- Blue-depleted evening light condition, Normal light condition
- Where
- Norway
- Volunteers
- 475 people
- Sponsor
- St. Olavs Hospital
Schizophrenia, Schizoaffective Disorder
Study of the Effects of Glycine on Symptoms and Memory in Patients With Schizophrenia
The goal of this project is to understand whether glycine is helpful for improving some symptoms of schizophrenia such as low motivation, loss of interest, and social isolation.
- Trial name
- NCT00575848
- Testing
- Glycine
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- North Suffolk Mental Health Association
Schizophrenia Spectrum Disorder, Schizophrenia
RISE (Rehabilitation Intervention for People With Schizophrenia in Ethiopia)
The purpose of this study is to determine whether community-based rehabilitation plus facility-based care is superior to facility-based care alone in reducing disability related to schizophrenia in rural Ethiopia.
- Conditions
- Schizophrenia Spectrum Disorder, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- RISE (NCT02160249)
- Testing
- Community-based rehabilitation, Facility based care
- Where
- Ethiopia
- Volunteers
- 166 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Schizophrenia, Psychosis
The Music Study in Refractory Psychosis
The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in…
- Trial name
- MARS (NCT02431949)
- Testing
- Admission to BCPP
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Agitation Associated With, Alzheimer's Disease
Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
To compare the efficacy of flexible dosing of brexpiprazole with placebo in subjects with agitation associated with dementia of the Alzheimer's type
- Conditions
- Agitation Associated With, Alzheimer's Disease, Alzheimer's Type, Mental Disorder
- Trial name
- NCT01922258
- Testing
- Brexpiprazole, OPC-34712
- Where
- 70 sites in United States, Bulgaria and 7 more
- Volunteers
- 270 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Psychosis, Mental Disorder
Assessment and Evolution of Narrative Identity and Its Relationship to Subjective Multidimensional Well-being and Multidimensional Recovery in First Episode Psychosis
First episode psychosis (FEP) constitutes an important subgroup within psychotic disorders, as the acute impact of a disorder at the time of diagnosis may differ from its long-term impact over the following decades.
- Trial name
- PEPID (NCT07330843)
- Testing
- Narrative identity task
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Clozapine Resistant Schizophrenia
Vitamin D for Schizophrenia
Background: Despite improvements in medications, treatment delivery and rehabilitation, schizophrenia outcomes remain suboptimal. There are a proportion of 30-40% treatment-resistant schizophrenia patients.
- Trial name
- NCT01759485
- Testing
- Vitamin D3
- Where
- Israel
- Volunteers
- 47 people
- Sponsor
- Geha Mental Health Center
Psychotic Disorder
Treating Early Stages With an Intervention Targeting Cognitive Reserve
This study proposes continuity in the implementation of a psychological approach program to enhance cognitive reserve (CR) in children, adolescent and young adults, off-springs of patients with schizophrenia or bipolar disorder…
- Trial name
- TESORO (NCT05288049)
- Testing
- Enhancing cognitive reserve, Support therapy
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Cognitive Dysfunction, Schizophrenia
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 to 55 Years
This first-in-human clinical trial with a randomized, double-blind, placebo-controlled, dose-escalation study design is regarded as standard to test the safety, tolerability, and pharmacokinetics of KYN-5356.
- Trial name
- NCT06225115
- Testing
- KYN-5356
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kynexis B.V.
Schizophrenia
An Open-Label Study of Aripiprazole Lauroxil in Subjects With Stable Schizophrenia
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of various doses and dosing intervals of aripiprazole lauroxil.
- Trial name
- NCT02320032
- Testing
- Aripiprazole Lauroxil
- Where
- 16 sites in United States
- Volunteers
- 140 people
- Sponsor
- Alkermes, Inc.
Schizophrenia
Treatment of Social Cognition in Schizophrenia Trial
This study is a multi-site, prospective, parallel arm, double-blind, randomized, controlled clinical trial to assess the efficacy of an experimental software program targeting social cognitive abilities versus a computer-based…
- Trial name
- TRuSST (NCT02246426)
- Testing
- Computerized plasticity-based adaptive cognitive training, Commercially available computerized training
- Where
- 4 sites in United States
- Volunteers
- 149 people
- Sponsor
- Posit Science Corporation
Schizophrenia
Effects of Oxytocin on Negative Symptoms and Social Cognition in Schizophrenia and Its Possible Mechanisms
The purpose of this study was to investigate the effects of oxytocin on negative symptoms and social cognitive task performance in schizophrenia.
- Trial name
- NCT03662425
- Testing
- Oxytocin, Saline
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Shanghai Mental Health Center
Neuroinflammatory Response, Psychosis
Neuroinflammation Markers in Subjects With Psychotic Symptoms
The main objective of the study is to measure the plasma and intracellular levels of several neuroinflammation markers (including cytokines and chemokines) and the endocannabinoid system in subjects presenting psychotic symptoms…
- Trial name
- NEUROINPS17 (NCT05815225)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Mental Illness, Schizophrenia
The Use of Skills Training to Augment Compensated Work Therapy (CWT)/VI for Veterans With SMI
The goal of this study is to evaluate the efficacy of a combined social skills training and cognitive-behavioral therapy intervention for seriously mentally ill Veterans as they begin employment.
- Trial name
- MPROVE (NCT00272168)
- Testing
- Maryland Program for Vocational Effectiveness, Supportive Treatment for SMI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- VA Office of Research and Development
Schizophrenia
rTMS for Auditory Hallucinations Guided by Magnetoencephalography
rTMS and MEG for auditory hallucinations via self controlled clinical trials. Repetitive transcranial magnetic stimulation (rTMS) can increase or decrease cortical excitability in patients with psychosis (such as schizophrenia).
- Trial name
- NCT05598450
- Testing
- rTMS and MEG for auditory hallucinations via self controlled clinical trials
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Psychotic Disorders
Relative Bioavailability of LY03010 Compared to Listed Drug
This is a randomized, multiple-dose, open-label, parallel-group study. Subjects will undergo screening evaluations to determine eligibility within 28 days prior to study drug administration.
- Conditions
- Schizophrenia, Psychotic Disorders, Mood Disorders, Schizophrenia Spectrum
- Trial name
- NCT04922593
- Testing
- LY03010; paliperidone palmitate, INVEGA SUSTENNA
- Where
- 9 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Schizophrenia, Schizoaffective Disorder
Integrated Psychoeducation Program for Internalized Stigma in Schizophrenia
The goal of this pilot randomized controlled trial is to investigate whether the Integrated Psychoeducation Program reduces internalized stigma and improves related outcomes in adults with schizophrenia or schizoaffective…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Internalized Stigma, Social Stigma
- Trial name
- NCT07898852
- Testing
- Integrated Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Dokuz Eylul University