Clinical trials: Psychotic Mood Disorders
Schizophrenia, Bipolar Disorder
Longitudinal Effect of Electroconvulsive Therapy on Schizophrenia and Bipolar Disorder: a MRI Study
For more severe and treatment-resistant cases in schizophrenia and bipolar disorder, electroconvulsive therapy (ECT) is often very effective.
- Trial name
- NCT03651674
- Testing
- ECT treatment, Drug treatment
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xidian University
Bipolar Disorder, Major Depressive Disorder
A Study of Pregnant and Postpartum Women With and Without Mood Disorders
This study is looking at genetic, biological, and environmental causes and how all three may work together to cause postpartum mood episodes.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Postpartum Depression, Postpartum Psychosis
- Trial name
- NCT03615794
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Dementia With Lewy Bodies (DLB)
Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder
This is a retrospective observational study to evaluate the clinical utility of blood-based biomarkers in the diagnosis and management of patients with a neurodegenerative disease (ND) or mental disorder (MD).
- Conditions
- Alzheimer Disease, Dementia With Lewy Bodies (DLB), Frontotemporal Dementia (FTD), Major Depressive Disorder (MDD)
- Trial name
- Synapsing-BK (NCT07314190)
- Where
- Spain
- Volunteers
- 1,799 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Schizophrenia, Bipolar Disorder
Time and Virtual Reality in Schizophrenia and Bipolar Disorder
Patients with bipolar disorders report an acceleration or slowing of time flow, and patients with schizophrenic spectrum disorders a time fragmentation. These disorders would be linked to disorders of the sense of self.
- Trial name
- VirtualTimes (NCT04432116)
- Testing
- virtual reality 1, virtual reality 2
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease, Schizophrenia
Multi-center Imaging Genetics Studies in China
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
- Conditions
- Alzheimer Disease, Schizophrenia, Major Depressive Disorders
- Trial name
- CHIMGEN (NCT02681822)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Psychotic Disorders, Depressive Disorder
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression
We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression.
- Conditions
- Psychotic Disorders, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00691535
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia
A Study of the Effect of Food and Posture on the Pharmacokinetics of a Single Dose of ER OROS Paliperidone
The purposes of this study are to evaluate the effect of food on the pharmacokinetics of extended-release (ER) OROS paliperidone in healthy men, and to evaluate the effect of posture on the pharmacokinetics of ER OROS…
- Trial name
- NCT00838669
- Testing
- Extended release OROS paliperidone
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bipolar Disorder, Schizophrenia
Change in Brain Bioenergetics in Bipolar Disorder in Response to Photic Stimulation
This study aims to gather additional information to support the theory that bipolar disorder is due to cellular (mitochondrial) dysfunction.
- Conditions
- Bipolar Disorder, Schizophrenia, Healthy Controls
- Trial name
- NCT00801567
- Testing
- Magnetic resonance spectroscopy (MRS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Schizophrenia, Bipolar Disorder
Characterization of Emotional Processing of Information in Bipolar Disorder and Schizophrenic Patients
In the case of psychotic disorders such as bipolar disorder or schizophrenia, attention dysfunction contribute, according to the theories of neuroscience, the development of mood disorders following disturbances in the…
- Trial name
- EMOBISCHI (NCT02841345)
- Testing
- behavioral and fMRI
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Psychotic Disorders, Cognitive Impairment
Cognitive Impairments in Psychotic Disorders
Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first…
- Trial name
- NCT05597579
- Testing
- DAPAR Tests (IQ equivalent test)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Major Depressive Disorder, Psychotic Disorders
Safety Study of ORG 34517 for Major Depression With Psychotic Features
Patients suffering from Major Depressive Disorder with Psychotic features who have received no changes in their medications in the previous two weeks will receive "usual" treatment of antidepressants, antipsychotics and/or mood…
- Trial name
- NCT00226278
- Testing
- ORG 34517
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
First-Episode Psychosis, Bipolar Disorder
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI
Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.
- Trial name
- CARB (NCT02334904)
- Testing
- Aripiprazole, Risperidone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Schizophrenia, Bipolar Disorder
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications
Previous and our studies have shown that cognitive impairments are core symptoms of three major psychiatric disorders-schizophrenia, bipolar disorder, and major depressive disorder, and are associated with underlying brain…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder (MDD)
- Trial name
- NCT07444463
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central South University
Schizophrenia, Psychotic Disorders
Relative Bioavailability of LY03010 Compared to Listed Drug
This is a randomized, multiple-dose, open-label, parallel-group study. Subjects will undergo screening evaluations to determine eligibility within 28 days prior to study drug administration.
- Conditions
- Schizophrenia, Psychotic Disorders, Mood Disorders, Schizophrenia Spectrum
- Trial name
- NCT04922593
- Testing
- LY03010; paliperidone palmitate, INVEGA SUSTENNA
- Where
- 9 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Schizophrenia, Bipolar Disorder
Individualizing Incentives for Alcohol in the Severely Mentally Ill
The investigators will evaluate the efficacy of a 2 various contingency management (CM) interventions (High-Magnitude CM, Shaping CM) for treating heavy drinking among individuals with serious mental illness and alcohol…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Alcohol Dependence
- Trial name
- NCT03481049
- Testing
- Usual CM, High-Magnitude CM, Shaping CM
- Where
- 2 sites in United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Washington State University
Schizophrenia Disorders, Bipolar Disorder
Visual Perception in Schizophrenia
This study aims to identify novel markers of psychosis using electroencephalography (EEG).
- Conditions
- Schizophrenia Disorders, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- NCT06911931
- Testing
- EEG measure of visual processing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital