Clinical trials: Psychotic Symptoms
Schizophrenia
A Trial of Folate With B12 in Patients With Schizophrenia With Residual Symptoms in Ethiopia
The investigators propose to conduct a randomized Sequential Parallel Design for Double-Blind Phase fixed dose, 4-month trial of folate plus B12 as add-on therapy in 200 Ethiopian subjects with schizophrenia with stable residual…
- Trial name
- NCT01724476
- Testing
- folate with B12
- Where
- Ethiopia
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Schizoaffective Disorder
Artemisinin to Reduce The Symptoms of Schizophrenia
The investigators intend to explore the hypothesis that symptoms of schizophrenia may be reduced by the antimalarial compound artemisinin when used in addition to standard antipsychotic medications.
- Trial name
- NCT00753506
- Testing
- Artemisinin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Sheppard Pratt Health System
Schizophrenia, Constipation
Effects of Psyllium on Constipation in Schizo-phrenic: A Randomized Controlled Crossover Trial
Constipation in schizophrenia is an important issue in clinical care. Constipation needs psychiatric professionals concerning and providing intervention because it may cause ileus and lead to death.
- Trial name
- NCT05528146
- Testing
- Psyllium huks
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Hungkuang University
Negative Symptoms in Schizophrenia, Brain Stimulation Intervention
Combining HD-tDCS and iTBS in Treating Negative Symptoms of Schizophrenia
Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is central to the persistence of negative symptoms in schizophrenia. Both HD-tDCS and iTBS targeting the left DLPFC have shown therapeutic benefit.
- Trial name
- NCT07680959
- Testing
- active iTBS followed by active HD-tDCS
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Early Psychosis, Psychotic Disorders
Effects of an Acceptance-based Medication Adherence Therapy for Recent-onset Psychosis
This randomized controlled trial aimed to examine the effectiveness of a 10-session acceptance-based, insight-inducing medication adherence therapy (AIM-AT) program for recent-onset psychosis (in addition to usual care) over a…
- Trial name
- AIM_AT (NCT06192602)
- Testing
- AIM_AT, CPG, TAU
- Where
- Hong Kong
- Volunteers
- 126 people
- Sponsor
- Chinese University of Hong Kong
Obesity, Metabolic Syndrome
Effects of Adjunctive Metformin on Metabolic Profiles in Clozapine-treated Schizophrenic Patients
Background: Several studies have suggested that clozapine has the greatest propensity of all available atypical antipsychotics to induce weight gain and metabolic dysregulation.
- Conditions
- Obesity, Metabolic Syndrome, Schizophrenia
- Trial name
- NCT01300637
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University WanFang Hospital
Schizophrenia
The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia
The primary objectives of this application are to determine if the selective ERβ agonist LY500307, when added to antipsychotic medications, improves negative and/or cognitive symptoms in patients with schizophrenia.
- Trial name
- Beta (NCT01874756)
- Testing
- LY500307 150mg, LY500307 75mg, LY500307 25mg
- Where
- 4 sites in United States
- Volunteers
- 95 people
- Sponsor
- Indiana University
Schizophrenia
Magnetoencephalographic (MEG) Correlates of Negative Symptoms in Patients Suffering From Schizophrenia and Their Influence by Add-on Treatments
The objective of the suggested study is to identify changes in MEG correlates caused by the add-on treatment with the changes in negative symptoms of schizophrenia by comparing the change in the MEG correlates of the subjects…
- Trial name
- NCT00894296
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Brain Imaging in Early Psychosis
This study assesses brain connectivity and function of individuals ages 13-25 at a prodromal or early stage of a psychotic disorder.
- Trial name
- NCT03932188
- Testing
- Mental Health Assessments and Computerized Cognitive Test, MRI scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cognitive Therapy
Exploring the Effectiveness of Group Cognitive Stimulation Therapy in People With Schizophrenia.
Background: Cognitive dysfunction is the core defect of schizophrenia, which seriously affects the emotional, social functions and quality of life in people with schizophrenia.
- Trial name
- NCT04916483
- Testing
- group cognitive stimulation therapy, usual care
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Yang Ming Chiao Tung University
Adolescent Schizophrenia, Child or Adolescent Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features
Safety and Tolerability of Aripiprazole in Adolescents With Schizophrenia or Children and Adolescents With Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features.
This is an open-label study consisting of a screening period, a conversion/titration phase (Phase 1), an open-label treatment phase (Phase 2), and a follow-up period.
- Trial name
- ATTAIN 267 (NCT01122927)
- Testing
- Aripiprazole
- Where
- 101 sites in United States, Bulgaria and 11 more
- Volunteers
- 524 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Akathisia, Drug-Induced, Dyskinesia, Drug-Induced
Study of Preladenant for the Treatment of Antipsychotic Induced Movement Disorders in Participants With Schizophrenia (Study P04628)
This study was designed to determine if preladenant (SCH 420814, MK-3814) can reduce drug-induced involuntary movements in participants with schizophrenia or schizoaffective disorder.
- Conditions
- Akathisia, Drug-Induced, Dyskinesia, Drug-Induced, Parkinsonian Disorders
- Trial name
- NCT00686699
- Testing
- Preladenant
- Volunteers
- 11 people
- Sponsor
- Merck Sharp & Dohme LLC
Schizophrenia
Virtual Rehabilitation for the Treatment of Motivational Deficits in Schizophrenia
The loss of motivation has emerged as a critical symptom in schizophrenia that is consistently linked to functional disability for affected individuals.
- Trial name
- NCT02709733
- Testing
- VR Motivation Training
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Obesity
Lifestyle Intervention for Weight Gain Management for Patients With Schizophrenia
The aims of this study were to evaluate the efficacy of an intervention for weight gain management for patients from schizophrenia spectrum compared to treatment as usual (TAU), and to evaluate the effects of this program on…
- Trial name
- NCT01368406
- Testing
- wellness program
- Where
- 4 sites in Brazil
- Volunteers
- 160 people
- Sponsor
- Federal University of São Paulo
Schizophrenia, Schizoaffective Disorder
Clinical Estradiol Trial in Women With Schizophrenia
To investigate the 'estrogen-protection' hypothesis by comparing changes in psychotic symptoms between one group of patients receiving standard antipsychotic drug treatment plus placebo and a second matched group receiving…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT00206570
- Testing
- Estradiol
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Bayside Health
Bipolar Disorder, Depression
Pediatric Bipolar Registry
The goal of the Pediatric Bipolar Registry (PBR) is to provide a comprehensive assessment regarding the diagnosis and treatment of pediatric bipolar disorder to children and adolescents with any current mood state and/or…
- Conditions
- Bipolar Disorder, Depression, Mania, Psychosis
- Trial name
- PBR (NCT02360267)
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- The University of Texas Health Science Center, Houston
Schizophrenia
Schizophrenia, Related Troubles and Glutathione: Clinical Trial. Effects of Oral Administration of N-Acetylcysteine (NAC) on the Brain Glutathione Level and on the Symptoms of Schizophrenia
The results of the study "schizophrenia, related disorders and glutathione" conducted at the Laboratory of Psychiatric Neuroscience (LUNEP) DUPA of Lausanne, reinforce the hypothesis proposed that a deficit intracerebral…
- Trial name
- NCT01506765
- Testing
- N-Acetyl-Cysteine (NAC)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Schizophrenia
A Comparison of Study Drug With Placebo and Haloperidol in Patients With Schizophrenia
The purpose of this study is to evaluate the efficacy of the drug SM-13496 compared to a placebo and to haloperidol in patients with schizophrenia.
- Trial name
- NCT00044044
- Testing
- Lurasidone 20 mg, Lurasidone 40mg, Lurasidone 80 mg
- Where
- 34 sites in United States
- Volunteers
- 356 people
- Sponsor
- Sumitomo Pharma America, Inc.
Schizophrenia, Bipolar Disorder
Dental Status of Patients With Severe Mental Illness
The investigators aim to assess the dental status of psychiatric patients suffering from severe mental illness (schizophrenia, bipolar disorder, ptsd, resistant depression).
- Conditions
- Schizophrenia, Bipolar Disorder, PTSD, Depression
- Trial name
- SMI-DENTAL (NCT01315509)
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Hadassah Medical Organization
Major Depressive Disorder, Depression
An Investigation of the Relationship Between Omega-3 Fatty Acid Nutrition and Mental Health in Children and Adolescents
This is an observational case-control add-on study to an investigator-initiated clinical trial (IICT) (ClinicalTrials.gov Identifier: NCT03167307): Omega-3 fatty acids as firstline treatment in pediatric depression.
- Conditions
- Major Depressive Disorder, Depression, Child Mental Disorder
- Trial name
- NCT04158869
- Where
- Switzerland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
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