Clinical trials: Psychotropic Drugs, active
Alcohol Consumption, Psychoactive Substance Use
AlcoTail - Implementation of Tailored Interventions
This study aims to investigate the implementation and real-world effects of an intervention for harmful use of alcohol and psychoactive medicinal drugs among hospital inpatients.
- Trial name
- NCT04957628
- Testing
- Harmful alcohol use treatment, Non-prescribed psychoactive medicinal use treatment
- Where
- Norway
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Falls (Accidents) in Old Age, Psychotropic Drugs
Association Between Intake of Psychotropic Medications and Risk of Falls in Older Adults
The aim of the study is to assess the association between intake of psychotropic medications and increased risk of falls in older adults discharged from Ain Shams University Geriatric Hospital as a primary outcome and incident…
- Trial name
- NCT07112573
- Where
- Egypt
- Volunteers
- 398 people
- Sponsor
- Ain Shams University
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Challenging Behavior, Autism Spectrum Disorder
Measurement of Treatment Effects
The overall objective is to evaluate and compare the efficacy of two common treatments for CB in children and adolescents with autism using multiple outcome measures.
- Trial name
- NCT07024303
- Testing
- Psychotropic medication (at discretion of psychiatrist), Behavioral therapy
- Volunteers
- 20 people
- Sponsor
- Matthew J O'Brien, PhD, BCBA-D
Abdominal Injuries, Alcohol Intoxication
Alcohol, Psychoactive Drugs, Analgesics and Evaluation in Penetrating Abdominal Trauma
This prospective observational study aims to evaluate whether alcohol consumption, psychoactive drug use, or prior administration of analgesics affects the clinical evaluation and surgical decision-making process in patients with…
- Conditions
- Abdominal Injuries, Alcohol Intoxication, Substance-related Disorders, Penetrating Abdominal Trauma
- Trial name
- DIRECT (NCT07330349)
- Testing
- Alcohol consumption, Psychoactive substance use, Analgesic administration
- Where
- 2 sites in Colombia
- Volunteers
- 363 people
- Sponsor
- Fundacion Clinica Valle del Lili
Anorexia Nervosa, Psychotropic Drugs
Drugs Experience for Adolescents With Anorexia
The purpose of this study is to access to the experiences of adolescents, their parents and healthcare professionals regarding psychotropic drugs in anorexia nervosa.
- Conditions
- Anorexia Nervosa, Psychotropic Drugs, Adolescent
- Trial name
- E3P (NCT06211517)
- Testing
- Semi-structured interviews with visual mediations, Semi-structured interviews
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mental Health Services
Pharmaceutical Care and Quality of Life in Conditions Related to Psychotropic Drug Use
This study aims to assess and describe the impact of pharmaceutical care on identified drug-related problems (DRPs) in subjects using psycholeptics and psychoanaleptics in primary care, improving subjects' self-assessed quality…
- Trial name
- NCT06889636
- Testing
- Pharmaceutical care in solving drug-related problems in subjects using psychotropic medicines based on standardized protocol.., Common pharmacists' practice in Croatia.
- Where
- Croatia
- Volunteers
- 97 people
- Sponsor
- University of Rijeka
Pregnant Women, Psychotropic Drugs
National Pregnancy Registry for Psychiatric Medications
The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications such as antidepressants, ADHD medications, sedative hypnotics, and atypical antipsychotics that many…
- Trial name
- NCT01246765
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Severe Poisoning With Cardiotropic or Psychotropic Drug, Admission to Intensive Care
Combined Gastrointestinal Decontamination in Acute Severe Poisoning
Gastrointestinal absorption of high dose medication (toxicant) ingested under solid form for suicidal purposes, is prolonged in patients who need intensive care admission and mechanical ventilation.
- Trial name
- DIMREATOX (NCT07201311)
- Testing
- Combination of activated charcoal with polyethylene glycol for digestive decontamination, Standard Treatment (Guideline-Based)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Phantom Limb Pain
Psilocybin-assisted Therapy for Phantom Limb Pain
This double-blind placebo-controlled pilot study seeks to investigate whether psilocybin can be safely administered to people with chronic phantom limb pain (PLP) in a supportive setting with close follow-up, and its effects on…
- Trial name
- NCT05224336
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Diego
Mental Disorder, Pharmacogenetics
Pharmacogenomics-Supported Psychotropic Prescribing Trial
Investigate the feasibility and utility of implementing pharmacogenetic testing for adults (aged 18 and older) seeking care for mental illness in Manitoba.
- Conditions
- Mental Disorder, Pharmacogenetics, Adverse Drug Reaction (ADR), Effectiveness
- Trial name
- PGx-SUPPORT (NCT06929533)
- Testing
- Pharmacogenetic Testing
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
PMS, PMDD
Microdosing LSD in Women With Premenstrual Disorders
The investigators aim to investigate the role of the serotonin 2A receptor in women with premenstrual disorders. This study uses a double-blind, randomized, controlled design with 3 arms: Intervention 1: 10 micg LSD for ~10 days…
- Trial name
- L4Her (NCT07189299)
- Testing
- LSD 10 μg every Day, LSD 10 μg every other day
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Friederike Holze
ADHD, Depression Disorders
Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device
The study aims to verify if the Gaize ocular device can effectively identify eye movements indicative of prescribed psychotropic medication usage by employing Drug Recognition Expert (DRE) testing protocols within a controlled…
- Conditions
- ADHD, Depression Disorders, Mood Disorders, Anxiety Disorder Generalized
- Trial name
- Rx Meds Gaize (NCT07389473)
- Testing
- Prescription Psychotropic Medications
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gaize
Anorexia Nervosa, Atypical Anorexia Nervosa
Ketamine Effects on Learning In Eating Disorders
This is a single site, single dose clinical trial of intravenous (IV) ketamine for medically hospitalized adolescents and young adults with anorexia nervosa or atypical anorexia nervosa.
- Trial name
- KETTLE (NCT06736769)
- Testing
- Ketamine infusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Amanda Downey, MD
Basic Science
LSD Occupancy of the Serotonin 2A Receptor in the Human Brain
The investigators wish to quantify the relation between administered dose of lysergic acid diethylamide (LSD), plasma LSD levels, and occupancy at the serotonin 2A receptor (5-HT2AR) using [11C]CIMBI-36 positron emission…
- Trial name
- dOccLS (NCT05953038)
- Testing
- Lysergic Acid Diethylamide Tartrate
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Wounds and Injuries, Out-of-Hospital Cardiac Arrest
Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac Arrest
This retrospective population-based cohort study uses linked administrative healthcare data from the Local Health Authority of Bologna (Italy) to describe the use of four classes of psychoactive drugs (opioids, antiepileptics…
- Conditions
- Wounds and Injuries, Out-of-Hospital Cardiac Arrest, Traumatic Brain Injury
- Trial name
- LIFT-C (NCT07882589)
- Testing
- Opioids (ATC N02A), Antiepileptics (ATC N03A), Antipsychotics (ATC N05A)
- Where
- 2 sites in Italy
- Volunteers
- 52,720 people
- Sponsor
- Azienda Usl di Bologna
Chronic Pain, Depression
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression.
- Trial name
- PEAK (NCT06317636)
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Health-Related Quality-of-Life, Social Capital
Cocreating Action to Improve Rationality in the Health System
Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination).
- Conditions
- Health-Related Quality-of-Life, Social Capital, Health Literacy, Community Based Participatory Research
- Trial name
- CAIR (NCT07237971)
- Testing
- Cocreation process
- Where
- 2 sites in Spain
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Deprescriptions, Antidepressive Agents
Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy
The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER…
- Conditions
- Deprescriptions, Antidepressive Agents, Antipsychotic Agents, Analgesics, Opioid
- Trial name
- PARTNER (NCT05842928)
- Testing
- PARTNER intervention, Control intervention
- Where
- 3 sites in Germany
- Volunteers
- 352 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Eating Disorders, Mood Disorders in Children and Adolescents
Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population
Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal.
- Conditions
- Eating Disorders, Mood Disorders in Children and Adolescents, Psychotic Disorder, QTc Intervals Changes
- Trial name
- NCT06870006
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS